Schultz, Peter - The Scripps Research Institute

个人简介

Peter G. Schultz did his undergraduate and graduate work at the California Institute of Technology. His thesis work with Peter Dervan resulted in the first synthetic molecules (polypyrrole amides) that sequence-selectively cleave DNA. In 1985, after postdoctoral studies at the Massachusetts Institute of Technology with Chris Walsh, he joined the faculty of the University of California at Berkeley, where he was Professor of Chemistry, Principal Investigator at Lawrence Berkeley National Laboratory and an Investigator of the Howard Hughes Medical Institute. Schultz joined the faculty of Scripps in 1999 where he is currently the Scripps Family Professor of Chemistry. He founded and was the Institute Director of the Genomics Institute of the Novartis Research Foundation (GNF) in San Diego, CA from 1999 to 2010 and more recently (2012) the California Institute for Biomedical Research (CALIBR), a not-for-profit institute focused on early stage translational research. In addition, Schultz is a founder of Affymax Research Institute, Syrrx, Kalypsys, Phenomix, Symyx Therapeutics, Ilypsa, Ambrx, Ardelyx, and Wildcat Technologies, pioneers in the application of diversity based approaches to problems in chemistry, materials science and medicine. His awards include the Waterman Award of the National Science Foundation, membership in the National Academy of Sciences and National Institute of Medicine, the Wolf Prize in Chemistry, the Paul Ehrlich Prize, the Arthur C. Cope Award of the American Chemical Society, and the Solvay Prize. He has coauthored 500 scientific publications and trained over 300+ graduate students and postdoctoral fellows, many of whom are on the faculties of major research institutions around the world.

研究领域

Biological Chemistry Our research program combines the tools and principles of chemistry with the molecules and processes of living cells to synthesize new molecules and molecular assemblies with novel physical, chemical and biological functions. By studying the structure and function of the resulting molecules, new insights can be gained into the mechanisms of complex biological and chemical systems. Active research projects span the interface of biology, chemistry, and materials science, and include: the development and application of methods for adding new building blocks to the genetic codes of prokaryotic and eukaryotic organisms the application of molecular diversity to problems in biological structure, recognition and catalysis, drug discovery, and materials science chemical and genomics studies of stem cell biology, oncogenesis and orphan/neglected diseases generation and characterization of catalytic antibodies

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Campbell, D.A., Gong, B., Kochersperger, L.M., Yonkovich, S., Gallop, M.A., Schultz, P.G. "Antibody-Catalyzed Prodrug Activation." J. Am. Chem. Soc., 116:2165-2166, 1994. Chung, H., Schultz, P.G. "Probing Ras Function with Unnatural Amino Acids." Chemistry & Biology, 1:vi-vii, 1994. Uno, T., Gong, B., Schultz, P.G. "Stereoselective Antibody-Catalyzed Oxime Formation." J. Am. Chem. Soc., 116:1145-1146, 1994. Pei, D., Schultz, P.G. "Artificial Nucleases." Nucleases, Cold Spring Harbor Laboratory, 317-340, 1993. Angeles, T.S., Smith, R.G., Darsley, M.J., Sugasawara, R., Sanchez, R.I., Kenten, J., Schultz, P.G., Martin, M.T. "Isoabzymes: Structurally and Mechanistically Similar Catalytic Antibodies from the Same Immunization." Biochemistry, 32:12128-12135, 1993. Chung, H.H., Benson, D.R., Cornish, V.W., Schultz, P.G. "Probing the Role of Loop 2 in Ras Function with Unnatural Amino Acids." Proc. Natl. Acad. Sci. (USA), 90:10145-10149, 1993. Judice, J.K., Gamble, T.R., Murphy, E.C., de Vos, A.M., Schultz, P.G. "Probing the Mechanism of Staphylococcal Nuclease with Unnatural Amino Acids: Kinetic and Structural Studies." Science, 261:1578-1581, 1993. Cho, C.Y., Moran, E.J., Cherry, S.R., Stephans, J.C., Fodor, S.P.A., Adams, C.L., Sundaram, A., Jacobs, J.W., Schultz, P.G. "An Unnatural Biopolymer." Science, 261:1303-1305, 1993. Schultz, P.G., Lerner, R.A. "Antibody Catalysis of Difficult Chemical Transformations." Acc. Chem. Res." 26(8):391-395, 1993, . Chung, H.H., Benson, D.R., Schultz, P.G. "Probing the Role of Lysine 16 in Ras p21 Protein with Unnatural Amino Acids." J. Am. Chem. Soc., 115(14):6414-6415, 1993. Mendel, D., Ellman, J., Schultz, P.G. "Protein Biosynthesis with Conformationally Restricted Amino Acids." J. Am. Chem. Soc., 115(10):4359-4360, 1993. Sarvetnick, N., Gurushanthaiah, D., Han, N., Prudent, J., Schultz, P., Lerner, R. "Increasing the Chemical Potential of the Germ-line Antibody Repertoire." Proc. Nat. Acad. Sci. (USA), 90:4008-4011, 1993. Hsieh, L.C., Yonkovich, S., Kochersperger, L., Schultz, P.G. "Controlling Chemical Reactivity with Antibodies." Science, 260:337-339, 1993. Lesley, S.A., Patten, P.A., Schultz, P.G. "A Genetic Approach to the Generation of Antibodies with Enhanced Catalytic Activities." Proc. Natl. Acad. Sci. (USA), 90:1160-1165, 1993. Skerker, P.S., Jacobs, J.W., Clark, D.S., Schultz, P.G. "Probing a Catalytic Antibody Active Site Using Spin-Labelled Haptens." BioMed. Chem. Lett., 2:285-288, 1993. Chung, H.H., Benson, D.R., Schultz, P.G. "Probing the Structure and Mechanism of Ras Protein with an Expanded Genetic Code." Science, 259:806-809, 1993. Scanlan, T., Schultz, P.G. "Recent Advances in Catalytic Antibodies" Advances in Detailed Reaction Mechanisms" 2:1-22, 1992, . Jackson, D.Y., Schultz, P.G. "Progress Toward the Generation of Antibodies Containing Catalytic Dyads." New Aspects of Organic Chemistry II, 21:469-475, 1992. Ellman, J.A., Volkman, B.F., Mendel, D., Schultz, P.G., Wemmer, D.E. "Site-Specific Isotopic Labelling of Proteins for NMR Studies." J. Am. Chem. Soc., 114:7959-7961, 1992. Schultz, P.G., Shokat, K.M. "Catalytic Antibodies: An Overview of Design Strategies and Their Applications." Welch Symposium Proceedings, pp. 19-42, 1991.