个人简介
Professional Employment
The Chinese University of Hong Kong
Hong Kong, China 8/2019 onwards Associate Professor, Department of Biomedical Engineering
8/2018 - present Assistant Dean (Student Affairs), Faculty of Engineering
7/2017 - 8/2019 Assistant Professor, Department of Biomedical Engineering
1/2017 - present Assistant Professor (by courtesy), School of Life Sciences
8/2016 - present Associate Member, School of Biomedical Sciences
8/2013 - 6/2017 Assistant Professor, Department of Electronic Engineering (Biomedical Engineering)
Northwestern University
Evanston, IL, USA 10/2011 - 8/2013 Croucher Foundation Postdoctoral Scholar (Adviser: Chad A. Mirkin)
Research topic: “Delineating the interactions between spherical nucleic acid nanoparticle conjugates and cells.”
Alza Corporation
Mountain View, CA, USA 6/2003 - 9/2003 Summer Research Intern, Pilot Lead Optimization Team
Developed excipient formulations that enhance the gastric/intestinal absorption of a candidate drug.
Education
California Institute of Technology
Pasadena, CA, USA 9/2006 - 6/2011 Ph.D. in Chemical Engineering (Adviser: Mark E. Davis)
Thesis title: “Pharmacological behavior of systemically administered nanoparticles of defined properties: Mechanistic investigations at the organ, tissue, and cellular levels.” [Abstract & Full Text]
Stanford University
Stanford, CA, USA 9/2001 - 6/2006 B.S. (with honors) & M.S. in Chemical Engineering (Adviser: James R. Swartz)
Thesis title: “Effect of hydrophobicity on protein production in the cell-free protein synthesis system.”
研究领域
Bottleneck of nanomedicine
Therapeutic nanoparticles are under intense development for the treatment of diseases (e.g., cancer, cardiovascular diseases) (Allen et al., Science, 2004). Through rational design of nanoparticle properties, they can enhance and sustain the delivery of drug payload to desired biological sites (Davis et al., Nat. Rev. Drug Discov., 2008). Current progress lies on perturbing the physicochemcial properties of nanomaterials (e.g., size, charge, shape, targeting ligand density) to achieve desired clinical outcomes (e.g., circulation, stability, toxicity, efficacy). For any therapeutic to exert its intended effect, and given the high cost and synthetic difficulty of pure and potent compounds, precise delivery to targeted sites is imperative. Yet, not much research effort has been directed to elucidate the mechanisms of delivery.
Despite proven success in delivery in a few organs (e.g., tumor, liver), reports on successful targeted delivery to other sites still remain scarce. From our previous work, intravenously (i.v.) injected gold nanoparticles of different sizes in the sub-micron size range (20 – 150 nm) do notnaturally accumulate inside organs except the liver and spleen (Fig.1; Choi et al., PNAS, 2011). The mere deposition of 1-2% of the injected dose in the kidney, heart, lung, and pancreas highlights the biological barriers that obstruct efficient nanoparticle entry, restricting the delivery of actual therapeutic nanoparticles for treatment of diseases arisen from these sites. This realization prompts our research group to question if nanostructures, when strategically engineered, can accumulate in these “challenging organs” in appreciable quantities.
近期论文
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Chen Z†, Li H†, Zhang L, Lee CKY, Ho LWC, Chan CKW, Yang H, Choi CHJ*. Specific delivery of oligonucleotides to the cell nucleus via gentle compression and attachment of polythymidine. ACS Appl. Mater. Interfaces, in press (2019). [Abstract & Full Text]
Ho LWC, Liu Y, Han R, Bai Q, Choi CHJ*. Nano-cell interactions of non-cationic bionanomaterials. Acc. Chem. Res., 52, 6, 1519-1530 (2019). (Invited Article for the Special Issue on "Nanomedicine and Beyond"). [Abstract & Full Text]
Chiu YTE†, Li H†, Choi CHJ*. Progress towards understanding the interactions between DNA nanostructures and the cell. Small, 15, 26, 1805416 (2019). (Invited Review for the Special Issue on "Advances in DNA Nanotechnology"). (This paper was chosen as the Inside Front Cover and was highlighted in MaterialsViews China.) [Abstract & Full Text]
