个人简介

PH.D. CHEMISTRY, 2007 UNIVERSITY OF WISCONSIN-MADISON, MADISON, WI B.S.–M.S. CHEMISTRY, 2001-2002 WRIGHT STATE UNIVERSITY, DAYTON, OH Brian was born and raised in Dayton, OH. He received B.S. and M.S. degrees in Chemistry from Wright State University in 2001 and 2002. During this time, he worked in the lab of Prof. Vladimir Katovic studying the electrochemical properties of transition-metal complexes in room-temperature ionic liquids. He continued his graduate work at the University of Wisconsin-Madison under the mentorship of Prof. Shannon Stahl in the area of mechanistic inorganic/organometallic chemistry. He received a Ph.D. in Inorganic Chemistry in 2007 for his work unraveling the details of the oxygenation of reduced-Pd species relevant to homogeneous aerobic oxidation catalysis. In 2008, he moved to Rice University in Houston, Texas as a J. Evans Attwell-Welch Postdoctoral Fellow in the laboratory of Prof. Zach Ball where he gained a new perspective on organometallic catalysis by developing enzyme-like approaches for site-selective peptide and protein modification for the chemical biology community. He has been a been a tenure-track assistant professor in the C. Eugene Bennett Department of Chemistry in the Eberly College of Arts and Sciences since August 2011. His research group interests mainly center in the areas of synthetic and mechanistic organometallic chemistry where he also employs computational techniques to complement the experimental studies. The group is also broadly interested in developing and employing contemporary chemical techniques for biological problems. AWARDS: •Brodie Discovery and Innovation Award 2012 •J. Evans Attwell-Welch Postdoctoral Research Fellowship 2008 •Inorganic Chemistry Graduate Student Excellence in Research Award 2007 •Perkin Medal Scholarship presented by Dr. Jim Stevens (Corporate Fellow, Dow Chemical) 2006 •Belle-Crowe Excellence in Inorganic Chemistry Award 2002 •Dubois-Nussey Excellence in Chemistry Scholarship 2000

研究领域

Organic, Bioorganic & Medicinal Chemistry

The Popp research group is broadly interested in synthetic and biological transition-metal-catalyzed reactions. We have specific interests in exploiting ligand architectures, featuring rationally designed secondary-sphere interactions, that will influence the primary coordination environment of a reactive transition-metal center. Nature routinely uses non-covalent interactions and multiple metal centers in enzyme active sites to influence the rate and control the selectivity of catalytic reactions. Thus mimicking aspects of enzymatic catalysis is expected to reveal new directions for tackling challenging problems in synthetic and applied areas of catalysis research. We are targeting three general ligand frameworks that feature different enzyme-like elements. In peptides and proteins, oxidative cross-linking of tyrosine’s phenolic side chains produces the dityrosine moiety, which is being explored as a modular ligand platform for applications in asymmetric catalysis and chemical biology. Zwitterionic phosphino-borate-ligated and heterobimetallic metal complexes are being explored for a variety of small-molecule activation chemistries important in green chemistry and sustainability efforts. The group’s research philosophy is predicated on concurrent methodology–mechanism lines of inquiry. The developing researcher can expect to gain substantial exposure to techniques promoting both facets of the research program. A few specific areas include reaction screening and parallelization, handling environmentally sensitive materials, synthesis and characterization of biopolymers (peptides and proteins), kinetics of catalytic reactions, and computational modeling.

