张明 - 同济大学

个人简介

张明博士现任同济大学医学院脑与脊髓创新中心特聘研究员，博士生导师，脑疾病与基因组学课题组负责人。曾受邀担任Nature Communications, Acta Neuropathologica, Movement Disorder, Journal of Alzhermer’s Disease, Neurobiology of Aging 等学术期刊审稿人，Alzheimer Society UK和MND Association特邀评审。教育与工作经历博士毕业于上海交通大学Bio-X研究院，师从贺林院士。2012年 - 2018年在多伦多大学从事博士后研究和Research Associate工作（合作教授：Ekaterina Rogaeva, Peter St-George Hyslop）。2018年任同济大学医学院特聘研究员。2019年入选上海市浦江人才计划。2020年入选上海市海外高层次引进人才计划。学术成绩最近的工作主要研究肌萎缩侧索硬化症等神经退行性疾病的遗传学机制。至今发表SCI收录论文51篇(第一或通讯作者文章28篇)，被引用>2300次，h-index为28（Google Scholar)。近5年发表第一或通讯作者文章19篇，包括Acta Neuropathol（3篇）, Brain（3篇） , Am J Hum Genet，Movement Disorders (2篇), Neurology和JNNP等领域知名杂志。主持一项国家自然科学基金面上项目和两项上海市科委项目。参与编写医学分子遗传学研究生教材（复旦大学出版社，2022年）。

研究领域

神经退行性疾病的多组学研究（基因组学、表观基因组学、转录组学）深度学习算法与基因变异功能预测渐冻症的单细胞和空间尺度的分子机制研究

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

Epigenetic Clock Acceleration Is Linked to Age at Onset of Parkinson's Disease Xuelin Tang, Gonzalez-Latapi P, ....... Rogaeva E, Ming Zhang#. (co-corresponding author). Movement Disorders: 2022/08/03 DNA methylation age acceleration is associated with age of onset in Chinese spinocerebellar ataxia type 3 patients Jiahao Li, Anli Shu, ....... Ming Zhang#. (corresponding author). Neurobiology of Aging: 2022/05/01 Combined epigenetic/genetic study identified an ALS age of onset modifier Ming Zhang#, Zhengrui Xi, Sara Saez-Atienzar, et al., (co-corresponding author) Acta neuropathologica communications: 2021/04/23 Genomic study of a large family with complex neurological phenotype including hearing loss, imbalance and action tremor Julien F Bally*, Ming Zhang*, Ekaterina Rogaeva, et al., (co-first author) Neurobiology of Aging: 2022/05/01 Whole-genome study of a multigenerational family with essential tremor Ming Zhang*, Mohammad Rohani*, Ekaterina Rogaeva, et al.,(co-first author). Canadian Journal of Neurological Sciences: 2021/05/05 DNA methylation age acceleration is associated with ALS age of onset and survival Ming Zhang#, Paul M McKeever, Zhengrui Xi, et al., (co-corresponding author). Acta Neuropathologica: 2020/05/01 Genetic and epigenetic study of an Alzheimer’s disease family with monozygotic triplets Ming Zhang*, Allison A Dilliott*, Roaa Khallaf, et al., (co-first author). Brain:2019/11/01 A C6orf10/LOC101929163 locus is associated with age of onset in C9orf72 carriers Ming Zhang#, Raffaele Ferrari, Maria Carmela Tartaglia, et al. (co-corresponding author). Brain: 2018/09/25 DNA methylation age-acceleration is associated with disease duration and age at onset in C9orf72 patients Ming Zhang, Maria Carmela Tartaglia, Danielle Moreno, et al.. Acta neuropathologica: 2017/08/01 Jump from pre-mutation to pathologic expansion in C9orf72 Zhengrui Xi*, Marka van Blitterswijk*, Ming Zhang*, et al. (co-first author). The American Journal of Human Genetics: 2015/06/04 Mutation analysis of CHCHD10 in different neurodegenerative diseases Ming Zhang, Zhengrui Xi, Lorne Zinman, et al.. Brain: 2015/04/01 The C9orf72 repeat expansion itself is methylated in ALS and FTLD patients Zhengrui Xi*, Ming Zhang*, Amalia C Bruni, et al. (co-first author)). Acta neuropathologica: 2015/05/01 C9orf72 and ATXN2 repeat expansions coexist in a family with ataxia, dementia, and parkinsonism Ming Zhang, Zhengrui Xi, Karen Misquitta, et al.. Movement Disorders: 2017/01 Unaffected mosaic C9orf72 case: RNA foci, dipeptide proteins, but upregulated C9orf72 expression Philip McGoldrick*, Ming Zhang*, Marka van Blitterswijk,et al.(co-first author). Neurology: 2018/01/23 Genetic and epigenetic study of ALS-discordant identical twins with double mutations in SOD1 and ARHGEF28 Ming Zhang, Zhengrui Xi, Mahdi Ghani,et al.. J Neurol Neurosurg Psychiatry: 2016/05/06 Mutation analysis of CHCHD2 in Canadian patients with familial Parkinsons disease Ming Zhang#, Zhengrui Xi, Shilun Fang,et al.(corresponding author). Neurobiology of aging: 2016/02/01 Mutation analysis of CHCHD2 and CHCHD10 in Italian patients with mitochondrial myopathy Elisa Rubino*, Ming Zhang*, Tiziana Mongini,et al.(co-first author). Neurobiology of aging: 2018/06/01 Genetic analysis of CHCHD2 and CHCHD10 in Italian patients with Parkinsons disease Elisa Rubino*, Livia Brusa*, Ming Zhang*, et al.(co-first author). Neurobiology of aging: 2017/05/01 Drug repositioning for Alzheimer’s disease based on systematic ‘omics’ data mining Ming Zhang, et al. (corresponding author). Plos One. 2016/12/22 Drug repositioning for diabetes based on'omics' data mining Ming Zhang, et al. (corresponding author). Plos One. 2015/05/06 Progesterone receptor membrane component 1 is a functional part of the glucagon-like peptide-1 (GLP-1) receptor complex in pancreatic β cells Ming Zhang, et al. Molecular & cellular proteomics 2014/11/01