Gorske, Benjamin C - Bowdoin College - Department of Biochemistry

个人简介

Ph.D., Organic Chemistry, University of Wisconsin–Madison, 2007 B.A., Chemistry, Lawrence University – Appleton, WI, 1995 B.M., Piano Performance, Lawrence University – Appleton, WI, 1995

研究领域

Clonality in plants is widespread and includes species that span temporally and spatially heterogeneous environments. Yet, theory predicts that clonally reproducing plants evolve at slower rates, risk accumulating more mutations than sexuals, and potentially lack the benefits of DNA repair mechanisms afforded by meiosis. Does the apparent success of clonal plants contradict the severe costs of clonal reproduction suggested by theory? In our most recent line of research, we examine how epigenetics may confer ecological advantages to clonal plants that could outweigh these evolutionary costs. Relying to various degrees on vegetative reproduction, the capacity to conserve or reverse gene regulation changes over cell divisions has clear potential for optimization of plasticity and acclimation in response to environmental variation encountered. Clonal plants may be one of the best examples of organisms taking advantage of epigenetic acclimation as an alternative to the slower mechanisms of adaptation through natural selection. If epigenetic processes are important in matching organismal response to the environment, this may prove to be a mechanism that will buffer plants against the challenges of current and future rapid environmental changes.

近期论文

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1. “New Strategies for the Design of Folded Peptoids Revealed by a Survey of Noncovalent Interactions in Model Systems.” Gorske, B. C.; Stringer, J. R.; Bastian, B. L.; Fowler, S. A.; Blackwell, H. E. J. Am. Chem. Soc. 2009, in press. 2. “Regio- and Stereoselective Synthesis of Fluoroalkenes by Directed Au(I) Catalysis.” Gorske, B. C.; Mbofana, C. T.; Miller, S. J. Org. Lett. 2009, 11, 4318-4321. 3. “Local and Tunable n®p* Interactions Regulate Amide Isomerism in the Peptoid Backbone.” Gorske, B. C.; Bastian, B. L.; Geske, G. D.; Blackwell, H. E. J. Am. Chem. Soc. 2007, 129, 8928-8929. Highlighted by Faculty of 1000 Biology (Faculty of 1000 Biology: evaluations for Gorske BC et al J Am Chem Soc 2007 Jul 25 129 (29) :8928-9 http://www.f1000biology.com/article/id/1088560/evaluation) 4. “Tuning Peptoid Secondary Structure with Pentafluoroaromatic Functionality: A New Design Paradigm for the Construction of Discretely Folded Peptoid Structures.” Gorske, B. C.; Blackwell, H. E. J. Am. Chem. Soc.2006, 128, 14378-14387. Highlighted as a Tech Advance by Faculty of 1000 Biology (Faculty of 1000 Biology: evaluations for Gorske BC & Blackwell HE J Am Chem Soc 2006 Nov 8 128 (44) :14378-87 http://www.f1000biology.com/article/id/1050425/evaluation) 5. “Interception of Quorum Sensing in Staphylococcus aureus: A New Niche for Peptidomimetics.” Gorske, B. C.; Blackwell, H. E. Org. Biomol. Chem. 2006, 4, 1441-1445. 6. “N-[1-(Pentafluorophenyl)ethyl]acetamide.” Guzei, I. A.; Gorske, B. C.; Blackwell, H. E. Acta Crystallogr., Sect. C: Cryst. Struct. Commun. 2006, 62, o286-o288. 7. “Expedient Synthesis and Design Strategies for New Peptoid Construction.” Gorske, B. C.; Jewell, S. A.; Guerard, E. J.; Blackwell, H. E. Org. Lett. 2005, 7, 1521-1524.