Zheng, Gang - University Health Network - Princess Margaret Cancer Centre

个人简介

Additional Appointments Senior Scientist, Princess Margaret Cancer Centre Associate Research Director, Princess Margaret Cancer Centre Professor of Medical Biophysics, University of Toronto Professor, Institute of Biomaterials and Biomedical Engineering, University of Toronto Professor, Department of Pharmaceutical Sciences, University of Toronto Full Member, Institute of Medical Science, University of Toronto Scientist (Cross-Appointment), Joint Department of Medical Imaging, Mount Sinai Hospital, University Health Network, and Women’s College Hospital Canada Research Chair in Cancer Nanomedicine, Tier I Associate Editor, Bioconjugate Chemistry Fellow, American Institute of Medical and Biological Engineering (AIMBE) Dr. Gang Zheng is a Senior Scientist and the Associate Research Director at the Princess Margaret Cancer Center, University Health Network. He is also a Tier 1 Canada Research Chair in Cancer Nanomedicine and a Professor of Medical Biophysics, Biomedical Engineering, Pharmaceutical Sciences and Medical Science at the University of Toronto. He obtained his BSc in Chemistry from the Hangzhou University (now Zhejiang University) in 1988, MSc in Organic Chemistry from Hampton University in 1995, and PhD in Medicinal Chemistry from the State University of New York at Buffalo in 1999, followed by a postdoctoral training in photodynamic therapy at the Roswell Park Cancer Institute. He joined the University of Pennsylvania in 2001 as an Assistant Professor of Radiology, rose to the rank of Associate Professor, then moved to Canada in 2006. His research program focuses on cancer nanomedicine, molecular imaging and photodynamic therapy, with emphasis on developing clinically translatable technologies to combat cancer. Dr. Zheng’s most significant contributions are his pioneering work on activatable photosensitizers for photodynamic therapy and his discovery of porphysome nanotechnology that popularized the “one-for-all” nanoparticle design principle along with the more conventional “all-in-one” design. Dr. Zheng is an experienced PI and research team leader, having led a NIH Unconventional Innovations Program (2003-2006), a Canada Foundation for Innovation (CFI) Nanomedicine Fabrication Center (2010-2014), a Canadian Institutes of Health Research (CIHR) Nanomedicine Team Grant (2011-2016), a Terry Fox Research Institute (TFRI) New Frontiers Program Project Grant (2017-2022) and a CIHR Foundation Grant (2017-2024). Dr. Zheng is a Fellow of the American Institute of Medical and Biological Engineering (AMIBE), and an Associate Editor for the Bioconjugate Chemistry.

研究领域

The main interest of the Zheng group is to develop clinically translatable technology platforms to combat cancer. Examples are: Porphysome nanotechnology Lipoprotein-like nanoparticles Photodynamic molecular beacons

