Jones, Amanda - Wake Forest University - Department of Chemistry

个人简介

A.B., 2001, Princeton University (Prof. Maitland Jones, Jr.) Ph.D., 2007, University of Wisconsin-Madison (Prof. Hans J. Reich) NIH Post-doctoral Fellow, 2007-2010, California Institute of Technology (Prof. Brian M. Stoltz),

研究领域

Homogeneous gold(I) catalysts have emerged as powerful reagents for activating unsaturated hydrocarbons (pi-systems) toward nucleophilic addition and involvement in selective skeletal rearrangements. The products of these reactions are important building blocks in syntheses of pharmaceuticals and materials; however, the mechanisms of these processes are not fully understood. Our work is focused on the examination of the structure, formation, and reactivity of gold complexes. This includes a detailed exploration of ligand effects on the kinetics and stability of reactive intermediates relevant to catalysis. The information we obtain will be used to improve the scope, catalytic efficiency, and cost-effectiveness of gold(I) catalysts, thus expanding chemists synthetic capabilities.

近期论文

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Sriram, M.; Zhu, Y.; Camp, A. M.; Day, C. S.; Jones, A. C. Structure and Dynamic Behavior of Phosphine Gold(I)-Coordinated Enamines: Characterization of α-Metalated Iminium Ions. Organometallics, 2014, 33, 4157–4164. Invited to be highlighted with a Cover Illustration!TOC-Cover-Image Zhu, Y.; Day, C. S.; Zhang, L.; Hauser, K.; Jones, A. C. A Unique Au-Ag-Au Triangular Motif in a Trimetallic Halonium Dication: Silver Incorporation in a Gold(I) Catalyst. Chem. Eur. J. 2013, 19, 12264–12271. Invited to be highlighted with a Frontispiece Image. Zhu, Y.; Day, Cynthia S.; Jones, A. C. Synthesis and Structure of Cationic Phosphine Gold (I) Enol Ether Complexes. Organometallics 2012, 31, 7332–7335. Jones, A. C.; May, J. A., Sarpong, R.; Stoltz, B. M. To a Symphony of Reactivity. Cascades Involving Catalysis and Sigmatropic Rearrangements. Angew. Chem. Int. Ed. 2013, 53, 2556-2591. Craig, R. A. II; Roizen, J. L; Smith, R. C.; Jones, A. C.; Stoltz, B. M. Enantioselective Synthesis of a Hydroxymethyl-cis-1,3-cyclopentenediol Building Block. Org. Lett. 2012, 14, 5716–5719. Chou, T.; Brown, S. J.; Minond, D.; Nordin, B. E.; Li, K.; Jones, A. C.; Chase, P.; Porubsky, P. R.; Stoltz, B. M.; Schoenen, F. J.; Patricelli, M. P.; Hodder, P.; Rosen, H.; Deshaies, R. J. Reversible inhibitor of p97, DBeQ, impairs both ubiquitin-dependent and autophagic protein clearance pathways. Proc. Natl. Acad. Sci. U. S. A. 2011, 108, 4834–4839. Reich, H. J.; Sikorski, W. H.; Sanders, A. W.; Jones, A. C.; Plessel, K. N. Multinuclear NMR Study of the Solution Structure and Reactivity of Tris(trimethylsilyl)methyllithium and its Iodine Ate Complex. J. Org. Chem. 2009, 74, 719–729. Jones, A. C.; Sanders, A. W.; Sikorski, W. H.; Jansen, K. L.; Reich, H. J. Reactivity of the Triple Ion and Separated Ion Pair of Tris(trimethylsilyl)methyllithium with Aldehydes: A RINMR Study. J. Am. Chem. Soc. 2008, 130, 6060–6061. Jones, A. C.; Sanders, A. W.; Bevan, M. J., Reich, H. J. Reactivity of Individual Organolithium Aggregates – a RINMR Study of n-Butyllithium and 2-Methoxy-6-(methoxymethyl)phenyllithium. J. Am. Chem. Soc. 2007, 129, 3492–3493. Reich, H. J.; Sikorski, W. H.; Thompson, J. L.; Sanders, A. W.; Jones, A. C. Interconversion of Contact and Separated Ion Pairs in Silyl- and Arylthio-Substituted Alkyllithium Reagents. Org. Lett. 2006, 8, 4003–4006. Bradley, A. Z.; Cohen, A. D.; Jones, A. C.; Ho, D. M.; Jones, M., Jr. Photolysis of Naphthocarborane and Benzocarborane in Oxygen. Tetrahedron Lett. 2000, 41, 8695–8698.