Snyder, Scott - The Scripps Research Institute

个人简介

Education 2004 – 2006 NIH Postdoctoral Associate Advisor: Professor E. J. Corey Harvard University, Cambridge, MA 1999 – 2004 NSF, Pfizer, and Bristol-Myers Squibb Doctoral Fellow in Chemistry Advisor: Professor K. C. Nicolaou The Scripps Research Institute, La Jolla, CA 1995 – 1999 B. A. with highest honors in Chemistry, Summa Cum Laude, valedictorian Advisor: Professor J. Hodge Markgraf Williams College, Williamstown, MA

研究领域

For synthetic organic chemistry to reach its full potential as an enabling science, especially in terms of its impact on biomedical research, we must develop the skills not only to prepare any molecule efficiently, on-scale, and in environmentally benign ways, but also to tailor it in any way imaginable so that we can confer upon it whatever new properties we might desire. Meeting this lofty objective requires complete command over chemoselectivity: the ability to differentiate and controllably functionalize any site within a given molecule. Our research program uses the inspiration of Nature’s chemoselective syntheses of tens of thousands of natural products through highly controlled cyclization and functionalization chemistries to provide a sense of our ultimate goal and to identify critical challenges worthy of laboratory execution. Efforts to date have focused on oligomeric polyphenols, halogenated natural products, stereochemically-dense terpenes, and polycyclic alkaloids, and have afforded several new reagents, strategies, and tactics of broad applicability.

近期论文

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T. C. Sherwood, A. H. Trotta, S. A. Snyder. A Strategy for Complex Dimer Formation When Biomimicry Fails: Synthesis of 10 Coccinellid Alkaloids. J. Am. Chem. Soc. 2014, 136, 9743. • Covered in Chemistry World magazine N. E. Wright, A. M. ElSohly, S. A. Snyder. Syntheses of Cyclotriveratrylene Analogues and Their Long Elusive Triketone Congeners. Org. Lett. 2014, 16, 3644. T. H. Jepsen, S. B. Thomas, Y. Lin, C. I. Stathakis, I. de Miguel, S. A. Snyder. Harnessing Quinone Methides: Total Synthesis of (+)-Vaticanol A. Angew. Chem. Int. Ed. 2014, 53, 6747. • Selected by the editors as a Hot Paper • Featured in Synfacts 2014, 784. N. E. Wright, S. A. Snyder. 9-Membered Carbocycle Formation: Development of Distinct Friedel–Crafts Cyclizations and Application to a Scalable Total Synthesis of (+)-Caraphenol A. Angew. Chem. Int. Ed. 2014, 53, 3409. • Featured in Synfacts 2014, 448. D. R. Griffith, L. Botta, T. G. St. Denis, S. A. Snyder. Explorations of Unique Caffeic Acid Derivatives: Total Syntheses of Rufescenolide, Yunnaneic Acids C and D, and Studies toward Yunnaneic Acids A and B. J. Org. Chem. 2014, 79, 88. M. W. Smith, S. A. Snyder. A Concise Synthesis of (+)-Scholarisine A Empowered by a Unique C-H Arylation. J. Am. Chem. Soc. 2013, 135, 12964. • One of the top 10 most downloaded papers for September 2013 • Featured in Synfacts 2013, 1143; selected by editors as “Synfact of the Month” • Covered in Chemistry World magazine A. P. Brucks, D. S. Treitler, S.-A. Liu, S. A. Snyder. Explorations into the Potential of Chiral Sulfonium Reagent to Effect Asymmetric Halonium Additions to Isolated Alkenes. Synthesis 2013, 45, 1886. • Special invited submission in honor of Prof. Scott Denmark’s 60th birthday A. M. ElSohly, D. A. Wespe, T. J. Poore, S. A. Snyder. An Efficient Approach to the Securinega Alkaloids Empowered by Cooperative N-Heterocyclic Carbene/Lewis Acid Catalysis. Angew. Chem. Int. Ed. 2013, 52, 5789. D. S. Treitler, Z. Li, M. Krystal, M. Krystal, N. A. Meanwell, S. A. Snyder. Evaluation of HIV-1 inhibition by stereoisomers and analogues of the sesquiterpenoid hydroquinone peyssonol A. Bioorg. Med. Chem. Lett. 2013, 23, 2192. S. A. Snyder, A. P. Brucks, D. S. Treitler, I. Moga. Concise Synthetic Approaches for the Laurencia Family: Formal Total Syntheses of (±)-Laurefucin and (±)-E- and (±)-ZPinnatifidenyne.J. Am. Chem. Soc. 2012, 134, 17714. • One of the top 5 most downloaded papers for October 2012 S. A. Snyder, S. B. Thomas, A. C. Mayer, S. P. Breazzano. Total Syntheses of Hopeanol and Hopeahainol D Empowered by a Chiral Bronsted-acid Induced Pinacol Rearrangement.Angew. Chem. Int. Ed. 2012, 51, 4080. • Highlighted in Totally Synthetic column of Chemistry World magazine S. A. Snyder, Z. G. Brill. Structural Revision and Total Synthesis of Caraphenol B and C.Org. Lett. 2011, 13, 5524. S. A. Snyder, D. S. Treitler, A. P. Brucks, W. I. Sattler. A General Strategy for the Stereocontrolled Preparation of Diverse 8- and 9-Membered Laurencia-type Bromoethers. J.Am. Chem. Soc. 2011, 133, 15898. S. A. Snyder, N. E. Wright, J. J. Pflueger, S. P. Breazzano. Total Syntheses of Heimiol A,Hopeahainol D, and Constrained Analogues. Angew. Chem. Int. Ed. 2011, 50, 8629. S. A. Snyder, A. Gollner, M. I. Chiriac. Regioselective Reactions for Programmable Resveratrol Oligomer Synthesis. Nature 2011, 474, 461. • Highlighted in Chemistry and Engineering News as News of the Week • Highlighted in Nature: Chemistry, Chemistry World, and several newspapers S. A. Snyder, D. A. Wespe, J. M. von Hof. A Concise, Stereocontrolled Total Synthesis of Rippertenol. J. Am. Chem. Soc. 2011, 133, 8850. • Highlighted in Totally Synthetic column of Chemistry World magazine • One of the Five Most Accessed Articles for May 2011 S. A. Snyder, F. Kontes, A. M. ElSohly. Mechanistic Investigations of the Cyclocondensation Step of the Knorr Pyrrole Synthesis. Heterocycles 2011, 84, 265. • Invited submission in honor of Prof. Albert Padwa’s 75th Birthday S. A. Snyder, F. Kontes. Synthetic Studies of Biomimetic Diels–Alder Processes towards the Helicterin Family of Natural Products. Isr. J. Chem. 2011, 51, 378. • Invited submission for a Special Issue on the Total Synthesis of Natural Products S. A. Snyder, D. S. Treitler. Synthesis of Et2SBr•SbCl5Br and its use in Biomimetic Brominative Polyene Cyclizations. Organic Syntheses 2011, 88, 54. S. A Snyder, A. M. ElSohly, F. Kontes. Synthetic and Theoretical Investigations of Myrmicarin Biosynthesis. Angew. Chem. Int. Ed. 2010, 49, 9693.