张青锋 - 同济大学

个人简介

张青锋，浙江大学生化专业本科毕业，并在第二军医大学和同济大学分别获得病原生物学硕士和博士学位，并在法国巴斯德研究所完成博士后研究工作，师从国际著名分子寄生虫学专家、欧洲科学院院士Artur Scherf教授。现任职于同济大学医学院免疫学与病原生物学系，长聘教授，博士生导师，“分子病原生物学”课题组长。

研究领域

疟原虫、血吸虫等寄生虫感染宿主后需要经过一系列与宿主的适应性相互作用过程，如建立感染、致病、有性生殖、产生抗药性等。这些过程皆依赖于寄生虫对各类功能基因阶段性表达的严格调控，从而执行不同的生物学功能。张青锋教授团队以功能基因组和表观遗传整合研究为核心，以危害最大的疟原虫为研究模型，围绕寄生虫与宿主相互作用，聚焦抗原变异、致病与传播等关键互作过程中相关基因表达调控机制的共性问题，致力于阐明疟原虫与人体宿主互作的表观遗传调控网络，鉴定关键调控因子，并开展新型抗疟药物或防控措施的研发工作

近期论文

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Yu X, Wang C, Zhao Y, Tang J, Zhu M, Platon L, Culleton R, Zhu G*, Ménard D*, Zhang Q*, Cao J*. Ring-stage growth arrest: Metabolic basis of artemisinin tolerance in Plasmodium falciparum. iScience. 2022 Dec 5;26(1):105725. Cao G, Yue J, Ruan Y, Han Y, Zhi Y, Lu J, Liu M, Xu X, Wang J, Gu Q, Wen X, Gao J, Zhang Q, Kang J, Wang C*, Li F*. Single-cell dissection of cervical cancer reveals key subsets of the tumor immune microenvironment. EMBO J. 2023 Jul 10:e110757. Liu M, Han Z, Zhi Y, Ruan Y, Cao G, Wang G, Xu X, Mu J, Kang J, Dai F, Wen X, Zhang Q*, Li F*. Long-read sequencing reveals oncogenic mechanism of HPV-human fusion transcripts in cervical cancer. Translational Research. 2023 Mar;253:80-94. Xu X, Wang Y, Wang C, Guo G, Yu X, Dai Y, Liu Y, Wei G, He X, Jin G, Zhang Z, Guan Q, Pain A, Wang S, Zhang W, Young ND, Gasser RB, McManus DP*, Cao J*, Zhou Q*, Zhang Q*.Chromosome-level genome assembly defines female-biased genes associated with sex determination and differentiation in the human blood fluke Schistosoma japonicum. Molecular Ecology Resources. 2023 Jan;23(1):205-221. Shang X, Wang C, Fan Y, Guo G, Wang F, Zhao Y, Sheng F, Tang J, He X, Yu X, Zhang M, Zhu G, Yin S, Mu J, Culleton R, Cao J*, Jiang M*, Zhang Q*. Genome-wide landscape of ApiAP2 transcription factors reveals a heterochromatin-associated regulatory network during Plasmodium falciparum blood-stage development. Nucleic Acids Research. 2022. 50(6):3413-3431. Liu M, Guo G, Qian P, Mu J, Lu B, He X, Shang X, Yang G, Shen S, Liu W, Wang L, Gu L, Mu Q, Yu X, Zhao Y, Culleton R, Cao J, Jiang L, Wellems T*, Yuan J*, Jiang C*, Zhang Q*. 5-methylcytosine modification by Plasmodium NSUN2 stabilizes mRNA and mediates the development of gametocytes. PNAS. 2022. 119(9):e2110713119. Shang X, Shen S*, Tang J, He X, Zhao Y, Wang C, He X, Guo G, Liu M, Wang L, Zhu Q, Yang G, Jiang C, Zhang M, Yu X, Han J, Culleton R, Jiang L, Cao J*, Gu L*, Zhang Q*. A cascade of transcriptional repression determines sexual commitment and development in Plasmodium falciparum. Nucleic Acids Research. 2021. 49(16): 9264-9279. Lu B, Liu M, Gu L, Li Y, Shen S, Guo G, Wang F, He X, Zhao Y, Shang X, Wang L, Yang G, Zhu Q, Cao J, Jiang C, Culleton R, Wei G*, Zhang Q*. The Architectural Factor HMGB1 Is Involved in Genome Organization in the Human Malaria Parasite Plasmodium falciparum. mBio. 2021; 12(2):e00148-21. Yang M, Shang X, Zhou Y, Wang C, Wei G, Tang J, Zhang M, Liu Y, Cao J*, Zhang Q*. Full-Length Transcriptome Analysis of Plasmodium falciparum by Single-Molecule Long-Read Sequencing. Front Cell Infect Microbiol. 2021; 11:631545. Zhao Y, Wang F, Wang C, Zhang X, Jiang C, Ding F, Shen L*, Zhang Q*. Optimization of CRISPR/Cas System for Improving Genome Editing Efficiency in Plasmodium falciparum. Front Microbiol. 2021; 11:625862. Fan Y, Shen S, Wei G, Tang J, Zhao Y, Wang F, He X, Guo G, Shang X, Yu X, Ma Z, He X, Liu M, Zhu Q, Le Z, Wei G, Cao J, Jiang C*, Zhang Q*. Rrp6 Regulates Heterochromatic Gene Silencing via ncRNA RUF6 Decay in Malaria Parasites. mBio. 2020; 11:e01110-20. Yin S, Fan Y, He X, Wei G, Wen Y, Zhao Y, Shi M, Wei J, Chen H, Han J, Jiang L*, Zhang Q*. The cryptic unstable transcripts are associated with developmentally regulated gene expression in blood-stage Plasmodium falciparum. RNA Biology. 2020; 17(6):828-842. Liu M, Lu B, Fan Y, He X, Shen S, Jiang C*, Zhang Q*. TRIBE Uncovers the Role of Dis3 in Shaping the Dynamic Transcriptome in Malaria Parasites.Front Cell Infect Microbiol. 2019; 7:264. Droll D, Wei G, Guo G, Fan Y, Baumgarten S, Zhou Y, Xiao Y, Scherf A*, Zhang Q*. Disruption of the RNA exosome reveals the hidden face of the malaria parasite transcriptome. RNA Biology. 2018;15(9):1206-1214. Zhang Q*, Siegel TN, Martins RM, Wang F, Cao J, Gao Q, Cheng X, Jiang L, Hon CC, Scheidig-Benatar C, Sakamoto H, Turner L, Jensen AT, Claes A, Guizetti J, Malmquist NA, Scherf A*. Exonuclease-mediated degradation of nascent RNA silences genes linked to severe malaria. Nature. 2014，513(7518):431-5. Zhang Q, Huang Y, Zhang Y, Fang X, Claes A, Duchateau M, Namane A, Lopez-Rubio JJ, Pan W*, Scherf A*. A critical role of perinuclear filamentous actin in spatial repositioning and mutually exclusive expression of virulence genes in malaria parasites. Cell Host Microbe. 2011 Nov 17;10(5):451-63.