Nagle, Jeffrey K - Bowdoin College - Department of Chemistry

个人简介

Ph. D. 1979 University of North Carolina at Chapel Hill A. B. 1975 Earlham College, Richmond, Indiana

研究领域

My students and I are studying the effects of environmental mercury in various systems (soil, sphagnum bogs, salmonid gastrointestinal tracts, and two species of fish pathogens) and how this toxic metal is providing selective pressure in the evolution of mercury-resistant bacterial strains. In selecting for mercury-resistant microbial strains, the metal is also responsible for the co-selection of antibiotic-resistance determinants because genes responsible for both antibiotic- and mercury-resistance are linked genetically. Mercury is a by-product of various industrial applications, in particular it is found in emissions from coal-fired electrical generation plants in the Midwest. Atmospheric mercury is then deposited in the Maine environment via liquid precipitation. Hence, over time, not only does mercury pose a serious environmental health threat, bacterial strains are evolving that show an increased incidence of resistance to antibiotics. Conceivably, these genes could then be transferred horizontally to pathogens, making treatments of infectious disease with antibiotics non-efficacious.

近期论文

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Nagle, J. K. "Atomic Polarizability and Electronegativity", J. Am. Chem. Soc. 1990, 112, 4741-4747. 24. Nagle, J. K.; *LaCasce, J. H., Jr.; Dolan, P. J., Jr.; Corson, M. R.; Assefa, Z.; Patterson, H. H. "Photoluminescence and Electronic Structures of Tl2Pt(CN)4 and Tl[Au(CN)2]: Evidence for Direct Thallium-Gold Interactions", Mol. Cryst. Liq. Cryst. 1990, 181, 359-366. 23. Ziegler, T.; Nagle, J. K.; Snijders, J. G.; Baerends, E. J.; Ravenek, W. "A Theoretical Study on the Electronic Structures and Absorption Spectra of Pt(CN)42- and Tl2Pt(CN)4 Based on Density Functional Theory Including Relativistic Effects", J. Am. Chem. Soc. 1989, 111, 5631-5635. 22. Balch, A. L.; Fossett, L. A.; Nagle, J. K.; Olmstead, M. M. "Nearly Linear Rh(I) Aggregates. Chemical and Spectroscopic Behavior of [Rh3(CNCH3)6{µ-(Ph2PCH2)2PPh}2]3+ and Its Oxidation Products", J. Am. Chem. Soc. 1988, 110, 6732-6738. 21. Nagle, J. K.; *Brennan, B. A. "Luminescent Exciplex Formation Involving Tetrakis(µ-diphosphito)diplatinate(II) and Thallium(I) In Aqueous Solution", J. Am. Chem. Soc. 1988, 110, 5931-5932. 20. Balch, A. L.; Nagle, J. K.; Oram, D. E.; Reedy, P. E., Jr. "Oxidative Additions and Luminescence Involving Ir-Au-Ir Chains Formed by Binding of Gold(I) to the Metallomacroycle Ir2(CO)2Cl2{µ-Ph2PCH2)2AsPh}2", J. Am. Chem. Soc. 1988, 110, 454-462. 19. Nagle, J. K.; Balch, A. L.; Olmstead, M. M. "Tl2Pt(CN)4: A Noncolumnar, Luminescent Form of Pt(CN)42- Containing Pt-Tl Bonds", J. Am. Chem. Soc. 1988, 110, 319-321. 18. *LaCasce, J. H., Jr.; *Turner, W. A.; Corson, M. R.; Dolan, P. J., Jr.; Nagle, J. K. "Magnetic Field Effects on the Luminescence of Cs[Au(CN)2] at Low Temperatures", Chem. Phys. 1987, 118, 289-294. 17. Balch, A. L.; Nagle, J. K.; Olmstead, M. M.; Reedy, P. E., Jr. "Formation of Luminescent, Bent Ir-Tl-Ir and Ir-Pb-Ir Chains through the Binding of Thallium(I) and Lead(II) to the Iridium Metallomacroycle Ir2(CO)2Cl2{µ-(Ph2PCH2)2AsPh}2", J. Am. Chem. Soc. 1987, 109, 4123-4124. 