Jackman, Wiliam - Bowdoin College - Department of Biology

个人简介

B.S., University of Washington Ph.D., University of Oregon Postdoc, University of Colorado Boulder

研究领域

Our work is centered on the photochemistry and photophysics of luminescent platinum group molecules. Much of this effort is devoted to understanding excited state electron, energy, and atom transfer reactions, as well as exciplex (excited state complex) and excimer (excited state dimer) formation. Excited state reactions play a key role in molecular-based solar energy conversion schemes, including photosynthesis. We use optical (absorption, emission, and excitation) spectroscopies, pulsed-laser excited state lifetime measurements, and cyclic voltammetry to evaluate potential photocatalysts in such schemes and to test modern theories of electron transfer. An outgrowth of this work focuses on the effect of light absorption on relativistically influenced metal-metal bond formation. Einstein's theory of special relativity governs the behavior of particles that move at speeds approaching that of light. The electrons in platinum and related atoms provide examples of such particles, and as a consequence molecules containing these atoms experience substantial relativistic effects on their interactions with light and other atoms. An example of the type of compound we work with is provided by the molecular ion Pt2(P2O4H2)44-. This fascinating species absorbs light in the visible region of the spectrum, resulting in an intense green luminescence in water or solids. It also takes part in a rich array of photochemical reactions, including interactions with DNA, and exhibits an enhanced tendency to bond to other heavy metal atoms such as silver, gold, and thallium. Such bonding interactions result in the formation of luminescent metal-metal bonded exciplexes, an area of research that my students and I have pioneered over the past several years at Bowdoin.

近期论文

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Jeffrey C. Yu*, Zachary D. Fox*, James L. Crimp*, Hana E. Littleford*, Andrea L. Jowdry, and William R. Jackman. (2015). Hedgehog signaling regulates dental papilla formation and tooth size during zebrafish odontogenesis. Developmental Dynamics 244, 577-590. doi:10.1002/DVDY.24258 William R. Jackman, Shelby H. Davies*, David B. Lyons*, Caitlin K. Stauder*, Benjamin R. Denton-Schneider*, Andrea Jowdry, Sharon R. Aigler, Scott A. Vogel*, and David W. Stock. (2013) Manipulation of Fgf and Bmp signaling in teleost fishes suggests potential pathways for the evolutionary origin of multicuspid teeth. Evolution and Development 15:2, 107-118. doi:10.1111/ede.12021 Pawat Seritrakul*, Eric Samarut, Tenzing TS Lama*, Yann Gibert, Vincent Laudet, and William R Jackman. (2012) Retinoic acid expands the evolutionarily reduced dentition of zebrafish. The FASEB Journal 26, 5014-5024. doi:10.1096/fj.12-209304 William R. Jackman, James J. Yoo*, and David W. Stock. (2010). Hedgehog signaling is required at multiple stages of zebrafish tooth development. BMC Developmental Biology 10:119, doi:10.1186/1471-213X-10-119 Yann Gibert, Laure Bernard, Melanie Debiais-Thibaud, Franck Bourrat, Jean-Stephane Joly, Karen Pottin, Axel Meyer, Sylvie Retaux, David W. Stock, William R. Jackman, Pawat Seritrakul*, Gerrit Begemann and Vincent Laudet. (2010). Formation of oral and pharyngeal dentition in teleosts depends on differential recruitment of retinoic acid signaling. The FASEB Journal 24, 3298-3309, doi:10.1096/fj.09-147488 Yoshiyuki Yamamoto, Mardi S. Byerly, William R. Jackman, and William R. Jeffery. (2009). Pleiotropic functions of embryonic sonic hedgehog expression link jaw and taste bud amplification with eye loss during cavefish evolution. Developmental Biology 330, 200-211, doi:10.1016/j.ydbio.2009.03.003 William R. Jackman and David W. Stock. (2006). Transgenic analysis of Dlx regulation in fish tooth development reveals evolutionary retention of enhancer function despite organ loss. Proceedings of the National Academy of Sciences of the USA 103, 19390-19395. David W. Stock, William R. Jackman, and Josh Trapani. (2006). Developmental genetic mechanisms of evolutionary tooth loss in cypriniform fishes. Development 133, 3127-3137. William R. Jackman, Bruce W. Draper, and David W. Stock. (2004). FGF signaling is required for zebrafish tooth development. Developmental Biology 274, 139-157. William R. Jackman, Jolee M. Mougey*, Georgia D. Panopoulou, and Charles B. Kimmel. (2004). crabp and maf highlight the novelty of the amphioxus club-shaped gland. Acta Zoologica (Stockholm) 85, 91-99. William R. Jackman and Charles B. Kimmel. (2002). Coincident iterated gene expression in the amphioxus neural tube. Evolution and Development 4, 366-374. Lisa Maves, William R. Jackman, and Charles B. Kimmel. (2002). FGF3 and FGF8 mediate a rhombomere 4 signaling activity in the zebrafish hindbrain. Development 129, 3825-3837. William R. Jackman, James A. Langeland, and Charles B. Kimmel. (2000). islet reveals segmentation in the amphioxus hindbrain homolog. Developmental Biology 220, 16-26. James A. Langeland, Jill M. Tomsa*, William R. Jackman Jr., and Charles B. Kimmel. (1998). An amphioxus snail gene: Expression in paraxial mesoderm and neural plate suggests a conserved role in patterning the chordate embryo. Development Genes and Evolution 208, 569–577. Timothy Quinn and William R. Jackman*. (1994). Influence of diet on detection of fecal bile acids by thin-later chromatography. Journal of Wildlife Management. 58:295-299.