Mooney, David - Harvard University - John A. Paulson School of Engineering and Applied Sciences

个人简介

Education BS, Chemical Engineering, University of Wisconsin, Madison PhD, Chemical Engineering, Massachusetts Institute of Technology (Advisors: Drs. Robert Langer and Donald Ingber) Post-doctoral Studies, Harvard Medical School (Advisor: Dr. Joseph Vacanti) Recent Awards and Recognitions 2017: National Academy of Inventors (NAI) 2016: Mercator Fellow (DFG; Charite Hospital Berlin) 2015: International ICMS Chair in Biology, Eindhoven University 2014: Capers and Marion McDonald Award for Excellence in Mentoring and Advising (Harvard University) 2013: Institute of Medicine of the National Academies (IOM) Dave is a leader in the fields of biomaterials, mechanotransduction, drug delivery, tissue engineering and immunoengineering. He is interested in understanding how cells sense signals in their environment and how this alters cell behavior. His laboratory develops biomaterials that exploits these signals to regulate specific cells and their function. They were the first to demonstrate in 3-D culture that the mechanical properties of a substrate regulated stem cell fate. His lab also developed the first implantable biomaterial cancer vaccine that contained biochemical cues to recruit and re-educate the immune system to destroy cancer cells. Dave’s goal is to use our knowledge of cell biology in conjunction with materials to boost therapeutic effects. Dave is the Robert Pinkas Family Professor of Bioengineering in the Harvard School of Engineering and Applied Sciences, and a Core Faculty Member of the Wyss Institute at Harvard University. He is a member of several national academies and has won numerous awards for his research and his mentorship/teaching. He has published over 400 articles and has been issued numerous patents, several of which have been licensed to companies, resulting in successful commercial products. He is also an active member in major engineering professional societies, an editorial advisor to multiple journals, and serves on several industry and government advisory boards.

研究领域

Our laboratory aims to make cellular and molecular therapies more effective and practical approaches to treat disease. Basic science studies are used to study the mechanisms by which chemical or mechanical signals are sensed by cells and alter cell function. The results of these studies are then used to design new biomaterials that provide desirable cues in a spatiotemporally-regulated manner to modulate the gene expression of interacting cells. These biomaterials are used in a variety of drug delivery, immunotherapy, and regenerative medicine projects to promote the regeneration or targeted destruction of tissues and organs in the body. RESEARCH Drug Delivery Immunotherapy Mechanotransduction and Mechanotherapy Tissue Engineering and Regenerative Medicine New Biomaterials

近期论文

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Grolman JM, Singh M, Mooney DJ, Eriksson E, Nuutila K. Antibiotic containing agarose hydrogel for wound and burn care. J Burn Care Res. 2019.Abstract Blacklow SO, Li J, Freedman BR, Zeidi M, Chen C, Mooney DJ. Bioinspired mechanically active adhesive dressings to accelerate wound closure. Sci Adv. 2019;5 (7) :eaaw3963.Abstract Lueckgen A, Garske DS, Ellinghaus A, Mooney DJ, Duda GN, Cipitria A. Enzymatically-degradable alginate hydrogels promote cell spreading and in vivo tissue infiltration. Biomaterials. 2019;217 :119294.Abstract Raimondo TM, Li H, Kwee BJ, Kinsley S, Budina E, Anderson EM, Doherty EJ, Talbot SG, Mooney DJ. Combined delivery of VEGF and IGF-1 promotes functional innervation in mice and improves muscle transplantation in rabbits. Biomaterials. 2019;216 :119246.Abstract Yang J, Bai R, Li J, Yang CH, Yao X, Liu Q, Vlassak JJ, Mooney DJ, Suo Z. Design molecular topology for wet-dry adhesion. ACS Appl Mater Interfaces. 2019.Abstract Zohar B, Blinder Y, Epshtein M, Szklanny AA, Kaplan B, Korin N, Mooney DJ, Levenberg S. Multi-flow channel bioreactor enables real-time monitoring of cellular dynamics in 3D engineered tissue. Commun Biol. 2019;2 :158.Abstract Freedman BR, Mooney DJ. Biomaterials to Mimic and Heal Connective Tissues. Adv Mater. 2019 :e1806695.Abstract Özkale B, Parreira R, Bekdemir A, Pancaldi L, Özelçi E, Amadio C, Kaynak M, Stellacci F, Mooney DJ, Sakar MS. Modular soft robotic microdevices for dexterous biomanipulation. Lab Chip. 2019;19 (5) :778-788.Abstract Vining KH, Stafford A, Mooney DJ. Sequential modes of crosslinking tune viscoelasticity of cell-instructive hydrogels. Biomaterials. 2019;188 :187-197.Abstract Whyte W, Roche ET, Varela CE, Mendez K, Islam S, O'Neill H, Weafer F, Shirazi RN, Weaver JC, Vasilyev NV, et al. Sustained release of targeted cardiac therapy with a replenishable implanted epicardial reservoir. Nat Biomed Eng. 2018;2 (6) :416-428.Abstract Raimondo TM, Mooney DJ. Functional muscle recovery with nanoparticle-directed M2 macrophage polarization in mice. Proc Natl Acad Sci U S A. 2018;115 (42) :10648-10653.Abstract Wang H, Mooney DJ. Biomaterial-assisted targeted modulation of immune cells in cancer treatment. Nat Mater. 2018;17 (9) :761-772.Abstract Lueckgen A, Garske DS, Ellinghaus A, Desai RM, Stafford AG, Mooney DJ, Duda GN, Cipitria A. Hydrolytically-degradable click-crosslinked alginate hydrogels. Biomaterials. 2018;181 :189-198.Abstract Darnell M, O'Neil A, Mao A, Gu L, Rubin LL, Mooney DJ. Material microenvironmental properties couple to induce distinct transcriptional programs in mammalian stem cells. Proc Natl Acad Sci U S A. 2018;115 (36) :E8368-E8377.Abstract Darnell M, Gu L, Mooney D. RNA-seq reveals diverse effects of substrate stiffness on mesenchymal stem cells. Biomaterials. 2018;181 :182-188.Abstract