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Yingying Meng,† Ji Gao,† Peirong Zhou, Xudong Qin, Miao Tian, Xiaohui Wang, Cheng Zhou,* Kai Li,* Fei Huang,* Yong Cao. NIR-II conjugated electrolytes as biomimetics of lipid bilayers for in vivo liposome tracking. Angew. Chem. Int. Ed. 2024, e202318632 .
Ji Gao,† Weijun Wu,† Lulu Zhou,† Shaokuan Gong, Chong Li, Xihan Chen,* Yiming Li,* Kai Li.* Facile blinking dyes with spontaneous enol-keto tautomerism for super-resolution imaging of subcellular targets. CCS Chem. 2024, Accepted .
Chong Li,† Minghao Han,† Ji Gao,† Shuxian Wang,† Song-Bo Lu, Yaxi Li, Zhao Liu, Chen Zhang, Zhaojin Wang, Fangliang Wang, Yang Sun, Chun Loong Ho, Kai Wang, Yun Shen, Kai Li.* Enhancing photodynamic inactivation via tunning spatial constraint on photosensitizer. Sci. China Chem. 2024, 67, 652-663 .
Wenxing Gu,† Jingnan An,† Yaxi Li, Yajie Yang, Shumin Wang, Hui Shan, Shenhua Li, Hui Li, Guoyong Liu, Kai Li,* Yuxin Yin, Jing Mu,* Xiaoyuan Chen.* Tuning the organ tropism of polymersome for spleen-selective nanovaccine delivery to boost cancer immunotherapy. Adv. Mater. 2023, 35, e2301686 .
Huilin Xie,† Chen Zhang,† Tingting Li,† Lianrui Hu, Jianquan Zhang, Heng Guo, Zhao Liu, Dinglu Peng, Zeshun Li, Weijun Wu, Ji Gao, Zhenyu Bi, Jinghan Wang, Pengfei Zhang, Ryan T. K. Kwok, Jacky W. Y. Lam, Zhihong Guo, Lei Xi,* Kai Li,* Ben Zhong Tang.* Fast delivery of multifunctional NIR-II theranostic nanoaggregates enabled by the photoinduced thermoacoustic process, Adv. Sci. 2023, 10, 2301104 .
Huilin Xie,† Zhenyu Bi,† Junli Yin, Zeshun Li, Lianrui Hu, Chen Zhang, Jianquan Zhang, Jacky W. Y. Lam, Pengfei Zhang, Ryan T. K. Kwok,* Kai Li,* Ben Zhong Tang.* Design of one-for-all near-infrared aggregation-induced emission nanoaggregates for boosting theranostic efficacy. ACS Nano 2023, 17, 4591-4600 .
Guoyong Liu,† Shuxian Wang,† Shumin Wang, Rongrong Wu, Hui Li, Menglei Zha, Jibin Song, Yuxin Yin, Kai Li,* Jing Mu,* Yu Shi.* Carbon dots‑mediated synthesis of gold nanodendrites with extended absorption into NIR‑II window for in vivo photothermal therapy. J. Nanobiotechnol. 2023, 21, 151 .
Jun Wang,† Qinzhen Li,† Hui Zhao, Wentong Yue, Kaiwen Zhang, Xingyu Jiang,* Kai Li.* Facile and controllable synthesis of the renal-clearable “luminous pearls” for in vivo afterglow/magnetic resonance imaging. ACS Nano 2022, 16, 462-472 .
Jun, Wang,† Menglei Zha,† Hui Zhao,† Wentong Yue, Decheng Wu, Kai Li.* Detection of kidney dysfunction through in vivo magnetic resonance imaging with renal-clearable gadolinium nanoprobes. Anal. Chem. 2022, 94, 4005-4011 .
Chengyu Yang,† Zeshun Li,† Yang Liu, Runpeng Hou, Minmin Lin, Linhao Fu, Decheng Wu, Quanying Liu, Kai Li,* Chao Liu.* Single-cell spatiotemporal analysis reveals cell fates and functions of transplanted mesenchymal stromal cells during bone repair. Stem Cell Rep. 2022, doi: 10.1016/j.stemcr.2022.08.008 .
Xinyue Liu,† Chen Zhang,† Lianrui Hu, Jinghuan Wang, Kai Li,* Hai-Tao Feng, Jacky W. Y. Lam,* Benzhao He,* Ben Zhong Tang.* “On water” effect for green click reaction: spontaneous polymerization of activated alkyne with “inert” aromatic amine in aqueous media. CCS Chem. 2023, 5, 385-396 .
