Santos, Hélder A. - University of Helsinki - Division of Pharmaceutical Chemistry and Technology

个人简介

Dr. Hélder A. Santos (https://www.helsinki.fi/en/researchgroups/nanomedicines-and-biomedical-engineering) is a physical chemist specialized in electrochemistry, biological mimetic models and soft interfaces. In 2003, he obtained his MSc in Chemistry from the Department of Chemistry, University of Porto (Portugal). In 2007, he obtained his DSc in Chem. Eng. from the Laboratory of Physical Chemistry and Electrochemistry, Helsinki University of Technology (Finland, now named Aalto University). In 2007, Dr. Santos joined the University of Helsinki, Division of Pharmaceutical Technology, as a Postdoctoral Fellow. In 2009, he was appointed Academy of Finland Postdoctoral Research Fellow. Currently, he is a Full Professor in Biomedical Engineering and Head of Department of Biomedical Engineering, The University Medical Center Groningen/University of Groningen, The Netherlands. Former Full Prof. in Pharmaceutical Nanotechnology, at the University of Helsinki, Finland. Also, currently he is a Group Leader/Research Director and the Head of the Nanomedicines and Biomedical Engineering Group, Faculty of Pharmacy, University of Helsinki. He was also the Head of the Division of Pharmaceutical Chemistry and Technology, the Head of the Research Unit of Pharmaceutical Nanotechnology and Chemical Microsystems (NAMI), and former Head of the Preclinical Drug Formulation and Analysis Group. He is also the Director of the Doctoral Programme in Drug Research (2018-2021) and the Director of the FinPharmaNet (2020-2021). In 2013, Dr. Santos received the ERC starting grant for 2013-2017 worth of 1.5 M€ and an ERC PoC in 2019-2020.

研究领域

My current research interest is the developement and applications of biomaterials for controlled drug delivery, diagnostics and cancer therapy, including inorganic mesoporous silica/silicon particulate systems, liposomes, solid lipid nanoparticles.

近期论文

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Acid-labile chemical bonds-based nanoparticles for endosome escape and intracellular delivery Cheng, R., Wang, S. & Santos, H. A., 2023, In: Biomedical technology. 3, p. 52-58 7 p. Cancer Models on Chip: Paving the Way to Large-Scale Trial Applications Gil, J. F., Moura, C. S., Silverio, V., Goncalves, G. & Santos, H. A., 8 Jul 2023, In: Advanced Materials. 26 p. Controlled Interfacial Polymer Self-Assembly Coordinates Ultrahigh Drug Loading and Zero-Order Release in Particles Prepared under Continuous Flow Zhang, P., Liu, Y., Feng, G., Li, C., Zhou, J., Du, C., Bai, Y., Hu, S., Huang, T., Wang, G., Quan, P., Hirvonen, J., Fan, J., Santos, H. A. & Liu, D., 2023, In: Advanced Materials. Development of a time-dependent oral colon delivery system of anaerobic Odoribacter splanchnicus for bacteriotherapy Bosch, B., Moutaharrik, S., Gazzaniga, A., Hiippala, K., Santos, H. A., Maroni, A. & Satokari, R., Sep 2023, In: European Journal of Pharmaceutics and Biopharmaceutics. 190, p. 73-80 8 p. Development of fast dissolving polymer-based microneedles for delivery of an antigenic melanoma cell membrane Lobita, M. C., El-Sayed, N., Pinto, J. F. & Santos, H. A., 25 Jul 2023, In: International Journal of Pharmaceutics. 