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Zhao, Panxia#; Kong, Fanhui#; Jiang, Yiping#; Qin, Xiangquan; Tian, Xiaoxia; Cong, Zhiqi*. Enabling Peroxygenase Activity in Cytochrome P450 Monooxygenases by Engineering Hydrogen Peroxide Tunnels. J. Am. Chem. Soc. 2023. https://doi.org/10.1021/jacs.3c00195.
Wang, Xiling#; Lin, Xiaodan#; Jiang, Yiping#; Qin, Xiangquan#; Ma, Nana; Yao, Fuquan; Dong, Sheng; Liu, Chuanfei; Feng, Yingang; Jin, Longyi; Xian, Mo; Cong, Zhiqi*. Engineering Cytochrome P450BM3 Enzymes for Direct Nitration of Unsaturated Hydrocarbons. Angew. Chem. Int. Ed Engl. 2023, e202217678.
Chen, Jie#; Dong, Sheng#; Fang, Wenhan#; Jiang, Yiping; Chen, Zhifeng; Qin, Xiangquan; Wang, Cong; Zhou, Haifeng; Jin, Longyi; Feng, Yingang*; Wang, Binju*; Cong, Zhiqi*. Regiodivergent and Enantioselective Hydroxylation of C-H Bonds by Synergistic Use of Protein Engineering and Exogenous Dual-Functional Small Molecules. Angew. Chem. Int. Ed Engl. 2023, 62, e202215088.
Kong, Fanhui; Chen, Jie; Qin, Xiangquan; Liu, Chuangfei; Jiang, Yiping; Ma, Li; Xu, Huifang*; Li, Shengying*; Cong, Zhiqi*. Evolving a P450BM3 Peroxygenase for the Production of Indigoid Dyes from Indoles. ChemCatChem. 2022, 14 (24). https://doi.org/10.1002/cctc.202201151.
Di, Siyu; Fan, Shengxian; Jiang, Fengjie; Cong, Zhiqi*. A Unique P450 Peroxygenase System Facilitated by a Dual-Functional Small Molecule: Concept, Application, and Perspective. Antioxidants (Basel) 2022, 11, 529.
Qin, Xiangquan#; Jiang, Yiping#; Chen, Jie; Yao, Fuquan; Zhao, Panxia; Jin Longyi; Cong, Zhiqi*. Co-Crystal Structure-Guided Optimization of Dual-Functional Small Molecules for Improving the Peroxygenase Activity of Cytochrome P450BM3. Int. J. Mol. Sci. 2022, 23, 7901.
Mahor, Durga; Cong, Zhiqi; J. Weissenborn, Martin; Hollmann, Frank; Zhang, Wuyuan*.Valorization of Small Alkanes by Biocatalytic Oxyfunctionalization. ChemSusChem 2021, 14, 1-12.
Zhang, Xuan#; Jiang, Yiping#; Chen, Qianqian#; Dong, Sheng; Feng, Yingang; Cong, Zhiqi*; Shaik, Sason; Wang, Binju*. H-Bonding Networks Dictate the Molecular Mechanism of H2O2 Activation by P450. ACS Catal. 2021, 11, 8774-8785.
Ma, Nana#; Fang, Wenhan#; Liu, Chuanfei; Qin, Xiangquan; Wang, Xiling; Jin, Longyi; Wang, Binju*; Cong, Zhiqi*. Switching an Artificial P450 Peroxygenase into Peroxidase via Mechanism-Guided Protein Engineering. ACS Catal. 2021, 11, 8449-8455. (Featured in: Kim H, Faculty Opinions 2021, doi: 10.3410/f.740620167.793587804)
Zhao, Panxia#; Chen, Jie#; Ma, Nana; Chen, Jingfei; Qin, Xiangquan; Liu, Chuanfei Yao, Fuquan; Yao, Lishan; Jin, Longyi and Cong, Zhiqi*. Enabling Highly (R)-Enantioselective Epoxidation of Styrene by Engineering Unique Non-Natural P450 Peroxygenases. Chem. Sci. 2021, 12, 6307-6314. (Back Cover; Featured in: “Hot off the Press” in Nat. Prod. Rep. 2021, 38, 1053)
Jiang, Yihui#; Wang, Chunlan#; Ma, Nana; Chen, Jie; Liu, Chuanfei; Wang, Fang; Xu, Jiakun*; Cong, Zhiqi*. Regioselective aromatic: O-demethylation with an artificial P450BM3 peroxygenase system, Catalysis Science & Technology 2020, 10(5), 1219-1223. (Inside Front Cover)
Chen, Jie; Kong,Fanhui; Ma, Nana; Zhao, Panxia; Liu, Chuanfei; Wang, Xiling; Cong, Zhiqi*. Peroxide-Driven Hydroxylation of Small Alkanes Catalyzed by an Artificial P450BM3 Peroxygenase System. ACS Catal. 2019, 9, 7350-7355.
