Dube, Danielle - Bowdoin College - Department of Biochemistry

个人简介

A.B., Cornell University, 2000 Ph.D , University of California, Berkeley, 2005 Postdoctoral, Stanford University, 2005-2007

研究领域

My research focuses on the ways in which the nervous system controls behavior. In particular, I have been studying the control of relatively simple, rhythmic behaviors, and the modulation or alteration of these behaviors. The goal of these studies is to understand how flexibility in behavior is controlled at the level of the nervous system. Students in my lab and I have been examining the ways in which several small peptides alter the activity of the nerve cells that control the rhythmic movements of the lobster stomach. Because the lobster nervous system is relatively simple, it can be studied in much more detail than is presently possible with vertebrates; we can thus elucidate general principles which can later be applied to more complex species. In studying these problems, we record the electrical activity of individual neurons with microelectrodes and the activity of whole nerves with extracellular electrodes. These techniques are taught and used in the labs in Biology 213 (Introduction to Neuroscience), Biology 214 (Comparative Physiology), and Biology 253 (Comparative Neurobiology).

近期论文

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E. L. Clark*, M. Emmadi, K. L. Krupp*, A. R. Podilapu, J. D. Helble*, S. S. Kulkarni, and D. H. Dube, "Development of rare bacterial monosaccharide analogs for metabolic glycan labeling in pathogenic bacteria" ACS Chem. Biol., 2016, 11, 3365-3373. K. R. Farnham and D. H. Dube, "A semester-long project-oriented biochemistry laboratory based on Helicobacter pylori urease" Biochem. Mol. Biol. Educ., 2015, 43, 333-340. V. Tra* and D. H. Dube, "Chemical tools to detect and target Helicobacter pylori's glycoproteins" In Glycoscience: Biology and Medicine, T. Endo, P. Seeberger, G. Hart, C-H Wong, N. Taniguchi, ed., Springer (Japan), 2014. V. Tra* and D. H. Dube, "Glycans in pathogenic bacteria -- potential for targeted covalent therapeutics and imaging agents," Chem. Commun., 2014, 50, 4659-4673. K. Champasa*, S. A. Longwell*, A. M. Eldridge, E. A. Stemmler and D. H. Dube, "Targeted identification of glycosylated proteins in the gastric pathogen Helicobacter pylori", Mol. Cell. Proteomics, 2013, 12, 2588-2586. P. Kaewsapsak*, O. Esonu*, and D. H. Dube, "Recruiting the host's immune system to target Helicobacter pylori's surface glycans", ChemBioChem, 2013, 14, 721-726 S. A. Longwell* and D. H. Dube, "Deciphering the bacterial glycocode: recent advances in bacterial glycoproteomics", Curr. Opin. Chem. Biol., 2013, 17, 41-48 D. H. Dube. "Metabolic labeling of bacterial glycans with chemical reporters." In Bacterial glycomics: Current research, technology, and applications. Twine, S. M., ed. Horizon Scientific Press, Norfolk (UK), 2012 D. H. Dube†, B. Li†, E. J. Greenblatt, S. Nimer, A. K. Raymond* and J. J. Kohler, "A two-hybrid assay to study interactions within the secretory pathway", PLOS One, 2010, 5, e15648. [† These authors contributed equally to this work.] D. H. Dube, K. Champasa* and B. Wang*, "Chemical tools to discover and target bacterial glycoproteins",Chem. Commun., 2011, 47, 87-101. P. V. Chang, D. H. Dube and C. R. Bertozzi, "A strategy for the selective imaging of glycans using caged metabolic precursors", J. Am. Chem. Soc., 2010, 132, 9516-9518. M. B. Koenigs*, E. A. Richardson* and D. H. Dube, "Metabolic profiling of Helicobacter pylori glycosylation",Mol. BioSyst., 2009, 5, 909-912. D. H. Dube, C. L. De Graffenried and J. J. Kohler, “Regulating cell surface glycosylation with a small-molecule switch”, Meth. Enzymol., 2006, 415, 213-229. D. H. Dube†, J. A. Prescher†, C. N. Quang* and C. R. Bertozzi, “Probing mucin-type O-linked glycosylation in living animals”, Proc. Nat’l Acad. Sci. USA, 2006, 103, 4819-4824. [†These authors contributed equally to this work.] D. H. Dube and C. R. Bertozzi, “Glycans in cancer and inflammation: potential for therapeutics and diagnostics”, Nat. Rev. Drug Disc., 2005, 4, 477-488. J. A. Prescher†, D. H. Dube†, and C. R. Bertozzi, “Chemical remodeling of cell surfaces in living animals”Nature, 2004, 430, 873-877. [†These authors contributed equally to this work.] D. H. Dube and C. R. Bertozzi, “Metabolic oligosaccharide engineering as a tool for glycobiology”, Curr. Opin. Chem. Biol., 2003, 7, 1-10. S. J. Luchansky, H. C. Hang, E. Saxon, J. R. Grunwell, C. Yu, D. H. Dube and C. R. Bertozzi, “Constructing azide-labeled cell surfaces using polysaccharide biosynthetic pathways”, Meth. Enzymol., 2003, 362, 249-272.