李宜明 - 合肥工业大学 - 食品与生物工程学院

个人简介

2017.12-至今合肥工业大学食品与生物工程学院，教授 2012.7-2017.12合肥工业大学生物与医学工程学院，副研究员 2010.7-2012.7清华大学化学系/清华大学-北京大学生命科学联合中心，博士后 2009.9-2011.2北京大学化学生物学系，访问学者 2010.7中国科学技术大学化学系，获博士学位

研究领域

课题组主要研究领域为蛋白质化学生物学及食品化学，具体方向如下： 1. 蛋白质酶促半合成新方法体系的开拓及应用 2. 泛素家族蛋白质化学探针的合成、蛋白质组学及生物化学应用 3. 药物、食品中活性多肽的结构改性及生物学应用

近期论文

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Zheng, Q. Y.; Wang, T.; Chu, G. C.; Zuo, C.; Zhao, R.; Zhang, W.; Deng, H.; Shi, J.; Pan, M.*; Li, Y.-M.*; Liu, L.* Isopeptide-N-ethylated deubiquitylase-resistant ubiquitin probesmade through an E1-catalyzed chemoenzymatic strategy, Angew. Chem. Int. Ed. 2020, DOI: 10.1002/anie.202002974. Chu, G. C.;Pan, M.; Li, J.; Liu, S.; Zuo, C.; Tong, Z.-B.; Bai, J.-S.; Gong, Q.; Ai, H.; Fan, J.; Meng, X.; Huang, Y.-C.; Shi, J.; Deng, H.; Tian*, C.; Li, Y.-M.*; Liu, L.* Cysteine-Aminoethylation Assisted Chemical Ubiquitination of Recombinant Histones, J. Am. Chem. Soc., 2019, 141, 3654-3663. Li, Y. T.; Yi, C.; Chen, C. C.; Lan, H.; Pan, M.; Zhang, S. J.; Huang, Y. C.; Guan, C. J.;Li, Y. M.*; Yu, L.*; Liu, L.* A semisynthetic Atg3 reveals that acetylationpromotes Atg3 membrane binding and Atg8lipidation. Nature Commun.2017, 8, 14846. Wang, Y.; Chen, C. C.; Meng, X.; Fan, J.; Pan, M.; Chen, J; Deng, H.; Shi, J.*; Liu, L.; Li, Y.-M.* Chemical Synthesis of diSUMO Photoaffinity Probes for the Identification of PolySUMO-Chain Specific Interacting Proteins. CCS Chem. 2020, DOI: 10.31635/ccschem.020.202000282. Li, Y. M.;Li, Y. T.; Pan, M.; Kong, X. Q.; Huang, Y. C.; Hong, Z. Y.; Liu, L.* Irreversible Site-Specific Hydrazinolysis of Proteins by Use of Sortase. Angew. Chem. Int. Ed. 2014,53, 2198-2202. Zhao, R.; Shi, P.; Chen, J. Y.; Sun, S. S.; Chen, J. N.; Cui. J. B.; Wu, F. M.; Fang, G. M.; Tian, C. L; Shi, J.;* Bierer, D.; Liu, L.; Li, Y. M.* Chemical synthesis and biological activity of peptides incorporating an ether bridge as a surrogate for a disulfide bond. Chemical Science 2020, DOI: 10.1039/D0SC02374D. Tang, X. L.; Pan, M.; Zheng, Y.; Gao, S.; Liang, L. J., Li, Y. M.* Sortase-mediated chemical protein synthesisreveals the bidentate binding of bisphosphorylatedp62 with K63 diubiquitin. Chemical Science2017, 8, 6881-6887. Huang, Y. C.‡; Li, Y. M.‡;Chen,Y.; Pan, M.; Li, Y. T.; Yu, L.; Guo, Q. X.; Liu, L.* Synthesis of Autophagosomal Marker Protein LC3-II under Detergent-Free Conditions. Angew. Chem. Int. Ed. 2013,52, 4858-4862. (‡共同第一作者) Li, Y. M.;Yang, M. Y.; Huang, Y. C.; Song, X. D.; Liu, L.*; Chen, P. R.* Genetically encoded alkenyl-pyrrolysine analogues for thiol-ene reaction mediated site-specific protein labeling.Chemical Science2012, 3, 2766-2770. Chen, C.-C.; Gao, S.; Ai, H.-S.; Qu, Q.; Tian, C.; Li, Y.-M.*Racemic X-ray structure of L-type calcium channel antagonist Calciseptine prepared by total chemical synthesis,Science China: Chem.2018, 61, 702-707.