个人简介

Ph.D. University of North Carolina

研究领域

Analytical Chemistry;Nanoscience

Research in my lab centers on the use of capillary column liquid chromatography and capillary electrophoresis, to study physiological processes [1-3]. These miniaturized separation techniques provide lower solvent consumption, tunable method parameters, systems capable of resolving individual components of complex mixtures and may be translated into devices and methodology which are more portable and affordable. These characteristics make cLC and CE excellent tools for an integrated approach for the investigation of affinity interaction, rapid screening protocol for drug research or environmental monitoring, and the development of new tools to understand the basis of disease. For more information, see the web links to research projects.

近期论文

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X. Wu, TJ Langan, B.C. Durney, L.A. Holland, “Thermally Responsive Phospholipid Preparations for Fluid Steering and Separation in Microfluidics”, Electrophoresis 2012, 37, 2674-81. TJ Langan, L.A. Holland, “Capillary electrophoresis coupled to electrospray mass spectrometry through a coaxial sheath flow interface and semi-permanent phospholipid coating for the determination of oligosaccharides labeled with 1-aminopyrene-3,6,8-trisulfonic acid”, Electrophoresis 2012, 33, 607-613. T.J. Langan, V.T. Nyakubaya, L.D. Casto, T.D. Dolan S.A. Archer-Hartmann, S.L. Yedlapalli, L.J. Sooter, L.A. Holland, “Assessment of Aptamer-Steroid Binding Using Stacking Enhanced Capillary Electrophoresis” Electrophoresis 2012, 33, 866-869. S.A. Archer-Hartmann, C.L. Crihfield, L.A. Holland, “On-Line Enzymatic Sequencing of Glycans from Trastuzumab by Phospholipid Assisted Capillary Electrophoresis” Electrophoresis 2011, 32, 3491-3498. S.A. Archer-Hartmann, L.A. Holland, “Self-Assembled Nanomaterials for Enhanced Chemical Separations” LC-GC North America 2011, 29(5), 384-393. S.A. Archer-Hartmann, L.M. Sargent, D. Lowry, L.A. Holland, “Microscale Exoglycosidase Processing and Lectin Capture of Glycans with Phospholipid Assisted Capillary Electrophoresis Separations” Analytical Chemistry 2011, 83(7), 2740-2047. L.A. Holland “Capillary Electrophoresis: Focus on Undergraduate Laboratory” Journal of Chemical Education 2011, 88(3), 254-256. C.M. White, L.A. Holland, P Famouri, “Application of Capillary Electrophoresis to Predict Crossover Frequency of Polystyrene Particles in Dielectrophoresis”, Electrophoresis 2010, 31(15), 2664-2671. L. Bykova, S.A. Archer-Hartmann, L.A. Holland, L. Iwanowicz, V.S. Blazer, “Steroid Determination in Fish Plasma Using Capillary Electrophoresis”, Environmental Toxicology and Chemistry 2010, 29(9), 1950-1955. R. Luo, S.A. Archer-Hartmann, L.A. Holland, “Transformable Capillary Electrophoresis for Oligosaccharides Separation Using Phospholipid Additives”, Analytical Chemistry 2010, 82, 1228-1233.