Haines, Julie - Wake Forest University - Department of Chemistry

个人简介

B.S. in Chemistry, Allegheny College, 2007 Ph.D. in Chemistry, Wake Forest University, December 2011 Postdoctoral Research in Molecular Medicine, Wake Forest School of Medicine, 2012-2014

研究领域

My efforts are focused on developing methods and facilitating research efforts using mass spectrometry (MS). Mass spectrometers provide a powerful means for analyzing molecules and their behavior, from small atmospheric gases to large biomolecules like proteins. From MS data we obtain important structural information helping to identify characteristics like organic functional groups and the primary sequence of peptides and proteins. More sophisticated methods allow for the relative quantification of molecules across samples, forming the basis for proteomics and metabolomics analyses.

近期论文

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Miao Z; Reisz JA; Mitroka SM; Pan J; Xian M; King SB. A selective phosphine-based fluorescent probe for nitroxyl in living cells. Bioorg Med Chem Lett. 2014, 25, 16. Devarie Baez NO*; Reisz JA*; Furdui CM. Mass spectrometry in the analysis of protein thiol chemistry and signaling: Opportunities and caveats. Free Radic Biol Med, 2014 Sept 28, epub ahead of print; PMID 25261734. [*equal authorship] Poole TH*; Reisz JA*; Zhao W; Poole LB; Furdui CM; King SB. Strained cycloalkynes as new protein sulfenic acid traps. J Am Chem Soc. 2014, 136, 6167. [*equal authorship] Reisz JA; Bansal N; Qian J; Zhao W; Furdui CM. Effects of ionizing radiation on biological molecules – mechanisms of damage and emerging methods of detection. Antioxid Redox Signal. 2014, 21, 260. Reisz JA; Bechtold E; King SB; Poole LB; Furdui CM. Thiol-blocking electrophiles interfere with labeling and detection of protein sulfenic acids. FEBS J. 2013, 280, 6150. Haynes A; Qian J; Reisz JA; Furdui CM; Lowther TL. Molecular basis for the resistance of human mitochondrial 2-Cys peroxiredoxin 3 to hyperoxidation. J Biol Chem. 2013, 288, 29714. Huang Z; Kaur J; Bhardwaj A; Alsalah N; Reisz JA; DuMond JF; King SB; Seubert JM; Zhang Y; Knaus EE. O2-Sulfonylethyl protected isopropylamine diazen-1-ium-1,2-diolates as nitroxyl (HNO) donors: Synthesis, b-elimination fragmentation, HNO release, positive inotropic properties, and blood pressure lowering studies. J Med Chem. 2012, 55, 10262. Reisz JA; Zink CN; King SB. Rapid and selective nitroxyl (HNO) trapping by phosphines: Kinetics and new aqueous ligations for HNO detection and quantitation. J Am Chem Soc. 2011, 133, 11675. Huang Z; Velázquez CA; Abdellatif KRA; Chowdhury MA; Reisz JA; DuMond JF; King SB; Knaus EE. Ethanesulfohydroxamic acid ester prodrugs of non-steroidal anti-inflammatory drugs (NSAIDs): Synthesis, nitric oxide and nitroxyl release, cyclooxygenase inhibition, anti-inflammatory and ulcerogenicity index studies. J Med Chem. 2011, 54, 1356. Reisz JA; Bechtold E; King SB. Oxidative heme protein-mediated nitroxyl (HNO) generation. Dalton Transactions. 2010, 39, 5203. Bechtold E; Reisz JA; Klomsiri C; Tsang AW; Wright MW; Poole LB; Furdui CM; King SB. Water-soluble triarylphosphines as biomarkers for protein S-nitrosation. ACS Chem Biol. 2010, 5, 405. Huang Z; Velazquez C; Abdellatif K; Chowdhury M; Jain S; Reisz J; DuMond J; King SB; Knaus E. Acyclic triaryl olefins possessing a sulfohydroxamic acid pharmacophore: Synthesis, nitric oxide/nitroxyl release, cyclooxygenase inhibition, and anti-inflammatory studies. Org Biomol Chem. 2010, 8, 4124. Reisz JA; Klorig EB; Wright MW; King SB. Reductive phosphine-mediated ligation of nitroxyl (HNO). Org Lett. 2009, 11, 2719.