16. *Rodman, G. S.; Nagle, J. K. "The Synthesis, Isolation, and Characterization of Tris(8-quinolinolato-N1,O8)ruthenium(III)", Inorg. Chim. Acta 1985, 105, 205-208. 15. Markert, J. T.; Blom, N.; Roper, G.; *Perregaux, A. D.; Nagasundaram, N.; Corson, M. R.; Ludi, A.; Nagle, J. K.; Patterson, H. H. "Luminescence of Cesium Dicyanoaurate(I). Evidence for Extended Au(I)-Au(I) Interactions in Two Dimensions", Chem. Phys. Lett. 1985, 118, 258-262. 14. *Reisch, G. A.; *Turner, W. A.; Corson, M. R.; Nagle, J. K. "Magnetic Field Effects on the Lifetime and Luminescence Spectrum of Tetrakis(µ-diphosphito)diplatinate(II)", Chem. Phys. Lett. 1985, 117, 561-565. 13. Nagle, J. K.; Meyer, T. J. "Flash Photolysis of a Photoactive Ruthenium Complex Mixture", Inorg. Chem. 1984, 23, 3663-3665. 12. *Heuer, W. B.; *Totten, M. D.; *Rodman, G. S.; *Hebert, E. J.; *Tracy, H. J.; Nagle, J. K. "Electron-Transfer Reactions and Luminescent Quantum Yield of the Triplet Excited State of Tetrakis[µ-diphosphito(2-)-P,P']diplatinate(II)", J. Am. Chem. Soc. 1984, 106, 1163-1164. 11. Markert, J. T.; *Clements, D. P.; Corson, M. R.; Nagle, J. K. "Phosphorescent Lifetime and Quantum Yield Measurements of K4Pt2(H2P2O5)4 from 1.6 K to 300 K", Chem. Phys. Lett. 1983, 97, 175-179. 10. Durham, B.; Caspar, J. V.; Nagle, J. K.; Meyer, T. J. "Photochemistry of Ru(bpy)32+", J. Am. Chem. Soc. 1982, 104, 4803-4810. 9. Nagle, J. K.; Bernstein, J. S.; Young, R. C.; Meyer, T. J. "Charge Transfer Excited States as Molecular Photodiodes", Inorg. Chem. 1981, 20, 1760-1764. 8. Rillema, D. P.; Nagle, J. K.; *Barringer, L. F., Jr.; Meyer, T. J. "Redox Properties of Metalloporphyrin Excited States, Lifetimes, and Related Properties of a Series of para-Substituted Tetraphenylporphyrin Carbonyl Complexes of Ruthenium(II)", J. Am. Chem. Soc. 1981, 103, 56-62. 7. Nagle, J. K. "Light-Induced Electron Transfer Reactions of N-Heterocyclic Ruthenium(II) Complexes", Ph. D. Thesis, University of North Carolina at Chapel Hill, Aug. 1979, 258 pp.; Avail. Univ. Microfilms Int., Order No. 8013977; Diss. Abstr. Int. B 1980, 41, 190. 6. Nagle, J. K.; Dressick, W. J.; Meyer, T. J. "Electron Transfer Reactions in the 'Abnormal' Free-Energy Region", J. Am. Chem. Soc. 1979, 101, 3993-3995. 5. Bock, C. R.; Connor, J. A.; Gutierrez, A. R.; Meyer, T. J.; Whitten, D. G.; Sullivan, B. P.; Nagle, J. K. "Estimation of Excited State Redox Potentials by Electron-Transfer Quenching. Application of Electron-Transfer Theory to Excited-State Redox Processes", J. Am. Chem. Soc. 1979, 101, 4815-4824. 4. Bock, C. R.; Connor, J. A.; Gutierrez, A. R.; Meyer, T. J.; Whitten, D. G.; Sullivan, B. P.; Nagle, J. K. "Application of Electron Transfer Theory to Excited State Redox Processes", Chem. Phys. Lett. 1978, 61, 522-525. 3. Sullivan, B. P.; Abruna, H., Finklea, H. O.; Salmon, D. J.; Nagle, J. K.; Meyer, T. J.; Sprintschnik, H. "Multiple Emissions from Charge Transfer Excited States of Ruthenium(II)-Polypyridine Complexes", Chem. Phys. Lett. 1978, 58, 389-393. 2. Young, R. C.; Nagle, J. K.; Meyer, T. J.; Whitten, D. G. "Electron Transfer Quenching of Nonemitting Excited States of Ru(TPP)(py)2 and Ru(trpy)22+", J. Am. Chem. Soc. 1978, 100, 4773-4778. 1. Nagle, J. K.; Young, R. C.; Meyer, T. J. "Chemically Catalyzed Disproportionation of Ru(bpy)32+*", Inorg. Chem. 1977, 16, 3366-3369.