642, 12 p., 123143. Development of siRNA and Budesonide Dual-Loaded Hybrid Lipid-Polymer Nanoparticles by Microfluidics Technology as a Platform for Dual Drug Delivery to Macrophages: An In Vitro Mechanistic Study Cerda, S. L., Fontana, F., Wang, S., Correia, A., Molinaro, G., Tello, R. P., Hirvonen, J., Celia, C., Barreto, G. & Santos, H. A., Aug 2023, In: Advanced Therapeutics. 6, 8, 16 p., 2300048. Double-Layered Polyvinylpyrrolidone-Poly(methyl vinyl ether-alt-maleic acid)-Based Microneedles to Deliver Meloxicam: An In Vitro, In Vivo, and Short-Term Stability Evaluation Study D'Amico, C., Fontana, F., El-Sayed, N., Elbadri, K., Correia, A., Rahikkala, A., Saarinen, J., Shahbazi, M-A. & Santos, H. A., Aug 2023, In: Advanced Therapeutics. 6, 8, 10 p. Enhancing Apoptosome Assembly via Mito-Biomimetic Lipid Nanocarrier for Cancer Therapy Han, H., Chen, J., Li, J., Correia, A., Bartolo, R., Shahbazi, M-A., Teesalu, T., Wang, S., Cui, W. & Santos, H. A., 12 Jul 2023, In: Advanced Functional Materials. 11 p. Evaluation of cell membrane-derived nanoparticles as therapeutic carriers for pancreatic ductal adenocarcinoma using an in vitro tumour stroma model Tapeinos, C., Torrieri, G., Wang, S., Martins, J. P. & Santos, H. A., Oct 2023, In: Journal of Controlled Release. 362, p. 225-242 18 p. Fabrication of hydrogel microspheres via microfluidics using inverse electron demand Diels-Alder click chemistry-based tetrazine-norbornene for drug delivery and cell encapsulation applications Tello, R. P., Wang, S., Fontana, F., Correia, A., Molinaro, G., Cerda, S. L., Hietala, S., Hirvonen, J., Barreto, G. & Santos, H. A., 12 Jul 2023, In: Biomaterials Science. 11, 14, p. 4972-4984 13 p. Injectable Nanocomposite Hydrogels of Gelatin-Hyaluronic Acid Reinforced with Hybrid Lysozyme Nanofibrils-Gold Nanoparticles for the Regeneration of Damaged Myocardium Carvalho, T., Bartolo, R., Pedro, S. N., Valente, B. F. A., Pinto, R. J. B., Vilela, C., Shahbazi, M-A., Santos, H. A. & Freire, C. S. R., 18 May 2023, In: ACS Applied Materials & Interfaces. 15, 21, p. 25860-25872 13 p. Introduction to the RSC Advances themed collection on Nanomaterials in drug delivery Santos, H. A. & Savina, I. N., 6 Jan 2023, In: RSC Advances. 13, 3, p. 1933-1934 2 p. In Vitro Characterization and Real-Time Label-Free Assessment of the Interaction of Chitosan-Coated Niosomes with Intestinal Cellular Monolayers Scurti, E., Martins, J. P., Celia, C., Palumbo, P., Lombardi, F., Iannotta, D., Di Marzio, L., Santos, H. A. & Viitala, T., 2 Jun 2023, In: Langmuir. 39, 23, p. 8255-8266 12 p. In Vitro Study of the Anti-inflammatory and Antifibrotic Activity of Tannic Acid-Coated Curcumin-Loaded Nanoparticles in Human Tenocytes Molinaro, G., Fontana, F., Pareja Tello, R., Wang, S., López Cerdá, S., Torrieri, G., Rebelo Correia, A. M., Waris, E. M., Hirvonen, J. T., Barreto, G. & Santos, H. A., 2 May 2023, In: ACS Applied Materials & Interfaces. 15, 19, p. 23012-23023 12 p. Macrophage Hitchhiking Nanoparticles for the Treatment of Myocardial Infarction: An In Vitro and In Vivo Study Torrieri, G., Iqbal, I., Fontana, F., Talman, V., Liljenback, H., Putri, A., Nammas, W., Rajander, J., Guo-Li, X., Low, P. S. S., Teesalu, T., Roivainen, A., Hirvonen, J., Ruskoaho, H., Balasubramanian, V., Saraste, A. & Santos, H. A., Aug 2023, In: Advanced Functional Materials. 33, 34, 16 p. Microfluidic-Assisted Production of Gastro-Resistant Active-Targeted Diatomite Nanoparticles for the Local Release of Galunisertib in Metastatic Colorectal Cancer Cells Tramontano, C., Martins, J. P., De Stefano, L., Kemell, M., Correia, A., Terracciano, M., Borbone, N., Rea, I. & Santos, H. A., Jan 2023, In: Advanced Healthcare Materials. 