Jung, Mankil - Yonsei University - Department of Chemistry

个人简介

International Journal (Nature) Award, 2005, Yonsei University. Outstanding Research Award, 2005, Yonsei University. Outstanding Research Award, 2002, Ministry of Health and Welfare. Whos's Who in the World (listed in 1999, Marquis Whos's Who).

研究领域

Asymmetric Synthesis of Biologically Active Natural Products. Drug Discovery and Development of Terpenes as Antiaging, Anticancer, Antimalarial and Antidiabetes. Nano material for Drug Delivery and Discovery Chemical Genomics/ Proteomics and Computer-Aided Drug Design. Microbial and Enzymatic Transformation and Biosynthesis of Natural Products.

近期论文

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Jung, M., et.al. "Daumone fed late in life improves survival and reduces hepatic inflammation and fibrosis in mice" Aging Cell, 2014, 13, 709. Jung, M., et.al. "Combined effects of an antioxidant and caspase inhibitor on the reversal of hepatic fibrosis in rats" Apoptosis, 2013, 18, 1481. Jung, M., et.al. "A simple synthesis of trans-3,4,5-trimethoxycinnamamides and evaluation of their biologic activity" Med. Chem. Res., 2013, 22, 4615 Jung, M., et.al. "First total synthesis of natural pulsatilla saponin D via highly stereospecific glycosylation" Tetrahedron, 2013, 69, 5481. Jung, M., et.al. "Synthesis and evaluation of a series of 3,4,5-trimethoxycinnamic acid derivatives as potential antinarcotic agents" Chem. Biol. Drug. Des., 2013, 81, 389. Jung, M., et.al. "Therapeutic effects of water soluble danshen extracts on antherosclerosis" Evid.-based Complement. Altern. Med., 2013, Article ID 623639. Jung, M., et.al. "Quantitative structure-activity relationship study of aromatic inhibitors against rat lens aldose-reductase activity using variable selections" Med. Chem., 2013, 9, 410. Jung, M., et.al. "Simple synthesis of modafinil derivatives and their antiinflammatory activity" Moleclues., 2012, 17, 10446. Jung, M., et.al. "Determination of daumone in mouse plasma by HPLC/MS-MS" Biomed. Chromatogr., 2012, 26, 152. Jung, M., et.al. "Total synthesis of flocoumafen via Knoevenagel Condensation and intramolecular ring cycclization: General access to natural products" Molecules., 2012, 17, 2091. Jung, M., et.al. "Convenient synthesis and biological evaluation of modafinil derivatives: benzhydrylsulfanyl and benzhydrylsulfinyl [1,2,3]triazol-4-yl-methyl esters" Molecules, 2011, 16, 10409. Jung, M., et.al. "Antifibrotic effects of magnesium lithospermate B on hepatic stellate cells and thioacetamide-induced cirrhotic rats" Exp. Mol. Med., 2011, 43, 341. Jung, M., et.al. "Synthesis of a Dual-Labeled Probe of Dimethyl Lithospermate B with Photochemical and Fluorescent Properties" Molecules, 2011, 16, 9886. Jung, M., et.al. "Discovery of artemisinin-glycolipid hybrids as anti-oral cancer agents" Chem. Pharm. Bull., 2011, 59, 1471. Jung, M., et.al. "Practical synthesis and biological evaluation of bergenin analogs" Chem. Biol. Drug. Des., 2011, 78, 725. Jung, M., et.al. "Quantitative determination of daumone in rat plasma by liquid chromatography-mass spectrometry" J. Pharm. Biomed. Anal., 2011, 56, 114. Jung, M., et.al. "Concise synthesis and antiangiogenic activity of artemisinin–glycolipid hybrids on chorioallantoic membranes" Bioorg. Med. Chem. Lett., 2010, 20, 6858. Jung, M., et.al. "Natural therapeutic magnesium lithospermate potently protects the endothelium from hyperglycaemia-induced dysfunction" Cadiovasc. Res., 2010, 87, 713. Jung, M., et.al. "Protective effects of magnesium lithospermate B against diabetic atherosclerosis via Nrf2-ARE-NQ01 transcriptional pathway" Atheroscleosis, 2010, 211, 69. Jung, M., et.al. "Design, synthesis, and biological evaluation of 3,4,5-trimethoxyphenyl acrylamides as antinargotic agents." J. Enzym. Inhib. Med. Chem., 2010, 25, 38. Jung, M., et.al. "Synthesis and anticancer activity of novel amide derivatives of non-acetal deoxoartemisinin." Bioorg. Med. Chem. Lett., 2009, 19, 6303. Jung, M., et.al. "Photophysics of a new photosensitizer with high quantum yield of singlet oxygen generation and its application to stereo-selective synthesis of (+)-deoxoartemisinin." Chem. Phys. Lett., 2009, 482, 81.