Jeong, Jeeyon - Amherst College - Biochemistry-Biophysics

个人简介

Ph. D., Dartmouth College (2008) M. S., Pohang University of Science and Technology (2002) B. E., Yonsei University (2000) Assistant Scientist, University of Wisconsin-Madison (2014-2015) Howard Hughes Medical Institute Teaching Fellow, University of Wisconsin-Madison (2013) Postdoctoral Fellow, University of Wisconsin-Madison (2009-2014) I teach Molecular Genetics, Biochemistry, and an advanced seminar, Biology of Metals. Molecular Genetics explores the structure, function, regulation, and interaction of genes at a molecular level. Biochemistry deals with the chemical processes that relate to life, including the structure, function, and interaction of molecules; flow of energy; and metabolic pathways that occur in a cell or a living organism. Molecular Genetics and Biochemistry are closely related subfields of molecular biology highly relevant to my own area of research. My seminar focuses on the molecular and cellular biology of metals. Topics of discussion include metal homeostasis strategies, role of metals in biochemical processes, inherited metal metabolism disorders, and genetics of hyperaccumulators. We also discuss prospects of manipulating metal homeostasis to aid human health and environmental sustainability.

研究领域

My research addresses the ecological and evolutionary forces that shape systems of inheritance and the dynamics of disease in natural populations, both aspects of what could be called 'transmission biology.' In particular, I am working on how different genomic regions interact with an organism's reproductive strategy. Regions such as sex chromosomes, autosomes, and cytoplasmic components differ in their modes of inheritance and are therefore exposed to conflicting patterns of natural selection. At the same time, all of these regions are connected through their effects on individual fitness. My work addresses the resulting instability of genetic systems (at both individual and population levels), its proximal causes, and how some organisms cope or even adapt to genomic plasticity. I also have a long-standing interest in the biology of infectious diseases in natural populations. In many ways, host-pathogen interactions have conflicts of interest and instabilities that are analogous to those involved in the evolution of genetic systems. This is most clearly seen in the dynamics of "genomic parasites" (such as repetitive DNA elements or invasive mitochondrial types), but also in the general principles of horizontal transmission and co-evolution that allow antagonistic relationships to persist. Most of my current studies use the parasitic fungus Microbotryum, which causes anther-smut disease on plants of the Caryophyllaceae.

近期论文

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MacDiarmid CM, Taggart J, Jeong J, Kerdsomboon K, Eide DJ. (In Press) Activation of the yeast UBI4 polyubiquitin gene by Zap1 via an intragenic promoter is critical for zinc-deficient growth. J. Biol. Chem. Jeong J, Eide DJ. (2013) SLC39 family of metal ion transporters. Mol. Asp. Med. 34:612-619. Jeong J, Walker J, Wang F, Park JG, Palmer AE, Rorhbach M, Giunta C, Steinmann B, Eide DJ. (2012) Promotion of vesicular zinc efflux by ZIP13 and its implications for spondylocheiro dysplastic Ehlers-Danlos syndrome. Proc. Natl. Acad. Sci. 109: E3530-E3538. [Recommended by Faculty1000. http://f1000.com/prime/717969071]. Jeong J, Guerinot ML. (2009) Homing in on iron homeostasis in plants. Trends Plant Sci. 14:280-285. Jeong J, Connolly EL. (2009) Iron uptake mechanisms in plants: functions of the FRO family of ferric reductases: Plant Sci. 176:709-714. Jeong J, Guerinot ML. (2008) Biofortified and bioavailable: The golden standard for plant-based diets. Proc. Natl. Acad. Sci. 105:1777-1778. Jeong J, Cohu C, Kerkeb L, Pilon M, Connolly EL, Guerinot ML. (2008) Chloroplast Fe(III) chelate reductase activity is essential for seedling viability under iron limiting conditions. Proc. Natl. Acad. Sci. 152:2301-2308. Jeong J, Suh S, Guan C, Tsay YF, Moran N, Oh CJ, An CS, Demchenko KN, Pawlowski K, Lee Y. (2004) A nodule-specific dicarboxylate transporter from alder is a member of the peptide transporter family. Plant Physiol. 134:969-78. Lee J, Bae H, Jeong J, Lee JY, Yang YY, Hwang I, Martinoia E, Lee Y. (2004) Functional expression of a bacterial heavy metal transporter in Arabidopsis enhances resistance to and decreases uptake of heavy metals. Plant Physiol. 133:589-96. [Recommended by Faculty1000.