Song-Bo Lu, Luyao Wei, Wenjing He, Zhen-Yu Bi, Yuhan Qian, Jinghan Wang, Hongqiu Lei, Kai Li.* Recent advances in the enzyme-activatable organic fluorescent probes for tumor imaging and therapy. ChemistryOpen 2022, 11, e202200137.
Yaxi Li,† Menglei Zha,† Tianyi Kang, Chong Li, Xue Wu, Shuxian Wang, Song-Bo Lu, Yi-Shan Lee, Yun-Rong Wu, Jen-Shyang Ni,* Kai Li.* Promoted NIR-II fluorescence by heteroatom-inserted rigid-planar cores for monitoring cell therapy of acute lung injury. Small 2022, 18, 2270006 .
Cheng Zhou,† Zeshun Li,† Ziyue Zhu, Geraldine W. N. Chia, Alexander Mikhailovsky, Ricardo Javier Vázquez, Samuel J. W. Chan, Kai Li,* Bin Liu,* Guillermo C. Bazan.* Conjugated oligoelectrolytes for long-term tumor tracking with incremental NIR-II emission. Adv. Mater. 2022, 34, 2201989 .
Duyang Gao, Yaxi Li, Yayun Wu, Yu Liu, Dehong Hu, Simin Liang, Jiuling Liao, Min Pan, Pengfei Zhang, Kai Li, Xin Liu, Hairong Zheng, Zonghai Sheng, ACS Appl. Mater. Interfaces 2022, doi: 10.1021/acsami.1c22700 .
Guang Yang,† Jen-Shyang Ni,† Yaxi Li, Menglei Zha, Yao Tu, Kai Li.* Acceptor engineering for optimized ROS generation facilitates reprogramming macrophages to M1 phenotype in photodynamic immunotherapy. Angew. Chem. Int. Ed. 2021, 60, 5386-5393 .
Guang Yang,† Song-Bo Lu,† Chong Li, Feng Chen, Jen-Shyang Ni, Menglei Zha, Yaxi Li, Ji Gao, Tianyi Kang, Chao Liu, Kai Li.* Type I macrophage activator photosensitizer against hypoxic tumor. Chem. Sci. 2021, 12, 14773-14780. .
Yaxi Li,† Hongli Zhou,† Renzhe Bi, Xiuting Li, Menglei Zha, Yanqing Yang, Jen-Shyang Ni, Weng Heng Liew, Malini Olivo, Kui Yao, Jie Liu,* Hao Chen,* Kai Li.* Acceptor engineering of small molecule fluorophores for NIR-II fluorescent and photoacoustic imaging. J. Mater. Chem. B 2021, 9, 9951-9960 .
Tianyi Kang,† Jen-Shyang Ni,† Tingting Li, Jun Wang, Zeshun Li, Yaxi Li, Menglei Zha, Chen Zhang, Xue Wu, Heng Guo, Lei Xi, Kai Li.* Efficient and precise delivery of microRNA by photoacoustic force generated from semiconducting polymer-based nanocarriers. Biomaterials 2021, 275, 120907 .
Fei Ren,† Zeshun Li,† Kai Li,* Xiaoyan Zheng,* Jianbing Shi,* Chen Zhang, Heng Guo, Bin Tong, Lei Xi, Zhengxu Cai, Yuping Dong.* Donor strategy for promoting nonradiative decay to achieve an efficient photothermal therapy for treating cancer. Sci. China Chem. 2021, 64, 1530-1539 .
Menglei Zha, Guang Yang,* Yaxi Li, Chen Zhang, Bo Li,* Kai Li.* Recent advances in AIEgen-based photodynamic therapy and immunotherapy. Adv. Healthcare Mater. 2021, 10, 2101066 (Invited Review).
Weizhi Qi,† Tingting Li,† Chen Zhang,† Fei Liu, Jun Wang, Dandan Chen, Xiaofeng Fang, Changfeng Wu,* Kai Li,* Lei Xi.* Light-controlled precise delivery of NIR-responsive semiconducting polymer nanoparticles with promoted vascular permeability. Adv. Healthcare Mater. 2021, 10, 2100569 .
