Parquette, Jon - The Ohio State University - Department of Chemistry & Biochemistry

个人简介

Jon R. Parquette received a B.S degree in chemistry from the University of California, Berkeley in 1988, and his Ph.D. in 1994 from Stanford University working with Barry M. Trost. At Stanford, he was an American Chemical Society, Division of Organic Chemistry Fellow. After completing postdoctoral work at Caltech in 1996, working with Peter Dervan as an American Cancer Society Postdoctoral Fellow, he became a faculty member at The Ohio State University. His research is currently supported by a National Science Foundation CAREER AWARD (1999).

研究领域

Our research program revolves around the theme of applied synthetic organic chemistry. We are particularly interested in the design and synthesis of functional macromolecules that fold or self-assemble into well-defined nanostructures because these molecules have tremendous potential to function as enantioselective catalysts, targeted drug delivery agents and electronic materials, among many other applications. Consequently, this work is highly collaborative in nature, involving researchers in diverse fields ranging from electrical engineering to oncology. Students involved in my research program will primarily learn techniques in synthetic organic chemistry; however, a broad appreciation of topics of immediate national (such as energy production and storage) and biomedical interest (anticancer approaches) will be developed. Current areas of interest include: Supramolecular Organocatalysis. Asymmetric Catalysis via Dynamically Chiral Ligands. Self-Assembly of Nanostructures for Optoelectronics. Supramolecular Strategies for Treatment and Imaging of Cancer.

近期论文

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Strategy for the Co-Assembly of Co-Axial Nanotube−Polymer Hybrids Ji, Mingyang; Dawadi, Mahesh B.; LaSalla, Alexandria R.; Sun, Yuan; Modarelli, David A.; Parquette, Jon R.Langmuir. (2017), 33, 9129-9136 Controlling the length of self-assembled nanotubes by sonication followed by polymer wrapping Ji, Mingyang; Danials, Brian; Sheih, Aileen; Modarelli, David A.; Parquette, Jon R. Chem. Commun. (2017), 53, 12806-12809 Oligothiophene compounds inhibit the membrane fusion between H5N1 avian influenza virus and the endosome of host cell Zhu, Zhibo; Yao, Zhili; Shen, Xiantian; Chen, Zhipeng; Liu, Xiangtao; Parquette, Jon R.; Liu, Shuwen Eur. J. Med. Chem. (2017), 130, 185-194. The self-assembly of a camptothecin-lysine nanotube Sun, Yuan; Shieh, Aileen; Kim, Se Hye; King, Samantha; Kim, Anne; Sun, Hui-Lung; Croce, Carlo M.; Parquette, Jon R.Bioorg. Med. Chem. Lett. (2016), 26(12), 2834-2838. Synthetic CO2-fixation enzyme cascades immobilized on self-assembled nanostructures that enhance CO2/O2 selectivity of RubisCO Satagopan Sriram; Tabita F Robert; Sun Yuan; Parquette Jon R Biotechnol. Biofuels (2017), 10, 175. Self-assembly of a 5-fluorouracil-dipeptide hydrogel Sun, Yuan; Kaplan, Jonah A.; Shieh, Aileen; Sun, Hui-Lung; Croce, Carlo M.; Grinstaff, Mark W.; Parquette, Jon R. Chem. Commun. (2016), 52(30), 5254-5257. A self-assembled nanotube for the direct aldol reaction in water Lee Kwang Soo; Parquette Jon R Chem. Commun. (2015), 51(86), 15653-6. A Structural Model for a Self-Assembled Nanotube Provides Insight into Its Exciton Dynamics Gao, Min; Paul, Subhradip; Schwieters, Charles D.; You, Zhi-Qiang; Shao, Hui; Herbert, John M.; Parquette, Jon R.; Jaroniec, Christopher P. J. Phys. Chem. C (2015), 119(24), 13948-13956. Photo-crosslinking of a self-assembled coumarin-dipeptide hydrogel Kim, Se Hye; Sun, Yuan; Kaplan, Jonah A.; Grinstaff, Mark W.; Parquette, Jon R.New. J. Chem. (2015), 39(5), 3225-3228. The self-assembly of anticancer camptothecin-dipeptide nanotubes: a minimalistic and high drug loading approach to increased efficacy Kim Se Hye; Kaplan Jonah A; Sun Yuan; Shieh Aileen; Sun Hui-Lung; Croce Carlo M; Grinstaff Mark W; Parquette Jon R Chemistry. (2015), 21(1), 101-5. 1D self-assembly of terthiophene (3T)-naphthalenediimide (NDI) dyad Kim, Se Hye; Parquette, Jon R. Chem. Lett. (2014), 43(10), 1634-1636. Bimetallic catalysis in the highly enantioselective ring-opening reactions of aziridines Wu, Bin; Gallucci, Judith C.; Parquette, Jon R.; RajanBabu, T. V. Chem. Sci. (2014), 5(3), 1102-1117. Proton-Coupled Self-Assembly of a Porphyrin-Naphthalenediimide Dyad Tu, Siyu; Kim, Se Hye; Joseph, Jojo; Modarelli, David A.; Parquette, Jon R.ChemPhysChem (2013), 14(8), 1609-1617. A model for the controlled assembly of semiconductor peptides Kim Se Hye; Parquette Jon R Nanoscale (2012), 4(22), 6940-7. Intramolecular chiral communication in peptide-dendron hybrids Shao, Hui; Bewick, Nicholas A.; Parquette, Jon R. Org. Biomol. Chem. (2012), 10(12), 2377-2379. Right- and Left-Handed Helices, What is in between? Interconversion of Helical Structures of Alternating Pyridinedicarboxamide/m-(phenylazo)azobenzene Oligomers Tao Peng; Parquette Jon R; Hadad Christopher M J. Chem. Theory. Comput. (2012), 8(12), 5137-49. Aqueous self-assembly of L-lysine-based amphiphiles into 1D n-type nanotubes Shao Hui; Gao Min; Kim Se Hye; Jaroniec Christopher P; Parquette Jon R Chemistry (2011), 17(46), 12882-5. Self-assembly of a donor-acceptor nanotube. A strategy to create bicontinuous arrays Tu Siyu; Kim Se Hye; Joseph Jojo; Modarelli David A; Parquette Jon R J. Am. Chem. Soc. (2011), 133(47), 19125-30. A π-conjugated hydrogel based on an Fmoc-dipeptide naphthalene diimide semiconductor Shao, Hui; Parquette, Jon R. Chem. Commun. (2010), 46(24), 4285-4287. Amphiphilic self-assembly of an n-type nanotube Shao, Hui; Seifert, James; Romano, Natalie C.; Gao, Min; Helmus, Jonathan J.; Jaroniec, Christopher P.; Modarelli, David A.; Parquette, Jon R. Angew. Chem. Int. Edit. (2010), 49(42), 7688-7691, S7688/1-S7688/35.