Alexander, Rebecca - Wake Forest University

个人简介

B.S., University of Delaware, 1990, Honors PhD, University of Pennsylvania, 1996, (Barry S. Cooperman) Postdoctoral Research Associate 1996-1997, MIT, (Paul Schimmel) Postdoctoral Research Associate 1997-1999, The Scripps Research Institute, (Paul Schimmel)

研究领域

Our research program is primarily centered on understanding the mechanisms of protein synthesis. Translation of a single protein from its nucleic acid precursor requires dozens of cellular components. Amino acids are assembled into polypeptides at the ribosome, a large ribonucleoprotein complex where the genetic message is decoded. Individual proteins play essential roles in maintaining the accuracy of translation. The aminoacyl-tRNA synthetases attach amino acids to transfer RNA (tRNA) molecules, thereby establishing the genetic code that dictates which amino acid matches which trinucleotide codon. Other protein factors facilitate the three steps of translation: initiation, elongation, and termination.

近期论文

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Budiman, M.E., Knaggs, M.H., Fetrow, J.S., and Alexander, R.W. "Using molecular dynamics simulations to probe interaction networks in an aminoacyl-tRNA synthetase." Proteins 2007, 68: 670-689. Turner, A.W., Love, C., Alexander, R.W., and Jones, P.G. "Mutational analysis of E. coli DEAD-box protein CsdA." J. Bacteriology 2007, 189: 2769-2776. Budiman, M.E., Bierbach, U., and Alexander, R.W. “DNA minor groove adducts formed by a platinum-acridine conjugate inhibit association of TATA-binding protein with its cognate sequence.” Biochemistry 2005, 44: 11262-11268. Budiman, M.E., Alexander, R.W., and Bierbach, U. “Unique base-step recognition by a platinum-acridinylthiourea conjugate leads to a DNA damage profile complementary to that of the anticancer drug cisplatin.” Biochemistry 2004, 43: 8560-8567. Alexander, R.W., and Tamura, K. “Peptide synthesis through evolution.” Cell. Mol. Life Sci. 2004, 61: 1317-1330. Alexander, R.W., and Schimmel, P. “Domain-domain communication in aminoacyl-tRNA synthetases.” Prog. Nucl. Acid Res. Mol. Biol. 2001, 69: 317-349. Alexander, R.W., and Schimmel, P. “Evidence for breaking domain-domain functional communication in a synthetase-tRNA complex.” Biochemistry 1999, 38: 16359-16365. Wang, R., Alexander, R.W., van Loock, M., Vladimirov, S., Bukhtiyarov, Y., Harvey, S.C., and Cooperman, B.S. “Three-dimensional placement of the conserved 530 loop of 16 S rRNA and of its neighboring components in the 30 S subunit.” J. Mol. Biol. 1999 , 286: 521-540. Alexander, R.W., Nordin, B.E., and Schimmel, P. “Activation of microhelix charging by localized helix destabilization.” Proc. Natl. Acad. Sci. USA 1998, 95: 12214-12219. Alexander, R.W., and Cooperman, B.S. “Ribosomal proteins neighboring 23 S rRNA nucleotides 803-811 within the 50 S subunit.” Biochemistry 1998 , 37: 1714-1721. Muralikrishna, P., Alexander, R.W., and Cooperman, B.S. (1997) “Placement of the a- sarcin loop within the 50 S subunit: Evidence derived using a photolabile oligodeoxynucleotide probe.” Nucleic Acids Res. 1997 , 25: 4562-4569. Alexander, R.W., Muralikrishna, P., and Cooperman, B.S. “Ribosomal components neighboring the conserved 518-533 loop of 16S rRNA in 30S subunits.” Biochemistry 1994, 33: 12109-12118. Rosen, K.V., Alexander, R.W., Wower, J., and Zimmermann, R.A. “Mapping the central fold of transfer RNA 2 fMet in the P-site of the Escherichia coli ribosome.” Biochemistry 1993, 32: 12802-12811. Alexander, R.W. “Measure for measure: a zinc finger ruler.” Trends Biochem. Sci. 2002 , 27: 390. Alexander, R.W. “Not so picky: a permissive thioesterase domain cyclizes novel integrin binders.” Trends Biochem. Sci. 2002 , 27: 119-120. Alexander, R.W., and Schimmel, P. “Protein synthesis” In Encyclopedia of Physical Science and Technology (Robert A. Myers, ed.) 3 rd ed., Vol. 13. 2002, Academic Press ( San Diego, CA), 219-240. Alexander, R.W., and Schimmel, P. “Suppression” In Encyclopedia of Genetics (S. Brenner and J. Miller, Eds), 2001, Academic Press, London, 1897-1899. Alexander, R.W., and Schimmel, P. “Wobble hypothesis” In Encyclopedia of Genetics (S. Brenner and J. Miller, Eds.), 2001, Academic Press, London, 2140-2141. Alexander, R.W. “Choking on a knot: insecticidal properties of cyclotides.” Trends Biochem. Sci. 2001 , 26: 588. Alexander, R.W. “Peptides with zip: small molecules for structure prediction.” Trends Biochem. Sci. 2001 , 26: 352.