Cong, Le - Stanford University - Department of Medicine

个人简介

Honors & Awards CRI Irvington Fellow, Cancer Research Institute HHMI International Fellow, Howard Hughes Medical Institute Professional Education PhD, Harvard University, Harvard Medical School., Biological and Biomedical Sciences (2014) LHB, Harvard Medical School., Certificate in Leder Human Biology and Translational Medicine B.S., Tsinghua University, Biological Sciences, Electronic Engineering (2009) Community and International Work Neuro-engineering and Gene-editing., Cold Spring Harbor Laboratory

近期论文

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Take Risks and Constantly Challenge the Status Quo STEM CELLS AND DEVELOPMENT Cong, L. 2019 Combined Computational-Experimental Approach to Explore the Molecular Mechanism of SaCas9 with a Broadened DNA Targeting Range JOURNAL OF THE AMERICAN CHEMICAL SOCIETY Luan, B., Xu, G., Feng, M., Cong, L., Zhou, R. 2019 ; 141 (16): 6545–52 Efficient Generation of Transcriptomic Profiles by Random Composite Measurements. Cell Cleary, B., Cong, L., Cheung, A., Lander, E. S., Regev, A. 2017 ; 171 (6): 1424–36.e18 A Distinct Gene Module for Dysfunction Uncoupled from Activation in Tumor-Infiltrating T Cells CELL Singer, M., Wang, C., Cong, L., Marjanovic, N. D., Kowalczyk, M. S., Zhang, H., Nyman, J., Sakuishi, K., Kurtulus, S., Gennert, D., Xia, J., Kwon, J. Y., Nevin, J., Herbst, R. H., Yanai, I., Rozenblatt-Rosen, O., Kuchroo, V. K., Regev, A., Anderson, A. C.All Authors 2016 ; 166 (6): 1500-? In vivo gene editing in dystrophic mouse muscle and muscle stem cells SCIENCE Tabebordbar, M., Zhu, K., Cheng, J. K., Chew, W. L., Widrick, J. J., Yan, W. X., Maesner, C., Wu, E. Y., Xiao, R., Ran, F. A., Cong, L., Zhang, F., Vandenberghe, L. H., Church, G. M., Wagers, A. J. 2016 ; 351 (6271): 407-411 RBPJ Controls Development of Pathogenic Th17 Cells by Regulating IL-23 Receptor Expression. Cell reports Meyer Zu Horste, G., Wu, C., Wang, C., Cong, L., Pawlak, M., Lee, Y., Elyaman, W., Xiao, S., Regev, A., Kuchroo, V. K. 2016 ; 16 (2): 392–404 Definitive localization of intracellular proteins: Novel approach using CRISPR-Cas9 genome editing, with glucose 6-phosphate dehydrogenase as a model. Analytical biochemistry Spencer, N. Y., Yan, Z., Cong, L., Zhang, Y., Engelhardt, J. F., Stanton, R. C. 2016 ; 494: 55–67 Crystal Structure of Staphylococcus aureus Cas9 CELL Nishimasu, H., Cong, L., Yan, W. X., Ran, F. A., Zetsche, B., Li, Y., Kurabayashi, A., Ishitani, R., Zhang, F., Nureki, O. 2015 ; 162 (5): 1113-1126 In vivo genome editing using Staphylococcus aureus Cas9 NATURE Ran, F. A., Cong, L., Yan, W. X., Scott, D. A., Gootenberg, J. S., Kriz, A. J., Zetsche, B., Shalem, O., Wu, X., Makarova, K. S., Koonin, E. V., Sharp, P. A., Zhang, F. 2015 ; 520 (7546): 186-U98 Genome engineering using CRISPR-Cas9 system. Methods in molecular biology (Clifton, N.J.) Cong, L., Zhang, F. 2015 ; 1239: 197-217 Sequence determinants of improved CRISPR sgRNA design. Genome research Xu, H., Xiao, T., Chen, C. H., Li, W., Meyer, C. A., Wu, Q., Wu, D., Cong, L., Zhang, F., Liu, J. S., Brown, M., Liu, X. S. 2015 ; 25 (8): 1147–57 Global microRNA depletion suppresses tumor angiogenesis. Genes & development Chen, S., Xue, Y., Wu, X., Le, C., Bhutkar, A., Bell, E. L., Zhang, F., Langer, R., Sharp, P. A.2014; 28 (10): 1054–67 Multiplex Genome Engineering Using CRISPR/Cas Systems SCIENCE Cong, L., Ran, F. A., Cox, D., Lin, S., Barretto, R., Habib, N., Hsu, P. D., Wu, X., Jiang, W., Marraffini, L. A., Zhang, F.2013; 339 (6121): 819-823 Optical control of mammalian endogenous transcription and epigenetic states. Nature Konermann, S., Brigham, M. D., Trevino, A. E., Hsu, P. D., Heidenreich, M., Cong, L., Platt, R. J., Scott, D. A., Church, G. M., Zhang, F. 2013; 500 (7463): 472–76 Comprehensive interrogation of natural TALE DNA-binding modules and transcriptional repressor domains NATURE COMMUNICATIONS Cong, L., Zhou, R., Kuo, Y., Cunniff, M., Zhang, F. 2012 ; 3 A transcription activator-like effector toolbox for genome engineering. Nature protocols Sanjana, N. E., Cong, L., Zhou, Y., Cunniff, M. M., Feng, G., Zhang, F. 2012 ; 7 (1): 171–92 Efficient construction of sequence-specific TAL effectors for modulating mammalian transcription NATURE BIOTECHNOLOGY Zhang, F., Cong, L., Lodato, S., Kosuri, S., Church, G. M., Arlotta, P.2011; 29 (2): 149-U90