Yaxi Li,† Menglei Zha,† Guang Yang, Shuxian Wang, Jen-Shyang Ni,* Kai Li.* NIR-II fluorescent brightness promoted by “ring fusion” for the detection of intestinal inflammation. Chem. Eur. J. 2021, 27, 13085-13091.
Zeshun Li,† Tingting Li,† Chen Zhang,† Jen-Shyang Ni, Yaoyao Ji, Aihui Sun, Dinglu Peng, Weijun Wu, Lei Xi,* Kai Li.* A multispectral photoacoustic tracking strategy for wide-field and real-time monitoring of macrophages in inflammation. Anal. Chem. 2021, 93, 8467-8475 .
Hao Chen,† Huaxiao Yang,† Chen Zhang, Si Chen, Xin Zhao, Mark Zhu, Zhiming Wang, Yuebing Wang, Hung-Ta Wo, Kai Li,* Zhen Cheng.* Differential responses of transplanted stem cells to diseased environment unveiled by a molecular NIR-II cell tracker. Research 2021, 2021, 9798580 .
Yaxi Li,† Zeshun Li,† Dehong Hu,† Shuxian Wang, Menglei Zha, Song-Bo Lu, Zonghai Sheng, Kai Li.* Targeted NIR-II emissive nanoprobes for tumor detection in mice and rabbits. Chem. Commun. 2021, 57, 6420-6423 .
Jun Wang,† Tingting Li,† Jen-Shyang Ni,† Heng Guo, Tianyi Kang, Zeshun Li, Menglei Zha, Songbo Lu, Chen Zhang, Weizhi Qi, Lei Xi,* Kai Li.* Photoacoustic force-guided precise and fast delivery of nanomedicine with boosted therapeutic efficacy. Adv. Sci. 2021, 8, 2100228 .
Yaxi Li,† Dehong Hu,† Zonghai Sheng, Tianliang Min, Menglei Zha, Jen-Shyang Ni, Hairong Zheng,* Kai Li.* Self-assembled AIEgen nanoparticles for multiscale NIR-II vascular imaging. Biomaterials 2021, 264, 120365 (†contributed equally, Highly Cited).
Wei Zhu,† Miaomiao Kang,† Qian Wu, Zhijun Zhang, Yi Wu, Chunbin Li, Kai Li,* Lei Wang, Domng Wang,* Ben Zhong Tang.* Zwitterionic AIEgens: rational molecular design for NIR-II fluorescence imaging-guided synergistic phototherapy. Adv. Funct. Mater. 2021, 31, 202007026 .
Yan-Long Ma,† Chen Sun,† Zeshun Li, Ziyi Wang, Jianwen Wei, Qian Cheng, Li-Shuo Zheng, Xiao-Yong Chang, Kai Li, Ruibing Wang,* Wei Jiang,* Biomimetic recognition-based biorthogonal host-guest pairs for cell targeting and tissue imaging in living animals. CCS Chem. 2021, 3, 2143-2155 .
Aihui Sun, Tingting Li, Tian Jin, Yaxi Li, Kai Li, Chaolong Song, Lei Xi,*Acoustic standing wave aided multiparametric photoacoustic imaging flow cytometry. Anal. Chem. 2021, 93, 14820-14827.
Tian Jin, Chen Zhang, Fei Liu, Xingxing Chen, Guangru Liang, Fei Ren, Suzi Liang, Chaolong Song, Jianbing Shi, Weibao Qiu, Xingyu Jiang, Kai Li, Lei Xi,* On-chip multicolor photoacoustic imaging flow cytometry. Anal. Chem. 2021, 93, 8134-8142.
Xun Zhang,† Yanqing Yang,† Tianyi Kang, Jun Wang, Guang Yang, Yuming Yang, Xiangwei Lin, Lidai Wang, Kai Li, Jie Liu,* Jen-Shyang Ni,* NIR‐II absorbing semiconducting polymer‐triggered gene‐directed enzyme prodrug therapy for cancer treatment. Small 2021, 17, e2100501 .
Haifei Wen, Zhijun Zhang,* Miaomiao Kang, Haoxuan Li, Wenhan Xu, Heng Guo, Youmei Li, Yonghong Tan, Ziyao Wen, Qian Wu, Jiachang Huang, Lei Xi, Kai Li, Lei Wang, Dong Wang,* Ben Zhong Tang,* One-for-all phototheranostics: single component AIE dots as multi-modality theranostic agent for fluorescence-photoacoustic imaging-guided synergistic cancer therapy. Biomaterials 2021, 274, 120892.
