Xian, Ming - Washington State University

个人简介

Dr. Ming Xian received his B.S. in chemistry from Nankai University, China. He then joined Professor Jin-Pei Cheng’s group at Nankai for his early graduate study. In 1999, he moved to the Wayne State University to continue his research under Professor Peng George Wang. After received his Ph.D. in organic chemistry in 2003, he did postdoctoral research with Professor Amos B. Smith, III as a DOD postdoctoral fellow at the University of Pennsylvania. In August 2006, he joined the faculty at the Washington State University in the Department of Chemistry. Experience 2017— Ralph G. Yount Distinguished Professor, Washington State University, Pullman, WA 2016– Associate Chair for Graduate Studies, Chemistry, WSU, Pullman, WA 2015- current Professor in Chemistry, Washington State University, Pullman, WA 2011 – 2014 Associate Professor in Chemistry, Washington State University, Pullman, WA 2006 – 2011 Assistant Professor in Chemistry, Washington State University, Pullman, WA Professional Service and Awards World Science Leaders’ Lectureship, Tsukuba University, Japan, (2016) Tohoku Medical Society Lectureship, Tohoku University, Japan (2013, 2016) Mid-Career Achievement Award in Scholarship/Research/Creative Activities, Washington State University (2013) NIH Study Section Member-the Fellowship panel on Chemistry, Biochemistry, and Biophysics F04-WL (2012-current) Chair-Elect, American Chemical Society Washington-Idaho Border Section (2013) Teva USA Scholar Award, American Chemical Society (2012) Chinese-American Chemistry & Chemical Biology Professors Association (CAPA) Distinguished Faculty Award (2012) NSF CAREER Award (2009) Young Faculty Achievement Award, Washington State University (2009) Thieme Chemistry Journals Award (Synthesis, Synlett, Synfacts) (2009) U. S. Army Prostate Cancer Research Program Postdoctoral Fellowship (2003)

研究领域

The core of Dr. Xian’s research interests comprises the desire to combine organic synthesis with bioorganic chemistry to examine, understand, and solve problems of biological and medicinal significance. Currently our group is working on the following projects: Bioorthogonal reactions of S-nitrosothiols and new methods for the study of protein S-nitrosylation Synthetic applications of S-nitrosothiols Controllable hydrogen sulfide donors New methods for the detection of hydrogen sulfide in biological systems New chemical tools for reactive sulfur species research The development of bio-based materials Synthetic methodology development

