Wong, Chi-Huey - The Scripps Research Institute

研究领域

Research in the Wong lab encompasses a broad spectrum of bioorganic and synthetic chemistry. Development of small molecules targeting RNA and design and synthesis of inhibitors to enzymes and receptors are being performed to investigate how small molecules interact with biologically important molecules and in turn, learn more about the function of those molecules. Development of both synthetic and bioorganic strategies is also paramount to our research. Programmable one-pot reactions can be used for the synthesis of complex oligosaccharides and glycoarrays, and complement development of new enzymatic catalysts for glycoprotein synthesis and other organic reactions.

近期论文

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H.-Y. Lee, C.-Y. Chen, T.-I. Tsai, S.-T. Li, K.-H. Lin, Y.-Y. Cheng, C.-T. Ren, T.-J. Cheng, C.-Y. Wu, C.-H. Wong, “Immunogenicity study of Globo H derivatives with modification at the reducing or non-reducing end of the tumor antigen,” Journal of the American Chemical Society, 2014, in press. B.-T. Hong, C.-L. Chen, Jim-Min Fang, Shi-Yun Wang, Wen-I Huang, Yih-Shyun E. Cheng, Chi-Huey Wong, “Oseltamivir Hydroxamate and Acyl Sulfonamide Derivatives as Influenza Neuraminidase Inhibitors,” Bioorganic and Medicinal Chemistry, 2014, in press. J.-T. Hung, Y.-C. Tsai, W.-D. Lin, J.-T. Jan, K.-H. Lin, J.-R. Huang, J.-Y. Cheng, M.-W. Chen, C.-H. Wong, and A. L. Yu, “Potent adjuvant effects of novel NKT stimulatory glycolipids on hemagglutinin based DNA vaccine for H5N1 influenza virus,” Antiviral Research, 2014,107:110-118. C.-H. Hsu, M. Schelwies, S. Enck, L.-Y. Huang, S.-H. Huang, Y.-F. Chang, T.-J. Cheng, W.-C. Cheng, C.-H. Wong, “Iminosugar C-Glycoside Analogues of alpha-D-GlcNAc-1-Phosphate: Synthesis and Bacterial Transglycosylase Inhibition,” Journal of Organic Chemistry, 2014,79(18):8629-8637. C.-Y. Wang, C.-Y. Wu, T.-J. Hung, C.-H. Wong, C.-H. Chen, “Sequence-constructive SELEX: A new strategy for screening DNA aptamer binding to Globo H,” Biochemical and Biophysical Research Communications, 2014, S0006-291X(14)01509-01515. L.-Y. Huang, S.-H. Huang, Y.-C. Chang, W.-C. Cheng, T.-J. R. Cheng, and C.-H. Wong, “Enzymatic synthesis of Lipid II and analogues,” Angewandte Chemie, International Edition, 2014, 53(31): 8060-8065. C.-L. Chen, T.-C. Lin, S.-Y. Wang, J.-J. Shie, K.-C. Tsai, Y.-S. E. Cheng, J.-T. Jan, C.-J. Lin, J.-M. Fang, C.-H. Wong, “Tamiphosphor Monoesters as Effective Anti-influenza Agents,” European Journal of Medicinal Chemistry, 2014, 81:106-118. Y.-Y. Tseng, J.-M. Liou, T.-L. Hsu, W.-C. Cheng, M.-S. Wu, C.-H. Wong, “Development of bacterial transglycosylase inhibitors as new antibiotics: Moenomycin A treatment for drug-resistant Helicobacter pylori,” Bioorganic and Medicinal Chemistry Letters, 2014, 24(11):2412-2414. E. Falkowska, A. Ramos, K. J. Doores, J. H. Lee, C. Blattner, A. Ramirez, R. Derking, M. J. van Gils, C.-H. Liang, R. Mcbride, S. S. Shivatare, C.-Y. Wu, P.-Y. Chan-Hui, Y. Liu, T. Feizi, M. B. Zwick, W. C. Koff, M. S. Seaman, K. Swiderek, J. P. Moore, J. C. Paulson, C.