12, 6, 17 p. Multifunctional nanostructures: Intelligent design to overcome biological barriers Azizi, M., Jahanban-Esfahlan, R., Samadian, H., Hamidi, M., Seidi, K., Dolatshahi-Pirouz, A., Yazdi, A. A., Shavandi, A., Laurent, S., Hagh, M. B. O., Kasaiyan, N., Santos, H. A. & Shahbazi, M-A., Jun 2023, In: Materials today bio. 20, 28 p., 100672. Mycophenolic Acid-loaded Naïve Macrophage-derived Extracellular Vesicles Rescue Cardiac Myoblast after Inflammatory Injury Gao, H., Wang, S., Liu, Z., Hirvonen, J. & Santos, H. A., 2023, In: ACS Applied Bio Materials. Nanoparticles-based phototherapy systems for cancer treatment: Current status and clinical potential Li, J., Wang, S., Fontana, F., Tapeinos, C., Shahbazi, M. -A., Han, H. & Santos, H. A., May 2023, In: Bioactive Materials. 23, p. 471-507 37 p. A pH-Responsive Cluster Metal-Organic Framework Nanoparticle for Enhanced Tumor Accumulation and Antitumor Effect Cheng, R., Jiang, L., Gao, H., Liu, Z., Makila, E., Wang, S., Saiding, Q., Xiang, L., Tang, X., Shi, M., Liu, J., Pang, L., Salonen, J., Hirvonen, J., Zhang, H., Cui, W., Shen, B. & Santos, H. A., 13 Sep 2022, (E-pub ahead of print) In: Advanced Materials. 13 p., 2203915. Artificial Intelligence Deep Exploration of Influential Parameters on Physicochemical Properties of Curcumin-Loaded Electrospun Nanofibers Khedri, M., Beheshtizadeh, N., Rostami, M., Sufali, A., Rezvantalab, S., Dahri, M., Maleki, R., Santos, H. A. & Shahbazi, M-A., Jun 2022, In: Advanced nanobiomed research. 2, 6, 10 p., 2100143. Autologous Skin Fibroblast-Based PLGA Nanoparticles for Treating Multiorgan Fibrosis Long, Q., Liu, Z., Shao, Q., Shi, H., Huang, S., Jiang, C., Qian, B., Zhong, Y., He, X., Xiang, X., Yang, Y., Li, B., Yan, X., Zhao, Q., Wei, X., Santos, H. A. & Ye, X., Jul 2022, In: Advanced Science. 9, 21, 14 p., 2200856. Biomimetic platelet membrane-coated nanoparticles for targeted therapy Han, H., Bartolo, R., Li, J., Shahbazi, M-A. & Santos, H. A., Mar 2022, In: European Journal of Pharmaceutics and Biopharmaceutics. 172, p. 1-15 15 p. Development of Surface Chemical Strategies for Synthesizing Redox-Responsive Diatomite Nanoparticles as a Green Platform for On-Demand Intracellular Release of an Antisense Peptide Nucleic Acid Anticancer Agent Terracciano, M., Fontana, F., Falanga, A. P., D'Errico, S., Torrieri, G., Greco, F., Tramontano, C., Rea, I., Piccialli, G., De Stefano, L., Oliviero, G., Santos, H. A. & Borbone, N., Oct 2022, In: Small. 18, 41, 14 p., 2204732. Emerging Theranostic Nanomaterials in Diabetes and Its Complications Liu, Y., Zeng, S., Ji, W., Yao, H., Lin, L., Cui, H., Santos, H. A. & Pan, G., Jan 2022, In: Advanced Science. 9, 3, 54 p., 2102466. Engineered neutrophil-derived exosome-like vesicles for targeted cancer therapy Zhang, J., Ji, C., Zhang, H., Shi, H., Mao, F., Qian, H., Xu, W., Wang, D., Pan, J., Fang, X., Santos, H. A. & Zhang, X., Jan 2022, In: Science Advances. 8, 2, 13 p., 8207. Folic acid-mesoporous silicon nanoparticles enhance the anticancer activity of the p73-activating small molecule LEM2 Gomes, A. S., Correia, A., Rahikkala, A., Mäkilä, E., Pinto, M. M., Sousa, E., Salonen, J., Saraiva, L. & Santos, H. A., 25 Aug 2022, In: International Journal of Pharmaceutics. 