Choi CKK†, Chiu YTE†, Zhuo X†, Liu Y, Pak CY, Liu X, Tse Y-L S; Wang J, Choi CHJ*. Dopamine-mediated assembly of citrate-capped plasmonic nanoparticles into stable core-shell nanoworms for intracellular applications. ACS Nano, 13, 5, 5864-5884 (2019). (This paper was chosen as the Best Paper on Materials 2019 by the HKIE Materials Division.) [Abstract & Full Text]
Zhang L, Tian XY, Chan CKW, Bai Q, Cheng CK, Chen FM, Cheung MSH, Yin B, Yang H, Yung W-Y, Chen Z, Ding F, Leung KCF, Zhang C, Huang Y, Lau JYW, Choi CHJ*. Promoting the delivery of nanoparticles to atherosclerotic plaques by DNA coating. ACS Appl. Mater. Interfaces, 11, 15, 13888-13904 (2019). (Invited Forum Article for the Special Issue on "Translational DNA Nanotechnology"). [Abstract & Full Text]
Wong SHD†, Yin B†, Yang B, Lin S, Li R, Feng Q, Yang H, Zhang L, Yang Z, Li G, Choi CHJ*, Bian L*. Anisotropic nanoscale presentation of cell adhesion ligand enhances the recruitment of diverse integrins in adhesion structures and mechanosensing‐dependent differentiation of stem cells. Adv. Funct. Mater., 29, 8, 1806822 (2019). [Abstract & Full Text]
Sy KHS, Ho LWC, Lau WCY, Ko H, Choi CHJ*. Morphological diversity, protein adsorption and cellular uptake of polydopamine-coated gold nanoparticles. Langmuir, 34, 46, 14033-14045 (2018). [Abstract & Full Text]
Yang H, Yao Y, Li H, Ho LWC, Yin B, Yung WY, Leung KCF, Mak AFT, Choi CHJ*. Promoting intracellular delivery of sub-25 nm nanoparticles via defined levels of compression. Nanoscale, 10, 15090-15102 (2018). [Abstract & Full Text]
To ACY†, Chu DHT†, Wang AR†, Li FCY, Chiu AWO, Gao DY, Choi CHJ, Kong SK, Chan TF, Chan KM, Yip KY. A comprehensive web tool for toehold switch design. Bioinformatics, 34, 16, 2862-2864 (2018). [Abstract & Full Text]
Choi CKK, Zhang L, Choi CHJ*. Efficient siRNA delivery with non-cationic carriers. Nat. Biomed. Eng., 2, 275-276 (2018). (Invited News & Views) [Abstract & Full Text]
Ding F, Mou Q, Ma Y, Pan G, Guo Y, Tong G, Choi CHJ, Zhu X, Zhang C. Crosslinked nucleic acid nanogel for effective siRNA delivery and antitumor therapy. Angew. Chem. Int. Ed., 57, 12, 3064-3068 (2018). [Abstract & Full Text]
Yin B†, Li KHK†, Ho LWC, Chan CKW, Choi CHJ*. Toward understanding in vivo sequestration of nanoparticles at the molecular level. ACS Nano, 12, 3, 2088-2093 (2018). (Invited Perspective) [Abstract & Full Text]
Chan CKW, Zhang L, Cheng CK, Yang H, Huang Y, Tian XY*, Choi CHJ*. Recent advances in managing atherosclerosis via nanomedicine. Small, 14, 4, 1702793 (2018). [Abstract & Full Text]
Choi CKK†, Zhuo X†, Chiu YTE, Yang H, Wang J, Choi CHJ*. Polydopamine-based concentric nanoshells with programmable architectures and plasmonic properties. Nanoscale, 9, 16968-16980 (2017). [Abstract & Full Text]
Li HY, Chen Z, Ho LWC, Chan PS, Li Q, Leung SC, Zhang B, Lai KL, Kwon GS, Choi CHJ, Lee TWY. Oligonucleotide-conjugated nanoparticles for targeted drug delivery via scavenger receptors class A: an in vitro assessment for proof-of-concept. Int. J. Pharm., 532, 1, 647-655 (2017). [Abstract & Full Text]
Ho LWC, Yung WY, Sy KHS, Li HY, Choi CKK, Leung KCF, Lee TWY, Choi CHJ*. Effect of alkylation on the cellular uptake of polyethylene glycol-coated gold nanoparticles. ACS Nano, 11, 6, 6085-6101 (2017). [Abstract & Full Text]
Yang H, Chen Z, Zhang L, Yung WY, Leung KCF, Chan HYE, Choi CHJ*. Mechanism for the cellular uptake of targeted gold nanorods of defined aspect ratios. Small, 12, 37, 5178-5189 (2016). [Abstract & Full Text]
Li Q, Lai KL, Chan PS, Leung SC, Li HY, Fang Y, To KWK, Choi CHJ, Gao QY, Lee TWY. Micellar delivery of dasatinib for the inhibition of pathologic cellular processes of the retinal pigment epithelium. Colloids Surf. B, 140, 278-286 (2016). [Abstract & Full Text]
Choi CKK, Li J, Wei K, Xu YJ, Ho LWC, Zhu M, To KWK, Choi CHJ*, Bian L*. A gold@polydopamine core-shell nanoprobe for long-term intracellular detection of microRNAs in differentiating stem cells. J. Am. Chem. Soc., 137, 23, 7337–7346 (2015). [Abstract & Full Text]
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