近期论文

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Hamsath, A.; Xian, M. Trityl Thionitrite. Encyclo. Reagents for Org. Syn. 2019. Wang, Y.; Yang, C. T.; Xu, S.; Chen. W.; Xian, M. A hydrogen sulfide (H2S) mediated tandem reaction of selenenyl-sulfides and its application in fluorescent probe development. Org. Lett. 2019, in press. Chen, W.; Matsunaga, T.; Neill, D. L.; Yang, C. T.; Akaike, T.; Xian, M. Rational design of a dual-reactivity based fluorescent probe for visualizing intracellular HSNO. Angew. Chem. Int. Ed. 2019, DOI: 10.1002/anie.201908950. Liu, J.; Liu, M.; Zhang, X.; Wei, X.; Wang, J.; Xian, M.; Guo, W. Exploring cysteine regulation in cancer cell survival with a highly specific “Lock and Key” fluorescent probe for cysteine. Chem. Sci. 2019, Wu, J.; Chen, A.; Zhou, Y.; Zheng, S.; Yang, Y.; An, Y.; Xu, K.; He, H.; Kang, J.; Luckanagull, J. A.; Xian, M.; Xiao, J.; Wang, Q. Novel H2S-releasing hydrogel for wound repair via in situ polarization of M2 macrophages. Biomaterials 2019, 222, 119398. Hu, Y.; Li, X.; Fang, Y.; Shi, W.; Li, X.; Chen, W.; Xian, M.; Ma, H. Reactive oxygen species-triggered off-on fluorescent donor for imaging hydrogen sulfide delivery in living cells. Chem. Sci. 2019, 10, 7690-7694. Yang, C. T.; Wang, Y.; Marutani, E.; Ida, T.; Ni, X.; Xu, S.; Chen, W.; Zhang, H.; Akaike, T.; Ichinose, F.; Xian, M. Data-driven identification of hydrogen sulfide scavengers. Angew. Chem. Int. Ed. 2019, 58, 10898-10902. This work was highlighted by Chemical & Engineering News 2019, V97, issue 26: https://cen.acs.org/synthesis/medicinal-chemistry/Datamining-hydrogen-sulfide-antidote/97/i26?utm_source=Newsletter&utm_medium=Newsletter&utm_campaign=CEN Hamsath, A.; Wang, Y.; Yang, C. T.; Xu, S.; Canedo, D.; Chen, W.; Xian, M. Acyl selenyl sulfides as the precursors for reactive sulfur species (hydrogen sulfide, polysulfide, and selenylsulfide). Org. Lett. 2019, 21, 5685-5688. Wang, H.; Xu, Y.; Rao, L.; Yang, C. T.; Yuan, H.; Gao, T.; Chen, X.; Sun, H.; Xian, M.; Liu, C.; Liu, C. A ratiometric fluorescent probe for monitoring endogenous methylglyoxal in living cells and diabetic blood samples. Anal. Chem. 2019, 91, 5646-5653. Li, H.; Liu, H.; Chen, Z.; Zhao, R.; Wang, Q.; Ran, M.; Xia, Y.; Hu, X.; Liu, J.; Xian, M.; Xun, L. Using resonance synchronous spectroscopy to characterize the reactivity and electrophilicity of biologically relevant sulfane sulfur. Redox Biol. 2019, 24, 101179. Neill, D. L.; Chang, Y. C.; Chen, W.; Li, L.; Xian, M. A smart-phone based device for the detection of sulfane sulfurs in biological systems. Sens. Actuator B-Chem. 2019, 292, 263-269. Yang, C. T.; Devarie-Baez, N. O.; Hamsath, A.; Fu, X. D.; Xian, M. S-Persulfidation: chemistry, chemical biology, and significance in health and disease. Antioxid. Redox Signal. 2019, in press. Zhang, Y.; Xing, Y.; Xian, M.; Shuang, S.; Dong, C. Folate targeting and bovine serum albumin gated mesoporous silica nanoparticles as a redox-responsive carrier for epirubicin release. New J. Chem. 2019, 43, 2694-2701. Jiao, Y.; Sun, H.; Jia, Y.; Liu, Y.; Xian, M.; Shuang, S.; Dong, C. Functionalized fluorescent carbon nanoparticles for sensitively targeted of folate-receptor-positive cancer cells. Microchem. J. 2019, 146, 464-470. Guo, W.; Li, D.; You, Y.; Li, W.; Hu, B.; Zhang, S.; Miao, L.; Xian, M.; Zhu, Y.; Shen, X. Cystathionine γ-lyase deficiency aggravates obesity-related insulin resistance via FoxO1-dependent hepatic gluconeogenesis. FASEB J. 2019, 33, 4212-4224. Zheng, Z.; Chen, A.; He, H.; Chen, Y.; Chen, J.; Albashari, A. A.; Li, J.; Yin, J.; He, Z.; Wang, Q.; Wu, J.; Wang, Q.; Kang, J.; Xian, M.; Wang, X.; Xiao, J. pH and enzyme dual-responsive releasing of hydrogen sulfide for disc degeneration therapy. J. Mater. Chem. B, 2019, 7, 611-618. Kakinohana, M.; Marutani, E.; Tokuda, K.; Kida, K.; Kosugi, S.; Kasamatsu, S.; Magliocca, A.; Ikeda, K.; Kai, S.; Sakaguchi, M.; Hirai, S.; Xian, M.; Kaneki, M.; Ichinose, F. Breathing hydrogen sulfide prevents delayed paraplegia in mice. Free Radical Biol. Med. 2019, 131, 243-250. Luo, Y.; Song, Y.; Zhu, C.; Li, S.; Xian, M.; Wai, C. M.; Lin, Y.; Du, D. Visualization of endogenous hydrogen sulfide in living cells based on Au nanorods@silica enhanced fluorescence. Anal. Chim. Acta 2019, 1053, 81-88. Xu, S.; Hamsath, A.; Neill, D. L.; Wang, Y.; Yang, C. T.; Xian, M. Strategies for the design of donors and precursors of reactive sulfur species. Chem. Eur. J. 2019, 25, 4005-4016. Yang, C. T.; Chen, L.; Chen, W. L.; Li, N.; Chen, M. J.; Li, X.; Zheng, X.; Zhao, Y.; Wu, Y. X.; Xian, M.; Liu, J. Hydrogen sulfide primes diabetic wound to close through inhibition of NETosis. Mol. Cell. Endocrinol. 2019, 480, 74-82.