Moellentin, Dan - Husson College

个人简介

Dr. Daniel Moellentin joined Husson University School of Pharmacy in August, 2011. Previously, he taught Family Practice Residents and practiced Clinical Pharmacy for Eastern Maine Health-Systems. He earned a B.S. degree in Pharmacy at the University of Missouri in Kansas City, followed by a Pharm.D.at the University of Arkansas, School of Medical Sciences in Little Rock, Arkansas. He has extensive experience as a clinical pharmacist specialist in Internal Medicine with focus on Cardiology, Nephrology, and Hematology. He is particularly interested in drug-induced iatrogenic disorders and drug-drug interactions. He studied English writing extensively at the University of Maine at Orono, and has published several clinical articles and abstracts and acted as a reviewer for several publications. He is Board Certified by the Board of Pharmaceutical Specialties in Pharmacotherapy. Outside of work, Dan enjoys spending time with family and friends and maintaining his historic home, the birth house of General Joshua Chamberlain in Brewer. He is a strong supporter of environmental efforts and historic preservation and is on an advisory committee for the Brewer City Council. I have been lucky to have been exposed to Medical education as well as Pharmacy education for over 20 years and wish at this time to invest in the education of my students. The role of pharmacists is changing rapidly and electronic transfer of information is hastening the change. I seek to prepare my students for the clinical roles that are moving from the medical centers to the “medical home.” I have precepted many pharmacy students and been able to engage the interest and curiosity of each by reviewing pharmaceutical care from a patient’s point of view. I hope to continue to stimulate students in developing an understanding of drug therapy and its nuances in the patients they will help throughout their professional careers.

研究领域

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Dr. Zhang’ s research interests are in the area of utilizing pharmacokinetic/pharmacodynamic (PK/PD) modeling, and physiologically based pharmacokinetic (PBPK) modeling and simulation tools (Phoenix WinNonlin, Simcyp, Gastroplus, etc) to analyze analysis of preclinical and clinical PK/PD data, predict PK profile and exposure, and explore drug-drug interaction potential. One ongoing project is pharmacokinetic modeling and dose optimization of antiepileptic drugs (AEDs) in adult and pediatric patient population. The model will enhance our understanding of the absorption and disposition of various formulations of Divalproex sodium (DVP), especially the extended-release formulations. It will be valuable to design individualized DVP and other AED dosing regimens. Another research area actively pursued is to identify compounds that inhibit proliferation and self-renewal of cancer stem cells (CSCs). It has been suggested that many types of cancer are initiated from and maintained by a small population of cancer stem cells (CSCs). The CSC population produces the tumor bulk through continuous self-renewal and differentiation. The current research is to explore the molecular mechanism of anti-CSC compounds (e.g., sulforaphane) and enhance the delivery and potency of those compounds against CSCs.