Kohorn, Bruce - Bowdoin College - Department of Biochemistry

个人简介

Bruce Kohorn delivers the Linnaean Professorship of Biology and Biochemistry Inaugural Lecture. The lecture, titled "From Mountains to Membranes," will be an exploration of the mechanisms that create plant cell form and function, with a concentration on the cell surface and its interaction with the cell wall.

研究领域

The Horch lab uses the cricket model system to examine the molecular neurobiological basis of a number of areas including regeneration, behavior, and development. Mainly, the lab will focus on the regeneration of interneurons in the auditory system of the cricket. Removing one ear induces auditory interneurons to sprout new dendrites, grow abnormally across the mid-line, and form synapses with intact auditory neurons from the opposite ear, both in developing as well as adult crickets. This is one of the most elegant and complex examples of neuronal regeneration known. Techniques such as dextran backfills, immunohistochemistry, and confocal microscopy will be used to understand the molecular cues involved in this phenomenon. Other projects include examining the role of octopamine on male cricket aggression and attempting to create transgenic crickets in order to examine the development of individual neurons.

近期论文

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Kohorn BD, Hoon D, Minkoff BB, Sussman MR, and Kohorn SL (2016) Rapid Oligo-Galacturonide Induced Changes in Protein Phosphorylation in Arabidopsis. Molecular Cellular Proteomics. In press, pii: mcp.M115.055368. [Epub ahead of print] Kohorn BD. (2016) Cell wall-associated kinases and pectin perception. J Exp Bot. 67:489-94 Kohorn,B.D (2015) The State of Cell Wall Pectin Monitored by Wall Associated Kinases; a Model. Plant Signaling and Behavior . 10(7):e1035854 Kohorn, B.D, Kohorn, S., Saba, N. and Matinez, V.M. (2014) Requirement for Pectin Methyl esterase and Preference for Fragmented Over Native Pectins for Wall Associated Kinase Activated, EDS1/PAD4- Dependent Stress Response in Arabidopsis. J. Biol Chem 2014: 18978-86. Kohorn, B.D., and Kohorn, S.L. (2012) The Cell Wall Associated Kinases, WAKs, As Pectin Receptors. Frontiers in Plant Science 3:88, 1-4.Kohorn, B.D., Kohorn, S.L., Todorova, T., Baptiste, G., Stansky, K., and McCullough, M. (2012) A Dominant Allele of Arabidopsis Pectin-Binding Wall-Associated Kinase Induces a Stress Response Suppressed by MPK6 but Not MPK3 Mutations. Mol. Plant 5(4):841-51 Kohorn, B.D., Kohorn, S.L., Todorova, T., Baptiste, G., Stansky, K., and McCullough, M. (2012) A Dominant Allele of Arabidopsis Pectin-Binding Wall-Associated Kinase Induces a Stress Response Suppressed by MPK6 but Not MPK3 Mutations. Mol. Plant 5(4):841-51 Kohorn, B.D., and Kohorn, S.L. (2012) The Cell Wall Associated Kinases, WAKs, As Pectin Receptors. Frontiers in Plant Science 3:88, 1-4. Kohorn, B.D. and Kohorn, S.L. (2011) The Cell Wall Associated Kinases. In; Receptor-Like Kinases in Plants: From Development to Defense. Editors: Birgit Kemmerling Frans Tax. Springer, NY Kohorn, BD, S. Johansen, A Shishido, T Todorova, R Martinez, E DeFeo, P Obregon (2009) Pectin Activation of MAP Kinase and Gene Expression is WAK2-dependent. Plant J 60, 974. Kohorn, B.D., Kobayashi, M, Johansen, S., Fischer, A, Byers, N,. (2006) Wall Associated Kinase 1 is Crosslinked in Endomembranes and Transport To The Cell Surface Requires Correct Cell Wall Synthesis. Journal Cell Science 119: 2282-2290. Kohorn, B.D., Kobayashi, M, Johansen, S., Riese, J., Huang, L-F., Koch K., Fu, S., Dotson, A., and Byers, N, (2006). An Arabidopsis Cell Wall Associated Kinase Required for Invertase Activity and Cell Growth. The Plant Journal 46:307-316. Snyders, S. and Kohorn, B.D. 2001.Disruption of thylakoid kinase activity TAK1 leads to alteration of light energy transduction. J. Biol. Chem. 276:32169-32176 Kohorn B.D. 2001. Cell Wall Associated Kinases. Curr. Opin. Cell Biol. 13:529-533 Anderson, K.A. and Kohorn, B.D. 2001. Inactivation of Arabidopsis SIP1 leads to reduced levels of sugars and drought tolerance. J. Plant Physio 158. 1215-12 Anderson, C.M., Wagner, T.A., He, Z.H., He, D., and Kohorn, B.D. 2001. WAKs : Cell wall associated kinases linking the cytoplasm to the extracellular matrix. Plant Mol. Biol47:197-206. Wagner, TA, and Kohorn, B.D. 2001. Wall associated kinases, WAKs, are expressed throughout development and are required for cell expansion. Plant Cell 13:303-18 Kohorn, B.D. 2000. Plasma membrane-cell wall contacts. Plant Physiology 124:21-38 Kohorn, B.D. 1999. Shuffling the deck; plant signaling plays a club. Trends in Cell Biol. 9: 381-383. He, Z.H., Cheeman, I., He, D. and B.D. Kohorn. 1999. A cluster of cell wall assocaited kinase genes are expressed in specific tissues of Arabidopsis. Plant Mol Biol 39: 1189-1196 Snyders, S and B.D. Kohorn. 1999. TAKs, Thylakoid Membrane Protein Kinases Associated with Energy Transduction J. Biol. Chem. 1999 274: 9137-9140 He, Z.H, He, D., and B.D. Kohorn. 1998. Requirement for the induction of a cell wall associated receptor kinase for survival during the pathogen response. The Plant J. 14: 55-63 Bernd, K. and B.D. Kohorn. 1998. Tips; six chlamydomonas nuclear suppressors that permit the translocation of proteins with mutant thylakoid signal sequences. Genetics 149:1293-1301 Bernd, K., Perret, M. and B.D. Kohorn. 1997. Protein translocation in chloroplasts; contributions from Chlamydomonas. In the Molecular Biology of Chlamydomonas. Eds. Rochaix, Goldschmidt-Clermont and Merchant. Baillet, B. and B.D. Kohorn. 1996. Hydrophobic core but not amino terminal charged residues are required for translocation of an integral thylakoid membrane protein in vivo. J. Biol. Chem. 271:18371-18374 (PDF reprint)