近期论文

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“Sequence-Specific Inhibition of a Designed Metallopeptide Catalyst” Popp, B. V.; Chen, Z.; Ball, Z. T. Chem. Commun. 2012, 48, 7492-7494. “Hybrid Organic-Inorganic Inhibitors of a PDZ Interaction that Regulates the Endocytic Fate of CFTR” Kundu, R.; Cushing, P. R.; Popp, B. V.; Zhao, Y.; Madden, D. R.; Ball, Z. T. Angew. Chem. Int. Ed. 2012, 51, 7217-7220. “Reaction of O2 with [(–)-Sparteine]Pd(H)Cl: Evidence for an Intramolecular [H-L]+ “Reductive Elimination” Pathway” Decharin, N.; Popp, B. V.; Stahl, S. S. J. Am. Chem. Soc. 2011, 133, 13268-13271. “Site-Specific Protein Modification with a Dirhodium-Metallopeptide Catalyst” Chen, Z; Popp, B. V.; Bovet, C. L.; Ball, Z. T. ACS Chem. Bio. 2011, 6, 920-925. “Mechanistic Studies of Wacker-type Intramolecular Oxidative Amination of Alkenes Catalyzed by Pd(OAc)2/Pyridine” Ye, X.; Liu, G.; Popp, B. V.; Stahl, S. S. J. Org. Chem. 2011, 76, 1031-1044. “Proximity-Driven Metallopeptide Catalysis: Remarkable Side-Chain Scope Enables Modification of the Fos bZip Domain” Popp, B. V.; Ball, Z. T. Chem Sci. 2011, 2, 690-695. “O2 Insertion into a Palladium-Hydride Bond: Observation of Mechanistic Crossover between HX-Reductive-Elimination and Hydrogen-Atom-Abstraction Pathways” Konnick, M. M.; Decharin, N. D.; Popp, B. V.; Stahl, S. S. Chem. Sci. 2011, 2, 326-330. “Electronic Structural Comparison of the Reactions of Dioxygen and Electron-Deficient Alkenes with Nitrogen-Chelated Palladium(0)” Popp, B. V.; Morales, C. M.; Landis, C. R.; Stahl, S. S. Inorg. Chem. 2010, 49, 8200-8207. “Helix Induction by Dirhodium: Access to Biocompatible Metallopeptides with Defined Secondary Structure” Zaykov. A.; Popp, B. V.; Ball, Z. T. Chem. Eur. J. 2010, 16, 6651-6659. “Structure-Selective Modification of Aromatic Side Chains with Dirhodium Metallopeptide Catalysts” Popp, B. V.; Ball, Z. T. J. Am. Chem. Soc. 2010, 132, 6660-6662. “Mechanism of Pd(OAc)2/Pyrdine Catalyst Reoxidation by O2: Influence of Labile Monodentate Ligands and Identification of a Biomimetic Mechanism for O2 Activation” Popp, B. V.; Stahl, S. S. Chem. Eur. J. 2009, 15, 2915-2922. “Insertion of Molecular Oxygen into a Pd-Hydride Bond: Computational Evidence for Two Nearly Isoenergetic Pathways” Popp, B. V.; Stahl, S. S. J. Am. Chem. Soc. 2007, 129, 4410-4422. “Reaction of Molecular Oxygen with an NHC-Coordinated Pd0 Complex: Computational Insights and Experimental Implications” Popp, B. V.; Wendlandt, J. E.; Landis, C. R.; Stahl, S. S. Angew. Chem. Int. Ed. 2007, 46, 601-604. “Palladium-Catalyzed Oxidation Reactions: Comparison of Benzoquinone and Molecular Oxygen as Stoichiometric Oxidants” Popp, B. V.; Stahl, S. S. Top. Organomet. Chem. 2007, 22, 149-189. “Similarities Between the Reactions of Dioxygen and Alkenes with Palladium(0): Relevance to the Use of Benzoquinone and Molecular Oxygen as Stoichiometric Oxidants in Palladium-Catalyzed Oxidation Reactions” Popp, B. V.; Thorman, J. L.; Stahl, S. S. J. Mol. Cat. A: Chem. 2006, 251, 2-7. “"Oxidatively-Induced" Reductive Elimination of Dioxygen from an η2-Peroxopalladium(II) Complex Promoted by Electron-Deficient Alkenes” Popp, B. V.; Stahl, S. S. J. Am. Chem. Soc. 2006, 128, 2804-2805. “Development of 7-Membered N-Heterocyclic Carbene Ligands for Transition Metals” Scarborough, C. C.; Popp, B. V.; Guzei, I. A.; Stahl, S. S. J. Organomet. Chem. 2005, 690, 6143-6155. “"Inverse-electron-demand" Ligand Substitution: Experimental and Computational Insights into Olefin Exchange at Palladium(0)” Popp, B. V.; Thorman, J. L.; Morales, C. M.; Landis, C. R.; Stahl, S. S. J. Am. Chem. Soc. 2004, 126, 14832-14842.