Shenvi, Ryan - The Scripps Research Institute

个人简介

Professor, The Scripps Research Institute, 2019-present Associate Professor, The Scripps Research Institute, 2014-2019 Assistant Professor, The Scripps Research Institute, 2010-2014 NIH Postdoctoral Fellow, Harvard University (E.J. Corey), 2008-2010 Ph.D., The Scripps Research Institute (P.S. Baran), 2003-2008 B.S., Pennsylvania State University (R.L. Funk), 1999-2003 Awards and Honors Mukaiyama Award, Society of Synthetic Organic Chemistry (Japan), 2024 Royal Chemical Society ChemSocRev Pioneering Investigator, 2022-2023 Tetrahedron Editor’s Choice Award (Elsevier), 2021 E. J. Corey Award (ACS) (2021) Blavatnik Award Finalist, Chemistry (2020) Tetrahedron Young Investigator Award (2019) Society of Synthetic Organic Chemistry (Japan) Lectureship Award (2017) NPR Emerging Investigator (2016) Eli Lilly Grantee Award (2015) Novartis Early Career Award (2014) BMS Unrestricted Grant in Synthetic Organic Chemistry Award (2014) NSF Career Award (2014) Alfred P. Sloan Research Fellow (2014) Baxter Foundation Young Investigator Award (2013) Amgen Young Investigator Award (2013) Boehringer Ingelheim New Investigator Award (2012) Eli Lilly New Faculty Award (2011) NIH Ruth L. Kirschstein Fellow, Harvard University (2008-2010) Roche Excellence in Chemistry Award (2007) Lesly Starr Shelton Award for Excellence in Graduate Studies (2007) NDSEG Predoctoral Fellow, TSRI (2005-2008) Poster Session Winner, TSRI Scientific Retreat (2006) PSU Sponsors Poster Session, Undergraduate Winner (2003) Pfizer Summer Undergraduate Research Fellowship (2002) John and Elizabeth Holmes Teas Scholarship (2001) William G. and Elizabeth K. Leitzell Scholarship (2000) National Merit Corporate Scholarship (1999–2003)

研究领域

Nature is molecular. Organisms comprise and produce collections of molecules unparalleled in number and diversity. These natural products, most often secondary metabolites, form the foundation of both Western and Eastern medicine – aspirin, morphine and penicillin; artemisinin (qinghaosu), ephedrine (má huáng) and other components of herbal remedies. Nature is not very organized, at least not for drug development. Molecules with promising therapeutic profiles can be buried among millions of more abundant cellular products. Or, if abundant and easily purified, these molecules can be inconveniently complex to subject to a rational medicinal chemistry campaign. Our laboratory invents chemistry to assemble simple chemical feedstocks into secondary metabolites that present interesting biological questions or hold therapeutic potential. We can turn industrial waste into medicine using chemistry.

