个人简介

B.S. in Chemistry, 1996, St. John's University, NY M.S. in Biology, 1998, St. John's University, NY Ph.D. in Chemistry, 2005, Columbia University, NY Postdoctoral Researcher, 2006-2008, University of Oxford, UK Postdoctoral Researcher, 2009-2010, University of Colorado, Boulder

研究领域

Biophysical Chemistry

Nuclear Magnetic Resonance (NMR) is a powerful technique to elucidate the structure and dynamics of biological macromolecules. NMR can provide information in atomic detail about well-folded soluble proteins, integral membrane and membrane associated proteins, ligand-protein interactions, protein aggregates, and even partially folded proteins. Approximately one-third of all proteins are located in biological membranes. Membrane proteins have diverse biological functions, and it is estimated that they constitute at least half of all therapeutic drug targets. Structural elucidation of membrane proteins remains challenging, and less than 2% are structurally characterized. We utilize both solution and solid state NMR techniques to investigate membrane proteins in solution and in their native environment, in membranes. Additional research interests include proteins associated with the development of Huntington's disease and stabilizing agents which protect biological macromolecules against the lethal effects of freezing and drying in vitro and in live cells.

近期论文

查看导师新发文章 （温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

Monterroso RA, Masters; Fan M; Argyle MD, Varga K, Dyar D, Tang J, Sun Q, Towler BF, Elliot KW, Kammen D; Characterization of the Mechanism of Gasification of a Powder River Basin Coal with a Composite Catalyst for Producing Desired Syngases and Liquids. Applied Catalysis-A 475:116-126, (2014)http://dx.doi.org/10.1016/j.apcata.2014.01.007 Tohgha U, Deol KK, Porter AG, Bartko SG, Choi JK, Leonard BM, Varga K, Kubelka J, Muller G, Balaz M. Ligand Induced Circular Dichroism and Circularly Polarized Luminescence in CdSe Quantum Dots. ACS Nano, DOI: 10.1021/nn404832f (2013) http://pubs.acs.org/doi/abs/10.1021/nn404832f Tohgha U, Varga K, Balaz M; Achiral CdSe quantum dots exhibit optical activity in the visible region upon post-synthetic ligand exchange with D- or L-cysteine. Chem Commun 49: 1844-1846 (2013)http://pubs.rsc.org/en/content/articlelanding/2013/CC/C3CC37987F Wang X, Saludes JP, Zhao TX, Csakai A, Fiorini Z, Chavez SA, Li J, Gui-in Lee G, Varga K, Yin H. Targeting the lateral interactions of transmembrane domain 5 of Epstein–Barr virus latent membrane protein. Biochim Biophys Acta 1818: 2282-2289 (2012)http://www.sciencedirect.com/science/article/pii/S000527361200171X Varga K and Rice D. Solid-state NMR analysis of biomolecules: new BioSolids experiments for VNMRJ 3.2 and BioPack. Technical Note for Agilent Technologies, Inc. (2012)http://www.chem.agilent.com/Library/technicaloverviews/Public/5990-9068en_lo.pdf Warner LR, Varga K, Lange OF, Baker SL, Baker D, Sousa MC, and Pardi A. Structure of the BamC two-domain protein obtained by Rosetta with a limited NMR data set. J Mol Biol 411: 83-95 (2011)http://www.sciencedirect.com/science/article/pii/S0022283611005729 Higman VA, Varga K, Aslimovska L, Judge PJ, Sperling LJ, Rienstra CM, and Watts A. The conformation of bacteriorhodopsin loops in purple membranes resolved by solid-state MAS NMR spectroscopy. Angew Chem Int Ed, 50: 8432-8435 (2011) http://onlinelibrary.wiley.com/doi/10.1002/anie.201100730/abstract Varga K, Aslimovska L, and Watts A. Advances towards resonance assignments for uniformly-13C, 15N enriched bacteriorhodopsin at 18.8 T in purple membranes. J Biomol NMR 41: 1-4 (2008)http://link.springer.com/article/10.1007%2Fs10858-008-9235-5 Varga K, Aslimovska L, Parrot I, Dauvergne M-T, Haertlein M, Forsyth T, and Watts A. NMR crystallography: The effect of deuteration on high resolution 13C solid state NMR spectra of a 7-TM protein. Biochim Biophys Acta 1768: 3029-3035 (2007)http://www.sciencedirect.com/science/article/pii/S0005273607003847 Varga K and Watts A. Introduction to solid state NMR and its application to membrane protein-ligand binding studies, in Biophysical Analysis of Membrane Proteins. Investigating Structure and Function, Edited by Pebay-Peyroula, E., Wiley-VCH, Weinheim pp. 55-87 (2007)http://onlinelibrary.wiley.com/doi/10.1002/9783527621224.ch3/summary Varga K, Tian L, and McDermott AE. Solid state NMR study and assignments of the KcsA potassium ion channel of S. lividans. Biochim Biophys Acta 1774: 1604-1613 (2007)http://www.sciencedirect.com/science/article/pii/S1570963907002269