Rice, Kevin P - Colby College - Department of Chemistry

个人简介

1996 - 2000 University of Wisconsin-Madison Madison, WI Ph.D. / Biochemistry 1992 - 1996 Colby College Waterville, ME B.A. / Chemistry-Biochemistry 2013-present Colby College Waterville, ME Associate Professor, Department of Chemistry 2007-2013 Colby College Waterville, ME Assistant Professor, Department of Chemistry 2005-2007 Colby College Waterville, ME Visiting Assistant Professor, Department of Chemistry 2004-2005 Yale University New Haven, CT Associate Research Scientist, Department of Pharmacology 2000-2004 Yale University New Haven, CT Postdoctoral Associate, Department of Chemistry

研究领域

At COA Sean serves as part of the marine science faculty, and believes strongly in placing students in the field environment to provide the best possible experiential education. This includes numerous field trips on the ocean and visits to the Colleges offshore islands. As a researcher, Sean is involved in several projects as a principal investigator. Studies include: photo-identification and biopsy of finback and humpback whales, working at sites that vary from the remote field site of Mount Desert Rock, located 25 miles offshore in the Gulf of Maine, to the Antarctic Peninsula; bioacoustic assessments of whale-shipstrike interactions; and examinations of baleen whale and pinniped foraging ecology using stable isotopes. He is also the director of the Marine Mammal Stranding Response Program at College of the Atlantic. Much of Sean’s background is in the field of fishery-marine mammal interactions. He spent 10 years in Newfoundland as part of the Whale Disentanglement team, a group that releases large entangled whales from fishing gear. In Maine he is trained as part of a first response team that performs a similar function, coordinated by the Center for Coastal Studies, and regularly consults with the federal and state governments on disentanglement activities. He has worked on several projects that successfully designed alarms for fishing gear that reduce marine mammal entanglements.

近期论文

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Li Y, Praggastis VA, Ji W, Zhou HJ, He Y, Ghazvinian R, Cincotta DJ, Sartorelli AC, Rice KP*, Min W* (2014) “Carbamoylating activity associated with the activation of the antitumor agent laromustine inhibits angiogenesis by inducing ASK1-dependent endothelial cell death” PLoS ONE, v9:7, e103224 *Co-corresponding authors Rice KP, Klinkerch EJ, Gerber SA, Schleicher TR, Kraus TJ, and Buros CM (2012) “Thioredoxin reductase is inhibited by the carbamoylating activity of the anticancer sulfonylhydrazine drug Laromustine” Mol Cell Biochem, v370(1-2). pp. 199-207. Praggastis VA and Rice KP (2010) “Small molecule Inhibitors of DNA base excision repair” Encyclopedia of the Life Sciences, Wiley Press. URL: www.els.net. Ishiguro K, Rice AM, Rice KP, and Sartorelli AC (2009) “Inhibition of all-trans retinoic acid-induced granulocytic differentiation of WEHI-3B D+ cells by forced expression of SCL (TAL1) and GATA-1”, Leukemia Res. v33:9. pp. 1249-1254. Frederick AM, Davis ML, and Rice KP. (2009) “Inhibition of human DNA polymerase beta by the anticancer prodrug Cloretazine” Biochemical and Biophysical Research Communications. v378. pp 419-423. Lin ZP, Zhu YL, Johnson DR, Rice KP, Nottoli T, Hains BC, McGrath J, Waxman SG, and Sartorelli AC. (2008) “Disruption of camp and PGE2 transport by Mrp4 deficiency alters cAMP-mediated signaling and nociceptive response” Molecular Pharmacology. v73:1. pp 243-251. Rice KP, Penketh PG, Shyam K, and Sartorelli AC (2005) “Differential inhibition of cellular glutathione reductase activity by isocyanates generated from the antitumor prodrugs CloretazineTM and BCNU”, Biochem Pharmacol. v69. pp. 1463-1472. Schneider TL, Mathew RS, Rice KP, Tamaki K, Wood JL, and Schepartz A (2005) “Increasing the kinase specificity of k252a by protein surface recognition” Org Lett. v7:9. pp. 1695-1698. Rice KP, Eggler AL, Sung P, and Cox MM (2001) “DNA pairing and strand exchange by the E. coli RecA and yeast Rad51 proteins: On the importance of not getting stuck” J Biol Chem v276. pp. 38570-38581. Cox MM and Rice KP (2001) “Recombinational DNA Repair in Bacteria: Postreplication” Encyclopedia of the Life Sciences, Macmillan Press. URL: www.els.net. Rice KP, Chaput JC, Cox MM, and Switzer CY (2000) “RecA Protein Promotes Strand Exchange with Substrates Containing Isoguanine and 5-Methyl Isocytosine” Biochemistry, 39. pp.10177-10188.