近期论文

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A Novel Laser Fiberscope for Simultaneous Imaging and Phototherapy of Peripheral Lung Cancer. (link is external)Chest. 2019 Apr 26;:Kinoshita T, Effat A, Gregor A, Inage T, Ishiwata T, Motooka Y, Ujiie H, Wilson BC, Zheng G, Weersink R, Asamura H, Yasufuku K Evaluation of novel imaging devices for nanoparticle-mediated fluorescence-guided lung tumor therapy. (link is external)Ann Thorac Surg. 2019 Feb 08;:Kinoshita T, Ujiie H, Chen J, Ding L, Chan H, Gregor A, Bernards N, McVeigh PZ, Fujino K, Lee CY, Motooka Y, Inage T, Valic MS, Effat A, Weersink R, Wilson BC, Zheng G, Asamura H, Yasufuku K Stenosing tenosynovitis : Evaluation of percutaneous release with a specially designed needle vs. open surgery. (link is external)Orthopade. 2019 Jan 08;:Xie P, Zhang QH, Zheng GZ, Liu DZ, Miao HG, Zhang WF, Ye JF, Du SX, Li XD Study of the enantioselectivity and recognition mechanism of sulfhydryl-compound-functionalized gold nanochannel membranes. (link is external)Anal Bioanal Chem. 2018 Nov 19;:Huang L, Lin Q, Li Y, Zheng G, Chen Y Advanced photosensitizer activation strategies for smarter photodynamic therapy beacons. (link is external)Angew Chem Int Ed Engl. 2018 Jun 11;:Luby BM, Walsh CD, Zheng G Specific and Direct Amplified Detection of MicroRNA with MicroRNA:Argonaute-2 Cleavage (miRACle) Beacons. (link is external)Angew Chem Int Ed Engl. 2017 Oct 23;56(44):13704-13708Luby BM, Zheng G Activatable fluorescence: From small molecule to nanoparticle. (link is external)Adv Drug Deliv Rev. 2017 04;113:97-121Luby BM, Charron DM, MacLaughlin CM, Zheng G PorphyrinHDL: A Novel Photosensitizing Nanoparticle for Lung Cancer Therapy. (link is external)Ann Thorac Surg. 2018 Oct 11;:Ujiie H, Ding L, Fan R, Kato T, Lee D, Fujino K, Kinoshita T, Lee CY, Waddell TK, Keshavjee S, Wilson BC, Zheng G, Chen J, Yasufuku K Preclinical investigation of folate receptor-targeted nanoparticles for photodynamic therapy of malignant pleural mesothelioma. (link is external)Int J Oncol. 2018 Nov;53(5):2034-2046 Kato T, Jin CS, Lee D, Ujiie H, Fujino K, Hu HP, Wada H, Wu L, Chen J, Weersink RA, Kanno H, Hatanaka Y, Hatanaka KC, Kaga K, Matsui Y, Matsuno Y, De Perrot M, Wilson BC, Zheng G, Yasufuku K GM1-Modified Lipoprotein-like Nanoparticle: Multifunctional Nanoplatform for the Combination Therapy of Alzheimer's Disease. (link is external)ACS Nano. 2015 Nov 24;9(11):10801-16Huang M, Hu M, Song Q, Song H, Huang J, Gu X, Wang X, Chen J, Kang T, Feng X, Jiang D, Zheng G, Chen H, Gao X Comparison of continuous compression with regular ventilations versus 30:2 compressions-ventilations strategy during mechanical cardiopulmonary resuscitation in a porcine model of cardiac arrest. (link is external)J Thorac Dis. 2017 Sep;9(9):3232-3238 Yang Z, Liu Q, Zheng G, Liu Z, Jiang L, Lin Q, Chen R, Tang W Effect of removing Kupffer cells on nanoparticle tumor delivery. (link is external)Proc Natl Acad Sci U S A. 2017 Dec 05;:Tavares AJ, Poon W, Zhang YN, Dai Q, Besla R, Ding D, Ouyang B, Li A, Chen J, Zheng G, Robbins C, Chan WCW Nanoparticle targeted folate receptor 1-enhanced photodynamic therapy for lung cancer. (link is external)Lung Cancer. 2017 Nov;113:59-68 Kato T, Jin CS, Ujiie H, Lee D, Fujino K, Wada H, Hu HP, Weersink RA, Chen J, Kaji M, Kaga K, Matsui Y, Wilson BC, Zheng G, Yasufuku K Personalized siRNA-Nanoparticle Systemic Therapy using Metastatic Lymph Node Specimens Obtained with EBUS-TBNA in Lung Cancer. (link is external)Mol Cancer Res. 2017 Oct 09;:Kato T, Lee D, Huang H, Cruz W, Ujiie H, Fujino K, Wada H, Patel P, Hu HP, Hirohashi K, Nakajima T, Sato M, Kaji M, Kaga K, Matsui Y, Chen J, Zheng G, Yasufuku K Electric field control of magnetization direction across the antiferromagnetic to ferromagnetic transition. (link is external)Sci Rep. 2017 Jul 14;7(1):5366 Zheng G, Ke SH, Miao M, Kim J, Ramesh R, Kioussis N Can photoacoustic imaging quantify surface-localized J-aggregating nanoparticles? (link is external)J Biomed Opt. 2017 Jul 01;22(7):76008 Lim L, Mastragostino R, Ng K, Zheng G, Wilson BC The role of the Chaperonin containing t-complex polypeptide 1, subunit 8 (CCT8) in B-cell non-Hodgkin's lymphoma. (link is external)Leuk Res. 2016 Jun;45:59-67 Yin H, Miao X, Wu Y, Wei Y, Zong G, Yang S, Chen X, Zheng G, Zhu X, Guo Y, Li C, Chen Y, Wang Y, He S Delayed administration of the GLP-1 receptor agonist liraglutide improves metabolic and functional recovery after cerebral ischemia in rats. (link is external)Neurosci Lett. 2017 Feb 22;641:1-7 Dong W, Miao Y, Chen A, Cheng M, Ye X, Song F, Zheng G Porphysome nanoparticles for enhanced photothermal therapy in a patient-derived orthotopic pancreas xenograft cancer model: a pilot study. (link is external)J Biomed Opt. 2016 Aug 01;21(8):84002 MacLaughlin CM, Ding L, Jin C, Cao P, Siddiqui I, Hwang DM, Chen J, Wilson BC, Zheng G, Hedley DW An Integrated Nanotechnology-Enabled Transbronchial Image-Guided Intervention Strategy for Peripheral Lung Cancer. (link is external) Cancer Res. 2016 Oct 01;76(19):5870-5880 Jin CS, Wada H, Anayama T, McVeigh PZ, Hu HP, Hirohashi K, Nakajima T, Kato T, Keshavjee S, Hwang D, Wilson BC, Zheng G, Yasufuku K