Qin, Lidong - Houston Methodist Research Institute -

个人简介

BIOGRAPHY Dr. Qin received his Ph.D. in Chemistry from Northwestern University, Evanston, Illinois and completed a postdoctoral traineeship in Cancer Nanotechnology at the California Institute of Technology. In Prof. Chad Mirkin's lab at the Northwestern University, Dr. Qin worked on functional metallic nanorods, with the invention of on-wire lithography and the development of Raman spectrum-based imaging and sensing methods. His research provided insightful understanding of Surface Enhanced Raman Spectroscopy and Surface Plasmon Resonance, which are the basics of Raman-based cancer imaging and nanomaterial-based cancer thermal therapeutics. Because of his pioneering work in metal nanomaterial synthesis and biological applications, he was awarded the International Precious Metal Institute (IPMI) graduate student prize. His other awards include the Materials Research Society graduate student award, Chinese government award for graduate students studying abroad, and Searle center for teaching excellence award. During his four years at Northwestern University, Dr. Qin received eight patents and published fourteen peer-reviewed journal articles, in journals including Science, PNAS, JACS and Nano Letters. Later, Dr. Qin moved to Caltech as a postdoctoral fellow, working with Prof. James Heath. He developed automatic proteomic barcode chips that allow highly multiplexed plasma cancer biomarker measurements from a finger-prick of blood. Dr. Qin's method is recognized as a significant improvement over the cost and speed of standard laboratory tests to analyze proteins in blood. In his three-year postdoctoral research position, he also worked on integrated microfluidic chips to handle prostate cancer cell culture and study proteomic profiles from individual cells. He continued to excel and make major contributions to his field, receiving another patent and publishing three peer-reviewed papers in Nature Nanotechnology, Lab on a Chip and Nature Biotechnology. Dr. Qin joined the TMHRI Department of Nanomedicine in July 2010 and was awarded with a prestigious startup award, the Cancer Prevention and Research Institute of Texas (CPRIT) recruitment award for first-time, tenure-track faculty. EDUCATION & TRAINING MS, Jilin University Postdoctoral Fellowship, NanoSystems Biology Cancer Center, California Institute of Technology, Pasadena, CA PhD, Northwestern U.

研究领域

Translational cancer medicine is the focus of my research group. In particular, we develop nonconventional technology platforms for cancer diagnosis and risk analysis, measurement of cancer cell mechanical properties and phenotype enrichment, and in vitro models for study of the cancer cell microenvironment. Our technological expertise includes rational design of microfluidics platforms that allows for rapid and high-throughput molecular and cellular assays, fabrication of bio-inspired microstructures that simulate the cancer cell microenvironment, and development of nanotools that assist molecular signal amplification. Our biological targets address the cancer metastatic cascade, with focuses on cancer cell phenotype transition in the primary tumor, detection of circulating biomarkers and circulating tumor cells in the blood, and cancer cell migration and invasion at the metastatic site. The combination of our technological strengths and understanding of cancer cell biology has helped us develop several interesting technological innovations and opened many new avenues of future research direction.

