个人简介

Education B.S., 1990, Mankato State University Ph.D., 1994, Iowa State University Postdoctoral, 1995-98, University of Minnesota

研究领域

Inorganic Chemistry

The Berreau laboratory is interested in the role that metal ions play in human health, the environment, and catalysis. Our research is directed at understanding metal-promoted reactions that involve naturally occurring small organic molecules. The goal is to determine the fundamental chemical principles that control such reactions, so that this knowledge can be used to design new compounds that benefit human life. Outlined below are areas of current interest: 1) CO-releasing molecules Carbon monoxide is generally thought of a toxic small molecule. However, recent studies indicate that a low concentration, CO is an important signaling molecule in humans and is known to dilate blood vessels and have anti-inflammatory effects. Based on these properties, an area of emerging research is the development of CO-releasing molecules for the controlled delivery of a specific amount of CO. We are contributing to this area through studies of the photoinduced CO-release reactivity of flavonols. 2) Aliphatic carbon-carbon bond cleavage reactivity 3) Zinc-promoted catalysis in biological systems; relationships to therapeutic targets and metal ion toxicity Metal ions play important roles in catalysis in biological systems, with one of the most abundant metal ions being Zn(II). By studying chemical reactions of relevance to those catalyzed by zinc enzymes, our goal is to provide detailed chemical insight that may assist in the development of new therapeutics and contribute toward understanding metal ion toxicity (upon replacement of Zn(II)).

近期论文

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L. M. Berreau, “Zinc in Biology”, In Comprehensive Inorganic Chemistry II, J. Reedijk and K. Poeppelmeier, Eds., Elsevier, 2013, pp. 179-205. E. S. Elton, T. Zhang, R. Prabhakar, A. M. Arif, L. M. Berreau, “Pb(II)-Promoted Amide Cleavage: Mechanistic Comparison to a Zn(II) Analogue,” Inorg. Chem. 2013, 52, 11480-11492. K. Grubel, S. L. Saraf, S. N. Anderson, Brynna J. Laughlin, R. C. Smith, A. M. Arif, L. M. Berreau, “Synthesis, Characterization, and Photoinduced CO-release Reactivity of a Pb(II) Flavonolate Complex; Comparisons to Group 12 Analogs,” Inorg. Chim. Acta 2013, 407, 91-97. C. J. Allpress, L. M. Berreau, “Oxidative Aliphatic Carbon-carbon Bond Cleavage Reactions,” Coord. Chem. Rev. 2013, 257, 3005-3009. C. J. Allpress, K. Grubel, E. Szajna-Fuller, A. M. Arif, L.M. Berreau, “Regioselective Aliphatic Carbon-carbon Bond Cleavage by a Model System of Relevance to Iron-containing Acireductone Dioxygenase (Fe-ARD’),” J. Am. Chem. Soc. 2013, 135, 659-668. K. Grubel, A. R. Marts, S. M. Greer, D. L. Tierney, C. J. Allpress, S. N. Anderson, B. J. Laughlin, R. C. Smith, A. M. Arif, L. M. Berreau, “Photoinitiated Dioxygenase-type Reactivity of Open-shell 3d Divalent Metal Complexes,” Eur. J. Inorg. Chem. 2012, 4750-4757. R. A. Allred, D. C. Bebout, A. M. Arif, and L. M. Berreau, “Mercury Coordination Chemistry of a Nitrogen/Thioether Sulfur Ligand having an Internal Hydrogen Bond Donor: Generation of a Thioether-coordinated Dimercurous Complex,” Main Group Chemistry 2012, 11, 53-67. C. J. Allpress, A. M. Arif, L. M. Berreau, “Photochemically-initiated Oxidative Carbon-carbon Bond Cleavage Reactivity in Chlorodiketonate Ni(II) Complexes,” Chem. Eur. J. 2011, 17, 14962-14973. K. Grubel, Brynna J. Laughlin, T. R. Maltais, R. C. Smith, A. M. Arif, L. M. Berreau, “Photochemically-induced Dioxygenase-type CO-release Reactivity of Group 12 Metal Flavonolate Complexes,” Chem. Commun. 2011, 47, 10431-10433. K. Grubel, G. Ingle, A. L. Fuller, A. M. Arif, L. M. Berreau, “Influence of Water on the Formation of O2-reactive Divalent Metal Enolate Complexes of Relevance to Acireductone Dioxygenases,” Dalton Trans. 2011, 40, 10609-10620. L. M. Berreau, T. Borowski, K. Grubel, C. J. Allpress, J. P. Wikstrom, M. E. Germain, E. V. Rybak-Akimova, D. L. Tierney, “Mechanistic Studies of the O2-dependent Aliphatic Carbon-carbon Bond Cleavage Reaction of a Nickel Enolate Complex,” Inorg. Chem. 2011, 50, 1047-1057. K. Rudzka, K. Grubel, A. M. Arif, L. M. Berreau, “A Hexanickel Enediolate Cluster is Generated in a Acireductone Dioxygenase Model Reaction,” Inorg. Chem. 2010, 49, 7623-7225. J. J. Danford, A. M. Arif, L. M. Berreau, “Thioester Hydrolysis Promoted by an Mononuclear Zinc Complex,” Inorg. Chem. 2010, 49, 778-780. K. Grubel, A. L. Fuller, B. M. Chambers, A. M. Arif, L. M. Berreau, “O2-dependent Aliphatic Carbon-carbon Bond Cleavage Reactivity in a Ni(II) Enolate Complex having A Hydrogen Bond Donor Microenvironment; Comparison with Hydrophobic Analog,” Inorg. Chem. 2010, 49, 1071-1081. K. Grubel, K. Rudzka, A. M. Arif, L. M. Berreau, “Synthesis, Characterization, and Ligand Exchange Reactivity of a Series of First Row Divalent Metal 3-Hydroxyflavonolate Complexes,” Inorg. Chem. 2010, 49, 82-96. J. J. Danford; P. Dobrowolski; L. M. Berreau, “Thioester Hydrolysis Reactivity of an Fe(III)Zn(II) Complex,” Inorg. Chem. 2009, 48, 11352-11361. M. K. Walsh, R. A. Bombyk, A. Wagh, A. Bingham, L. M. Berreau, “Synthesis of Lactose Monolaurate as Influenced by Various Lipases and Solvents,” J. Mol. Cat. B: Enzymatic 2009, 60, 171-177. J. J. Danford, A. M. Arif, L. M. Berreau, “1-Ethyl-3-methylimidazolium trichlorochromate(II),” Acta Cryst. E. 2009, E65, m227. K. Rudzka, A. M. Arif, L. M. Berreau, “A Trinuclear Ni(II) Enediolate Complex: Synthesis, Characterization, and O2 Reactivity,” Inorg. Chem. 2008, 47, 10832-10840. G. K. Ingle, R. W. Watkins, A. M. Arif, L. M. Berreau, “Divalent Metal Complexes of an Amide-appended N3O-donor ligand: Synthesis, Structural and spectroscopic Features, and Amide Methanolysis Reactivity,” J. Coord. Chem. 2008, 61, 61-77.