近期论文

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Shenvi, R. A. Natural product synthesis in the 21st century: beyond the mountain top ACS Cent. Sci. 2024, online. Tong, G.; Griffin, S.; Sader, A.; Crowell, A. B.; Beavers, K.; Watson, J.; Buchan, Z.; Chen, S.; Shenvi, R. A. C5 Methylation Confers Accessibility, Stability and Selectivity to Picrotoxinin Nature Commun. 2023, 14, 8308. Gan, X.-c.;† Zhang, B.;† Dao, N.;† Bi, C.; Pokle, M.; Kan, L.; Collins, M. R.; Tyrol, C. C.; Bolduc, P. N.; Nicastri, M.; Kawamata, Y.; Baran, P. S.; Shenvi, R. A. Carbon Quaternization of Redox Active Esters and Olefins via Decarboxylative Coupling. Science (accepted). van der Puyl-Lovett;† V. A.; Gan, X.-c.;† Kong, L.;† Shenvi, R. A. Alkene hydrobenzylation by a single catalyst that mediates iterative outer-sphere steps. J. Am. Chem. Soc. 2024, 146, 2351. Kotesova, S.; Shenvi, R. A. Inner- and outer-sphere cross-couplings for high Fsp3 fragments in natural product space. Acc. Chem. Res. 2023, 56, 3089. Ting, S.;† Snelson, D.;† Huffman, T. R.; Kuroo, A.; Sato, R.; Shenvi, R. A. Synthesis of (–)-cotylenol, a 14-3-3 molecular glue component. J. Am. Chem. Soc. 2023, 145, 20634. †co-first authors Gan, X.-c.;§ Kotesova, S.;§ Castanedo, A.; Green, S. A.; Møller, S. L. B.; Shenvi, R. A. Iron-catalyzed hydrobenzylation: stereoselective synthesis of (–)-eugenial C. J. Am. Chem. Soc. 2023, 145, 15714. §co-first authors Hill, S. J.§; Dao, N.§; Dang, V.; Stahl, E.; Bohn, L. Shenvi, R. A. A route to potent, selective and biased salvinorin chemical space. ACS Cent. Sci., 2023, online. §co-first authors Shenvi, R. A. Early Childhood Care as an Academic: The Slow Burn. Angew. Chem. Int. Ed., 2023, in press [Ihr verborgenes Leben (Their Hidden Lives) Essay Series]. van der Puyl, V. A.; Shenvi, R. A. Manganese, iron and cobalt-catalyzed radical olefin hydrofunctionalization Science of Synthesis, 2.14: Base Metal Catalysis, 2023, Ed. N. Yoshikai. Woo, S.; Landwehr, E.; Shenvi, R. A. Synthesis of psychotropic alkaloids from Galbulimima Tetrahedron 2022, 126, 133064. [In celebration of the 65th anniversary of Tetrahedron Publications] Shevick, S. L.; Freeman, S.; Tong, G.; Russo, R. J.; Bohn, L. M.; Shenvi, R. A. Asymmetric syntheses of (+)- and (–)-collybolide enable re-evaluation of kappa-opioid receptor agonism ACS Cent. Sci. 2022, accepted. Woo, S.; Shenvi, R. A. Synthesis and target annotation of GB18. Nature, 2022, DOI: 10.1038/s41586-022-04840-9. Landwehr, E. M.; Baker, M. A.; Oguma, T.; Burdge, H. E.; Kawajiri, T.; Shenvi, R. A. Concise syntheses of GB22, GB13 and himgaline by cross-coupling and complete reduction. Science, 2022, 375, 1270–1274. Huffman, B. J.; Chu, T.; Chen, S.; Shenvi, R. A. Stereodivergent attached ring synthesis via non-covalent interactions: a short formal synthesis of merrilactone A Angew. Chem. Int. Ed. 2022, 61, e202114514. Tong, G.; Shenvi, R. A. Revision of the unstable picrotoxinin hydrolysis product Angew. Chem. Int. Ed. 2021, 60, 19113. van der Puyl, V.; McCourt, R. O.; Shenvi, R. A. Cobalt-catalyzed alkene hydrogenation by reductive turnover Tetrahedron Lett. 2021, 72, 153047. On the occasion of the 2020 Tetrahedron Prize to Dale Boger. Woo, S.; Shenvi, R. A. Natural Product Synthesis through the Lens of Informatics Acc. Chem. Res. 2021, online. Tong, G.; Baker, M. A.; Shenvi, R. A. Change the channel: CysLoop receptor antagonists from Nature. Pest Manag. Sci. 2020, accepted. [Special Issue honoring Tom Sparks for the Kenneth Spencer Award] Shevick, S. L.; Wilson, C. V.; Kotesova, S.; Kim, D.; Holland, P. L.; Shenvi, R. A. Catalytic hydrogen atom transfer to alkenes: a roadmap for metal hydrides and radicals. Chem. Sci. 2020, 12401–12422. Demoret, R. M.; Baker, M. A.; Ohtawa, M.; Chen, S.; Lam, C.-C.; Khom, S.; Roberto, M.; Forli, S.; Houk, K.; Shenvi, R. A. Synthetic, Mechanistic and Biological Interrogation of Ginkgo biloba Chemical Space en route to (–)-Bilobalide. J. Am. Chem. Soc. 2020, 142, 18599–18618.ChemRxiv DOI: 10.26434/ chemrxiv.12132939.v2 Hill, S. J.; Brion, A. U. C. M.; Shenvi, R. A. Chemical Syntheses of the salvinorin chemotype of KOR agonist. Nat. Prod. Rep. 2020, online. Crossley, S. W. M.; Tong, G.; Lambrecht, M. J.; Burdge, H. E.; Shenvi, R. A. Total Synthesis of (–)-Picrotoxinin J. Am. Chem. Soc. 2020, 142, 11376–11381. Matos, J. L. M.; Green, S. A.; Chun, Y; Dang, V. Q.; Dushin, R. G.; Richardson, P.; Chen, J. S.; Piotrowski, D. W.; Paegel, B. M.; Shenvi, R. A. Cycloisomerization of olefins in water, Angew. Chem. Int. Ed. 2020, 59, 12998–13003. Burdge, H. E.; Oguma, T.; Kawajiri, T.; Shenvi, R. A. Concise Synthesis of GB22 by Endo-Selective Siloxycyclopropane Arylation ChemRxiv DOI: 10.26434/chemrxiv.8263415.v1 . Huffman, B. J.; Chen, S.; Schwarz, J. L; Plata, R. E.; Chin, E.; Houk, K. N.; Lairson, L. L.; Shenvi, R. A. Electronic Complementarity Permits Hindered Butenolide Heterodimerization and Discovery of Novel cGAS/STING Pathway Antagonists, Nature Chem. 2020, 12, 310–317. Shevick, S. L.; Baker, M. A.; Shenvi, R. A. Alkene Hydroarylation by Co/Ni Dual Catalysis, Cell: Trends in Chemistry, 2019, 1, 540–541. Matos, J. L. M.; Green, S. A.; Shenvi, R. A. Chapter 7. Markovnikov Functionalization by Hydrogen Atom Transfer, Organic Reactions, 2019, 100, 383–470. Baker, M.; Demoret, R.; Ohtawa, M.; Shenvi, R. A. Concise Asymmetric Synthesis of (–)-Bilobalide Nature 2019, 575, 643–646. DOI: 10.1038/s41586-019-1690-5. ChemRxiv DOI: 10.26434/chemrxiv.8202053.v1 Featured in Org. Chem. Highlights Green, S. A.; Huffman, T. R.; McCourt, R. O.; van der Puyl, V.; Shenvi, R. A. Hydroalkylation of Olefins to form Quaternary Carbons J. Am. Chem. Soc. 2019, 141, 7709-7714. Martinez, R.; Burdge, H.; Shenvi, R. A. Reanalysis of Lindenatriene, a Building Block for the Synthesis of Lindenane Oligomers Tetrahedron 2019, 75, 3140-3144. [invited manuscript for Ryan's Tetrahedron Young Investigator Award 2019]