近期论文

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High-Throughput Isolation of Cell Protrusions with Single-Cell Precision for Profiling Subcellular Gene Expression Zhang, P, Han, X, Yao, J, Shao, N, Zhang, K, Zhou, Y, Zu, Y, Wang, B & Qin, L 2019, Angewandte Chemie - International Edition. https://doi.org/10.1002/anie.201903694 Cellular response to moderate chromatin architectural defects promotes longevity Yu, R, Sun, L, Sun, Y, Han, X, Qin, L & Dang, W 2019, Science Advances, vol. 5, no. 7, eaav1165. https://doi.org/10.1126/sciadv.aav1165 Integrated Microfluidic Chip for Efficient Isolation and Deformability Analysis of Circulating Tumor Cells Liu, Z, Chen, R, Li, Y, Liu, J, Wang, P, Xia, X & Qin, L 2018, Advanced Biosystems, vol. 2, no. 10, 1800200. https://doi.org/10.1002/adbi.201800200 Correction to: Direct Assessment of the Toxicity of Molybdenum Disulfide Atomically Thin Film and Microparticles via Cytotoxicity and Patch Testing (Small, (2018), 14, 12, (1702600), 10.1002/smll.201702600)Chen, W, Qi, W, Lu, W, Chaudhury, NR, Yuan, J, Qin, L & Lou, J 2018, Small, vol. 14, no. 21, 1801399. https://doi.org/10.1002/smll.201801399 Analysis of the bystander effect in cone photoreceptors via a guided neural network platform Ma, Y, Han, X, De Castro, RB, Zhang, P, Zhang, K, Hu, Z & Qin, L 2018, Science Advances, vol. 4, no. 5, eaas9274. https://doi.org/10.1126/sciadv.aas9274 Direct Assessment of the Toxicity of Molybdenum Disulfide Atomically Thin Film and Microparticles via Cytotoxicity and Patch Testing Chen, W, Qi, W, Lu, W, Chaudhury, NR, Yuan, J, Qin, L & Lou, J 2018, Small, vol. 14, no. 12, 1702600. https://doi.org/10.1002/smll.201702600 PD-1 blocks lytic granule polarization with concomitant impairment of integrin outside-in signaling in the natural killer cell immunological synapse Huang, Y, Chen, Z, Jang, JH, Baig, MS, Bertolet, G, Schroeder, C, Huang, S, Hu, Q, Zhao, Y, Lewis, DE, Qin, L, Zhu, MX & Liu, D 2018, Journal of Allergy and Clinical Immunology. https://doi.org/10.1016/j.jaci.2018.02.050 Immunological Synapse Predicts Effectiveness of Chimeric Antigen Receptor Cells Xiong, W, Chen, Y, Kang, X, Chen, Z, Zheng, P, Hsu, YH, Jang, JH, Qin, L, Liu, H, Dotti, G & Liu, D 2018, Molecular Therapy. https://doi.org/10.1016/j.ymthe.2018.01.020 Microfluidics Cell Loading-Dock System: Ordered Cellular Array for Dynamic Lymphocyte-Communication Study Li, Y, Jang, JH, Wang, C, He, B, Zhang, K, Zhang, P, Vu, T & Qin, L 2017, Advanced Biosystems, vol. 1, no. 10, 1700085. https://doi.org/10.1002/adbi.201700085 Fast, Sensitive, and Quantitative Point-of-Care Platform for the Assessment of Drugs of Abuse in Urine, Serum, and Whole Blood Li, Y, Uddayasankar, U, He, B, Wang, P & Qin, L 2017, Analytical Chemistry, vol. 89, no. 16, pp. 8273-8281. https://doi.org/10.1021/acs.analchem.7b01288 Microfluidic Mapping of Cancer Cell-Protein Binding Interaction Liu, Z, Han, X, Chen, R, Zhang, K, Li, Y, Fruge, S, Jang, JH, Ma, Y & Qin, L 2017, ACS Applied Materials and Interfaces, vol. 9, no. 27, pp. 22143-22148. https://doi.org/10.1021/acsami.7b03728 Integrated Microfluidic System for Gene Silencing and Cell Migration Liu, Z, Han, X, Zhou, Q, Chen, R, Fruge, S, Jo, MC, Ma, Y, Li, Z, Yokoi, K & Qin, L 2017, Advanced biosystems, vol. 1, no. 6. https://doi.org/10.1002/adbi.201700054 Highly efficient genome editing of human hematopoietic stem cells via a nano-silicon-blade delivery approach Ma, Y, Han, X, Quintana Bustamante, O, Bessa De Castro, R, Zhang, K, Zhang, P, Li, Y, Liu, Z, Liu, X, Ferrari, M, Hu, Z, Carlos Segovia, J & Qin, L 2017, Integrative Biology (United Kingdom), vol. 9, no. 6, pp. 548-554. https://doi.org/10.1039/c7ib00060j Cas9 Ribonucleoprotein Delivery via Microfluidic Cell-Deformation Chip for Human T-Cell Genome Editing and Immunotherapy Han, X, Liu, Z, Ma, Y, Zhang, K & Qin, L 2017, Advanced Biosystems, vol. 1, no. 1-2, 1600007. https://doi.org/10.1002/adbi.201600007 Volumetric bar-chart chips for biosensing Song, Y, Li, Y & Qin, L 2017, . in Methods in Molecular Biology. vol. 1570, Methods in Molecular Biology, vol. 1570, Humana Press, pp. 105-115. https://doi.org/10.1007/978-1-4939-6840-4_7 Bridging the gap: microfluidic devices for short and long distance cell-cell communication Vu, TQ, De Castro, RMB & Qin, L 2017, Lab on a Chip - Miniaturisation for Chemistry and Biology, vol. 17, no. 6, pp. 1009-1023. https://doi.org/10.1039/c6lc01367h SINGLE-CELL PIPETTE ASSEMBLY COMPRISING SINGLE-CELL PIPETTE HANDLE AND SINGLE-CELL PIPETTE TIP QIN, L & ZHANG, K 2016, , Patent No. EP3099411, IPC No. B01L 3/ 02 A I. Single-cell isolation by a modular single-cell pipette for RNA-sequencing Zhang, K, Gao, M, Chong, Z, Li, Y, Han, X, Chen, R & Qin, L 2016, Lab on a Chip - Miniaturisation for Chemistry and Biology, vol. 16, no. 24, pp. 4742-4748. https://doi.org/10.1039/c6lc01241h SINGLE-CELL PIPETTE ASSEMBLY COMPRISING SINGLE-CELL PIPETTE HANDLE AND SINGLE-CELL PIPETTE TIP Qin, L & Zhang, K 2016, , Patent No. US2016339422, IPC No. B01L 3/ 02 A I. SINGLE-CELL PIPETTE ASSEMBLY COMPRISING SINGLE-CELL PIPETTE HANDLE AND SINGLE-CELL PIPETTE TIP QIN, LIDONG & ZHANG, KAI 2016, , Patent No. SG11201605894V, IPC No. B01L 3/ 02 A I.