-H. Wong, A. B. Ward, I. A. Wilson, R. W. Sanders, P. Poignard, D. R. Burton, “Broadly neutralizing HIV antibodies define a novel glycan-dependent epitope on the pre-fusion conformation of gp41 on cleaved Envelope trimmers,” Immunity, 2014, 40(5):657-68. P.-C. Chen, P.-K. Chuang, C.-H. Chen, J.-R. Chen, S.-W. Lin, C. Ma, T.-L. Hsu, C.-H. Wong, “Role of N-Linked Glycans in the Interactions of the HCV Envelope Glycoproteins with Cellular Receptors,” ACS Chemical Biology, 2014, 9(7):1437-43. J.-J. Shie, Y.-C. Liu, Y.-M. Lee, C. Lim, J.-M. Fang, C.-H. Wong, “An Azido-BODIPY Probe for Glycosylation: Initiation of Strong Fluorescence Upon Triazole Formation,” Journal of the American Chemical Society, 2014, 136(28): 9953-61. S.-C. Lin, W.-C. Liu, J.-T. Jan, C.-H. Wong, S.-C. Wu, “Glycan Masking of Hemagglutinin for Adenovirus Vector and Recombinant Protein Immunizations Elicits Broadly Neutralizing Antibodies against H5N1 Avian Influenza Viruses,” PLOS ONE, 2014, 9(3): e92822. J. Lin, Y.-J. Chang, W.-B. Yang, A. L. Yu, and C.-H. Wong, “The multifaceted effects of Dendrobium huoshanense on immune functions with the induction of Interleukin-1 receptor antagonist (IL-1ra) in monocytes," PLOS ONE, 2014, 9(4):e94040. A.-K. Sauer, C.-H. Liang, J. Stech, B. Peeters, P. Quere, C. Schwegmann-Wessels, C.-Y. Wu, C.-H. Wong, G. Herrler, “Characterization of the sialic acid binding activity of influenza A viruses using soluble variants of the H7 and H9 hemagglutinin subtypes as lectins,” PLOS ONE, 2014, 9(2):e89529. J -R. Huang , Y.-C. Tsia , Y.-J. Chang , J.-C. Wu , J.-T. Hung , K.-H. Lin , C.-H. Wong and Alice L. Yu, “a-GalCer but not phenyl-glycolipipds induced NKT cell anergy and IL-33 mediated MDSC accumulation via upregulation of egr2/3,” Journal of Immunology, 2014, 192(4):1972-81. Y.-W. Lou, P.-Y. Wang, S.-C. Yeh, P.-K. Chuang, S.-T. Li, C.-Y. Wu, K.-H. Khoo, M. Hsiao, T.-L. Hsu, C.-H. Wong, “SSEA-4 as a Potential Therapeutic Target in Glioblastoma Multiforme and Other Cancers,” Proceedings of the National Academy of Sciences of the United States of America, 2014, 111(7):2482-7. J.-R. Chen, Y.-H. Yu, Y.-C. Tseng, W.-L. Chiang, M.-F. Chiang, Y.-A. Ko, Y.-K. Chiu, S.-H. Ma, C.-Y. Wu, J.-T. Jan, K.-I. Lin, C. Ma, C.-H. Wong, “Vaccination of Monoglycosylated Hemagglutinin Induces Cross-Strain Protection against Influenza Virus Infections,” Proceedings of the National Academy of Sciences of the United States of America, 2014, 111(7):2476-81. C.-S. Chu, P.-W. Lo, Y.-H. Yeh, P.-H. Hsu, S.-H. Peng, Y.-C. Teng, M.-L. Kang, C.-H. Wong, L.-J. Juan, “O-GlcNAcylation regulates EZH2 protein stability and function,” Proceedings of the National Academy of Sciences of the United States of America, 2014, 111(4):1355-60. Y.-S. Chen, H.-M. Yu, J.-J. Shie, T.-J. R. Cheng, C.-Y. Wu, J.-M. Fang, C.-H. Wong, “Chemical constituents of Plectranthus amboinicus and the synthetic analogs possessing anti-inflammatory activity,” Bioorganic and Medicinal Chemistry, 2014, 22(5):1766-72. T.-L. Hsu, G. Lin, A. Koizumi, K. Brehm, N. Hada, P.-K.Chuang, C.-H. Wong, S.-L. Hsieh, A. Diaz, “The surface carbohydrates of the Echinococcus granulosus larva interact selectively with the rodent Kupffer cell receptor,” Molecular & Biochemical Parasitology, 2013, 192(1-2):55-9.