Xu, Jiakun#; Wang, Chunlan#; Cong, Zhiqi*. Strategies for Substrate-Regulated P450 Catalysis: From Substrate Engineering to Co-catalysis. Chem. Eur. J. 2019, 9, 25, 6853–6863.(Invited Concept; Frontispiece; Featured in: Review Showcase)
Ariyasu S.; Kodama Y.; Kasai C.; Cong Z.; Stanfield J.K.; Aiba Y.; Watanabe Y.; Shoji O.*. Development of a High-Pressure Reactor Based on Liquid-Flow Pressurisation to Facilitate Enzymatic Hydroxylation of Gaseous Alkanes, ChemCatChem 2019, 11(19), 4709-4714.
Ma, Nana#; Chen, Zhifeng#; Chen, Jie#; Chen, Jingfei; Wang, Cong; Zhou, Haifeng;Yao, Lishan; Shoji, Osami; Watanabe, Yoshihito; Cong, Zhiqi*. Dual-Functional Small Molecules for Generating an Efficient Cytochrome P450BM3 Peroxygenase. Angew. Chem. Int. Ed. 2018, 57, 7628-7633.(Very Important Paper; Frontispiece; Featured in: ChemistryViews, Link: https://www. chemistryviews. org/details/ezine/11001788/H2O2Dependent_Cytochrome_System.html)
Chen, Zhifeng; Chen, Jie; Ma, Nana; Zhou, Haifeng*; Cong, Zhiqi*. Selective hydroxylation of naphthalene using the H2O2-dependent engineered P450BM3driven by dual-functional small molecules, Journal of Porphyrins and Phthalocyanines 2018, 22(9-10), 831-836.
Shoji, Osami; Yanagisawa, Sota; Stanfield, Joshua Kyle; Suzuki, Kazuto;Cong, Zhiqi; Sugimoto, Hiroshi; Shiro, Yoshitsugu; Watanabe, Yoshihito; *Direct Hydroxylation of Benzene to Phenol by Cytochrome P450BM3 Triggered by Amino Acid Derivatives, Angew. Chem. Int. Ed. 2017, 56(35),10324-10329.
Cong, Zhiqi; Shoji, Osami*; Kasai, Chie; Kawakami, Norifumi; Sugimoto, Hiroshi; Shiro, Yoshitsugu; Watanabe, Yoshihito*. Activation of Wild-type Cytochrome P450BM3by the Next Generation Decoy Molecules: Enhanced Hydroxylation of Gaseous Alkanesand Crystallographic Evidence. ACS Catal. 2015, 5, 150-156.
Kawakami, Norifumi; Cong, Zhiqi; Shoji, Osami; Watanabe, Yoshihito*. Highly efficient hydroxylation of gaseous alkanes at reduced temperature catalyzed by cytochrome P450BM3 assisted by decoy molecules, Journal of Porphyrins and Phthalocyanines 2015, 19(1-3), 329-334.
Cong, Zhiqi; Kinemuchi, Haruki; Kurahashi, Takuya; Fujii, Hiroshi*; Factors Affecting Hydrogen-Tunneling Contribution in Hydroxylation ReactionsPromoted by Oxoiron(IV) Porphyrin pi-Cation Radical Complexes. Inorganic Chemistry 2014, 53(19), 10632-10641.
Cong, Zhiqi Sachiko, Yanagisawa; Kurahashi, Takuya; Takashi, Ogura; Satoru, Nakashima; Fujii, Hiroshi. Synthesis, Charaterizationand Reactivity of Hypochloritoiron(III) Porphyrin Complexes. J. Am. Chem. Soc. 2012, 134, 20617-20620.
Cong, Zhiqi; Kurahashi, Takuya; Fujii, Hiroshi. Formation of Iron(III) meso-Chloro- Isoporphyrinas a Reactive Chlorinating Agent from Oxo-iron(IV) Porphyrin π-Cation Radical. J. Am. Chem. Soc. 2012, 134, 4469-4472.
Cong, Zhiqi; Kurahashi, Takuya; Fujii, Hiroshi. Oxidation of Chloride Ion and Subsequent Chlorination of Organic Compounds by Oxoiron(IV) Porphyrin π-CationRadical Complexes. Angew. Chem. Int. Ed. 2011, 50, 9935-9939.
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