Zonghai Sheng, Yaxi Li, Dehong Hu, Tianliang Min, Duyang Gao, Jen-Shyang Ni, Pengfei Zhang, Yuenan Wang, Xin Liu, Kai Li,* Hairong Zheng,* Ben Zhong Tang.* Centimeter-deep NIR-II fluorescence imaging with nontoxic AIE probes in non-human primates. Research 2020, 2020, 4074593.
Menglei Zha,† Xiangwei Lin,† Jen-Shyang Ni,†,* Yaxi Li, Yachao Zhang, Xun Zhang, Lidai Wang,* Kai Li.* An ester-substituted semiconducting polymer with efficient nonradiative decay enhances NIR-II photoacoustic performance for monitoring of tumor growth. Angew. Chem. Int. Ed. 2020, 59, 23268-23276 .
Xuanyu Li,† Menglei Zha,† Yaxi Li, Jen-Shyang Ni, Tianliang Min, Tianyi Kang, Guang Yang, Hao Tang, Kai Li,* Xingyu Jiang.* Sub-10 nm aggregation-induced emission quantum dots assembled by microfluidics for enhanced tumor-targeting and reduced retention in the liver. Angew. Chem. Int. Ed. 2020, 59, 21899-21903 .
Jen-Shyang Ni,† Xun Zhang,† Guang Yang, Tianyi Kang, Xiangwei Lin, Menglei Zha, Yaxi Li, Lidai Wang, Kai Li.* A photoinduced nonadiabatic decay-guided molecular motor triggers effective photothermal conversion for hyperthermia cancer therapy. Angew. Chem. Int. Ed. 2020, 59, 11298-11302 .
Jen-Shyang Ni,† Tianliang Min,† Yaxi Li, Menglei Zha, Pengfei Zhang, Chun Loong Ho, Kai Li.* Planar AIEgens with enhanced solid-state luminescence and ROS-generation for multidrug-resistant bacteria treatment. Angew. Chem. Int. Ed. 2020, 59, 10179-10185 .
Jen-Shyang Ni,† Yaxi Li,† Wentong Yue, Bin Liu,* Kai Li.* Nanoparticle-based cell trackers for biomedical applications. Theranostics 2020, 10, 1923-1947 .
Zhijun Zhang, Wenhua Xu, Miaomiao Kang, Haifei Wen, Heng Guo, Pengfei Zhang, Lei Xi, Kai Li, Lei Wang, Dong Wang,* Ben Zhong Tang.* An all‐round athlete on the track of phototheranostics: subtly regulating the balance between radiative and nonradiative decays for multimodal imaging‐guided synergistic therapy. Adv. Mater. 2020, 32, 2003210.
Jiachang Huang, Benzhao He, Zhijun Zhang, Youmei Li, Miaomiao Kang, Yuanwei Wang, Kai Li, Dong Wang,* Ben Zhong Tang,* Aggregation‐induced emission luminogens married to 2D black phosphorus nanosheets for highly efficient multimodal theranostics. Adv. Mater. 2020, 32, 2003382.
Wenhan Xu,† Zhijun Zhang,† Miaomiao Kang, Heng Guo, Youmei Li, Haifei Wen, Michelle M. S. Lee, Zhaoyu Wang, Ryan T. K. Kwok, Jacky W. Y. Lam, Kai Li, Lei Xi*, Sijie Chen, Dong Wang*, Ben Zhong Tang.* Making the best use of excited-state energy: Multimodality theranostic systems based on second near-infrared (NIR-II) aggregation-induced emission luminogens (AIEgens). ACS Materials Lett. 2020, 2, 1033-1040 .
Qiyao Li,† Ying Li,† Tianliang Min,† Junyi Gong, Lili Du, David Lee Phillips, Junkai Liu, Jacky W. Y. Lam, Herman H. Y. Sung, Ian D. Williams, Ryan T. K. Kwok, Chun Loong Ho, Kai Li, Jianguo Wang,* Ben Zhong Tang.* Time‐dependent photodynamic therapy for multiple targets: a highly efficient AIE‐active photosensitizer for selective bacterial elimination and cancer cell ablation. Angew. Chem. Int. Ed. 2020, 59, 9470-9477 .
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