624, 10 p., 121959. Gelatin-Lysozyme Nanofibrils Electrospun Patches with Improved Mechanical, Antioxidant and Bioresorbability Properties for Myocardial Regeneration Applications Carvalho, T., Ezazi, N. Z., Correia, A., Vilela, C., Santos, H. A. & Freire, C. S. R., May 2022, In: Advanced Functional Materials. 32, 21, 12 p., 2113390. High drug-loaded microspheres enabled by controlled in-droplet precipitation promote functional recovery after spinal cord injury Li, W., Chen, J., Zhao, S., Huang, T., Ying, H., Trujillo, C., Molinaro, G., Zhou, Z., Jiang, T., Liu, W., Li, L., Bai, Y., Quan, P., Ding, Y., Hirvonen, J., Yin, G., Santos, H. A., Fan, J. & Liu, D., 10 Mar 2022, In: Nature Communications. 13, 1, 16 p., 1262. Inhaled hydrogel-based microspheres for management of COVID-19: A new sweeper biological platform Cheng, R. & Santos, H. A., 6 Apr 2022, In: Matter. 5, 4, p. 1065-1067 3 p. In vitro Evaluation of the Therapeutic Effects of Dual-Drug Loaded Spermine-Acetalated Dextran Nanoparticles Coated with Tannic Acid for Cardiac Applications Torrieri, G., Almeida Ferreira, M., Shahbazi, M-A., Talman, V., Karhu, T., Pohjolainen, L., Carvalho, C., Pinto, J. F., Hirvonen, J., Ruskoaho, H., Balasubramanian, V. & Santos, H. A., 26 Jan 2022, In: Advanced Functional Materials. 32, 5, 16 p., 2109032. Microfluidic-Assisted Production of Gastro-Resistant Active-Targeted Diatomite Nanoparticles for the Local Release of Galunisertib in Metastatic Colorectal Cancer Cells Tramontano, C., Martins, J. P., De Stefano, L., Kemell, M., Correia, A., Terracciano, M., Borbone, N., Rea, I. & Santos, H. A., 11 Dec 2022, In: Advanced Healthcare Materials. 17 p. Microfluidic preparation and optimization of sorafenib-loaded poly(ethylene glycol-block-caprolactone) nanoparticles for cancer therapy applications Känkänen, V., Fernandes, M., Liu, Z., Seitsonen, J., Hirvonen, S-P., Ruokolainen, J., Pinto, J. F., Hirvonen, J., Balasubramanian, V. & Santos, H. A., 24 Nov 2022, In: Journal of Colloid and Interface Science. 2023, 633 Microfluidics Fabrication of Micrometer-Sized Hydrogels with Precisely Controlled Geometries for Biomedical Applications Wei, Z., Wang, S., Hirvonen, J., Santos, H. A. & Li, W., 17 Aug 2022, In: Advanced Healthcare Materials. 11, 16, 23 p., 2200846. Multifunctional Biomimetic Nanovaccines Based on Photothermal and Weak-Immunostimulatory Nanoparticulate Cores for the Immunotherapy of Solid Tumors Li, J., Huang, D., Cheng, R., Figueiredo, P., Fontana, F., Correia, A., Wang, S., Liu, Z., Kemell, M., Torrieri, G., Makila, E. M., Salonen, J. J., Hirvonen, J., Gao, Y., Li, J., Luo, Z., Santos, H. A. & Xia, B., Mar 2022, In: Advanced Materials. 34, 9, 12 p., 2108012. Mussel-Inspired and Bioclickable Peptide Engineered Surface to Combat Thrombosis and Infection Mou, X., Zhang, H., Qiu, H., Zhang, W., Wang, Y., Xiong, K., Huang, N., Santos, H. A. & Yang, Z., 14 Apr 2022, In: Research. 2022, 14 p., 9780879. Neonatal Fc receptor-targeted lignin-encapsulated porous silicon nanoparticles for enhanced cellular interactions and insulin permeation across the intestinal epithelium Martins, J. P., Figueiredo, P., Wang, S., Espo, E., Celi, E., Martins, B., Kemell, M., Moslova, K., Mäkilä, E., Salonen, J., Kostiainen, M., Celia, C., Cerullo, V., Viitala, T., Sarmento, B., Hirvonen, J. & Santos, H. A., Mar 2022, In: Bioactive Materials. 9, p. 299-315 17 p. Progress in Stimuli-Responsive Biomaterials for Treating Cardiovascular and Cerebrovascular Diseases Tapeinos, C., Gao, H., Bauleth-Ramos, T. & Santos, H. A., Sep 2022, In: Small. 18, 36, 36 p., 2200291.