个人简介

2007 Full Professor, University of Waterloo, Waterloo, Canada 2001 Associate Professor, University of Waterloo, Waterloo, Canada 1996 Assistant Professor, University of Waterloo, Waterloo, Canada 1993 Postdoctoral Fellow at the University of Pennsylvania, Philadelphia, USA 1990 Postdoctoral Fellow at the University of Toronto, Toronto, Canada 1989 Ph. D. in Chemistry at the Institut National Polytechnique de Lorraine, Nancy, France 1987 B. Sc. in Chemical Engineering at the Ecole Nationale Superieure des Industries Chimiques, Nancy, France Awards: 2001 Tier-2 Canada Research Chair Title: Characterization of Synthetic and Biological Macromolecules by Fluorescence (Renewed in 2007) 2001 Premier Research Excellence Award Title: A Tunable Bio-Compatible Drug Delivery System

研究领域

Polymer Chemistry

We are characterizing the behavior of polymers in solution using a variety of techniques. Among those techniques, fluorescence is certainly the workhorse of our research. Most polymers are synthesized and fluorescently labeled in the laboratory. The research projects aim at modeling the flexibility of polyolefins and polypeptides using fluorescence decay measurements and applying a blob-based approach. The dynamics of polypeptides random coils and rods are being investigated. The ability of polypeptides at carrying a hydrophobic drug mimic is also determined. Solutions of associative polymers have peculiar viscoelastic properties which have found applications in the oil and paint industries. We are determining the level of association of water- and oil-soluble associative polymers by fluorescence. It is correlated with the viscoelastic properties of the solutions. Specific applications: Characterization of chain folding; Characterization of the associative strength of water- and oil-soluble associative polymers; Characterization of the associations between associative polymers and colloidal particles.

近期论文

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Study of the Microcrystallization of Ethylene-Propylene Random Copolymers in Solution by Fluorescence. Zhang, M.; Duhamel, J. Macromolecules 2007, 40, 661-669. Polymer Chain Dyanmics in Solution Probed with a Fluorescence Blob Model. Duhamel, J. Acc. Chem. Res. 2006, 39, 953-960. Study of the Semidilute Solutions of Poly(N,N-dimethylacrylamide) by Fluorescence and Its Implications to the Kinetics of Coil-to-Globule Transitions. Irondi, K.; Zhang, M.; Duhamel, J. J. Phys. Chem. B 2006, 110, 2628-2637. Associations between a Pyrene-Labeled Hydrophobically Modified Alkali Swellable Emulsion Copolymer and Sodium Dodecyl Sulfate Probed by Fluorescence, Surface Tension, and Viscometry. Siu, H.; Duhamel, J. Macromolecules 2006, 39, 1144-1155. Correlations between the Viscoelastic Behavior of Pyrene-Labeled Associative Polymers and the Associations of their Fluorescent Hydrophobes. Prazeres, T. J. V.; Duhamel*, J.; Olesen, K.; Shay, G. J. Phys. Chem. B 2005, 109, 17406-17416. The Importance of Considering Non-Fluorescent Pyrene Aggregates for the Study of Pyrene-Labeled Associative Thickeners by Fluorescence. Siu, H.; Duhamel*, J. Macromolecules 2005, 38, 7184-7186. Effect of Solvent Quality toward the Association of Succinimide Pendants of a Modified Ethylene-Propylene Copolymer in Mixtures of Toluene and Hexane. Zhang, M.; Duhamel*, J. Macromolecules, 2005, 38, 4438-4446. Characterization of the Aggregates Made by Short Poly(ethylene oxide) Chains Labelled at one End With Pyrene. Siu, H.; Prazeres, T. V. J.; Duhamel*, J.; Olesen, K.; Shay, G. Macromolecules 2005, 38, 2865-2875. Comparison of the Association Level of a Pyrene-Labelled Associative Polymer Obtained from an Analysis Based on Two Different Models. Siu, H.; Duhamel*, J. J. Phys. Chem. B, 2005, 109, 1770-1780. Global Analysis of the Fluorescence Decays of a Pyrene-Labelled Polymer Using a Blob Model. Siu, H.; Duhamel*, J. Macromolecules, 2004, 37, 9287-9289. Coil-Globule Transition of Pyrene Labeled Polystyrene in Cyclohexane: Determination of Polymer Chain Radii by Fluorescence. Picarra, S.; Duhamel, J.; Fedorov, A.; Martinho*, J. M. G. J. Phys. Chem. B 2004, 108, 12009-12015. Self-Assembling Peptide as a Potential Carrier of Hydrophobic Compounds. Keyes, C.; Duhamel*, J.; Fung, S.-Y.; Bezaire, J.; Chen, P. J. Am. Chem. Soc. 2004, 126, 7522-7532. Blob Model Analysis of the pH-Induced Fluorescence Quenching of two Anthracene-Labeled Poly(2-vinylpyridine)s. Duhamel*, J. Macromolecules 2004, 37, 1987-1989. Characterization of the Distribution of Maleic Anhydride Grafted Ethylene-Propylene Copolymers by Fluorescence. Zhang, M.; Duhamel*, J.; van Duin, M.; Meessen, P. Macromolecules 2004, 37, 1877-1890. Side-Chain Dynamics of an alpha-Helical Polypeptide Monitored by Fluorescence. Duhamel*, J.; Kanagalingam, S.; O'Brien, T.; Ingratta, M. J. Am. Chem. Soc. 2003, 125, 12810-12822. Concentration Effects on the Aggregation of a Self-Assembling Oligopeptide. Fung, S.-Y.; Keyes, C.; Duhamel, J.; Chen*, P. Biophys. J. 2003, 85, 537-548. Scaling Relations Related to the Kinetics of Excimer Formation between Pyrene Groups Attached onto Poly(N,N-dimethylacrylamide)s. Kanagalingam, S.; Spartalis, J.; Cao, T.-M.; Duhamel*, J. Macromolecules 2002, 35, 8571-8577. Effect of Solvent Quality on the Level of Association and Encounter Kinetics of Hydrophobic Pendants Covalently Attached onto a Water-Soluble Polymer. Kanagalingam, S.; Ngan, C. F.; Duhamel*, J. Macromolecules 2002, 35, 8560-8570. Probing the Viscous Interior of Styrene/Maleic Anhydride Copolymer Aggregates in Water by Fluorescence Spectroscopy. Claracq, J.; Santos, S. F. C.; Duhamel*, J.; Dumousseaux, C.; Corpart, J.-M. Langmuir 2002, 18, 3829-3835. Characterisation of the Association Level of Pyrene-Labelled HASEs by Fluorescence. T. J. V. Prazeres, R. Beingessner, J. Duhamel*, K. Olesen, G. Shay, D. R. Bassett Macromolecules, 2001, 34, 7876-7884.