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个人简介

同济大学医学院干细胞与再生医学系副主任,附属东方医院再生医学研究所,课题组长,研究员,上海张江国家自主创新示范区干细胞转化医学产业基地-张江二期干细胞抗衰老项目执行负责人,脐带间充质干细胞治疗老年衰弱症临床试验执行负责人。兼任上海市衰老与退行性疾病学会理事、中国整形美容协会干细胞研究与应用分会理事和青年委员、上海市生物工程学会细胞治疗专委会委员。长期致力于干细胞的表观遗传学与衰老的研究。主持(或参与)国家自然科学基金4项,科技部 “干细胞及转化研究”重大研究计划2项,上海市科委重点项目1项, 相继在国际学术期刊 Nature、Cell Stem Cell、Cell 和Microbiome等发表研究论文。 教育经历 1999-2003 石河子大学 学士 2003-2006 石河子大学 硕士 2006-2010 同济大学 博士 2007-2009 美国加州大学河滨分校(UCR)联合培养博士 工作经历 2011-2014 同济大学医学院再生医学系 青年课题组长 2014-2019 同济大学医学院再生医学系/附属同济医院 青年课题组长 2019-至今 同济大学干细胞与再生医学系/附属东方医院再生医学研究所 课题组长 学术荣誉 2005 石河子大学科研创新奖 2006 新疆维吾尔自治区优秀硕士学位论文/石河子大学优秀硕士学位论文 2010 同济大学-Millipore生命科学奖-表观遗传之星 2011 新疆生产建设兵团科技进步二等奖(第4署名) 2011 同济大学优秀博士学位论文 2011 同济大学青年优秀人才培养计划 2012 同济大学青年英才-优青培育计划 2013 上海市研究生优秀成果(博士学位论文) 2014 同济大学医学院优秀教师 2014 上海市医学科技进步一等奖(第11署名)

研究领域

通过干细胞(间充质干细胞、神经干细胞)的表观遗传学机制研究衰老(人、猴子和小鼠)的发生、发展和与衰老相关的神经退行性疾病的致病机制。 重点关注:衰老与表观遗传学相关机制的研究,尤其是DNA甲基化(去甲基化)是如何影响衰老的发生;并且通过特有植物资源筛选抗衰老活性成份的转化研究,以及肠道微生物是如何与宿主相互作用,影响宿主衰老的机制。

近期论文

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Gao, J., Wang, H., Shen, J., Liu, X., Zhu, X., Huang, C., Li, G., Sun, Y., Liu, Z#., Sun, Y. E#., & Liu, H#. Mutual regulation between GDF11 and TET2 prevents senescence of mesenchymal stem cells. Journal of Cellular Physiology, 1-14. (2023). https://doi.org/10.1002/jcp.31132 Xiaoqi Zhu, Junyan Shen, Shengyu Feng, Ce Huang, Hao Wang, Fengjiao Huo & Hailiang Liu#. Akkermansia muciniphila, which is enriched in the gut microbiota by metformin, improves cognitive function in aged mice by reducing the proinflammatory cytokine interleukin-6. Microbiome. 11, 120 (2023). https://doi.org/10.1186/s40168-023-01567-1. Gong X, Shen H, Guo L, Huang C, Su T, Wang H, Feng S, Yang S, Huo F, Liu H, Zhu J, Zhu JK, Li H#, Liu H#. Glycyrrhizic acid inhibits myeloid differentiation of hematopoietic stem cells by binding S100 calcium binding protein A8 to improve cognition in aged mice. Immun Ageing. 2023 Mar 11;20(1):12. doi: 10.1186/s12979-023-00337-9. PMID: 36906583; PMCID: PMC10007777. Shengyu Feng, Liuling Guo, Hao Wang, Shanshan Yang, Hailiang Liu#. Bacterial PncA improves diet-induced NAFLD in mice by enabling the transition from nicotinamide to nicotinic acid. Commun Biol 6, 235 (2023). https://doi.org/10.1038/s42003-023-04613-8. Xue Gong*, Haitao Shen*, Liuling Guo, Ce Huang, Tingting Su, Hao Wang, Shengyu Feng, Shanshan Yang, Fenjiao Huo, Haifeng Liu, Jianbo Zhu, Jian-Kang Zhu, Hongbin Li#, Hailiang Liu#. Glycyrrhizic Acid Inhibits Myeloid Differentiation of Hematopoietic Stem Cells by binding S100 Calcium Binding Protein A8 to Improve Cognition in Aged Mice, 05 December 2022, PREPRINT (Version 1) available at Research Square [https://doi.org/10.21203/rs.3.rs-2324512/v1] Fengjiao Huo, Qing Liu, Hailiang Liu. Contribution of muscle satellite cells to sarcopenia. 2022, Frontiers in Physiology. 13:892749. doi: 10.3389/fphys.2022.892749 Feng, Shengyu and Huang, Ce and Guo, Liuling and Wang, Hao and Liu, Hailiang, A Novel Epithelial-Mesenchymal Transition-Related Gene Signature for Prognosis Prediction in Patients With Lung Adenocarcinoma. 2022. Heliyon. 8(2):e08713. Ce Huang, Shengyu Feng, Fengjiao Huo, Hailiang Liu. Effects of four antibiotics on the diversity of the intestinal microbiota.2022. Microbiology Spectrum. 10(2):e0190421 Li Guozhi, Xu Dengxian, Huang Gang, Bi Quan, Yang Mao, Shen Haitao, Liu Hailiang. Analysis of Whole-Transcriptome RNA-Seq Data Reveals the Involvement of Alternative Splicing in the Drought Response of Glycyrrhiza uralensis. 2022. Frontiers in Genetics. fgene.2022.885651. Quan Bi;Hua Yao;Fei Wang;Dajun He;Wenbin Xu;Shuangquan Xie;Xifeng Chen;Yuxia Li;Hailiang Liu;Haitao Shen;Hongbin Li. Integrative analysis of the pharmaceutical active ingredient and transcriptome of the aerial parts of Glycyrrhiza uralensis under salt stress reveals liquiritin accumulation via ABA-mediated signaling. 2022, Molecular Genetics and Genomics. 297(2):333-343. Aiping Cao, Ling Gao, Fei Wang, Xuechen Tong , Shuangquan Xie , Xifeng Chen , Tianxin Lu, Haitao Shen, Hailiang Liu, Xiang Jin, Hongbin Li. Expression profiling of the mitogen-activated protein kinase gene family reveals their diverse response pattern in two different salt-tolerant Glycyrrhiza species. 2022. Genes Genomics. doi: 10.1007/s13258-021-01216-7. Yao Hua, Wang Fei, Bi Quan, Liu Hailiang, Liu Li, Xiao Guanghui, Zhu Jianbo, Shen Haitao, Li Hongbin,Combined Analysis of Pharmaceutical Active Ingredients and Transcriptomes of Glycyrrhiza uralensis Under PEG6000-Induced Drought Stress Revealed Glycyrrhizic Acid and Flavonoids Accumulation via JA-Mediated Signaling. 2022. Frontiers in Plant Science. DOI=10.3389/fpls.2022.920172. Ce Huang, Yingqian Zhu, Fengjiao Huo, Shengyu Feng, Xue Gong, Hua Jiang, Zhongmin Liu, Hailiang Liu. Models for Evaluation of Biological Age Based on Multi-omics. bioRxiv 2021.12.13.472382; doi: https://doi.org/10.1101/2021.12.13.472382 (Preprint) Shengyu Feng, Liuling Guo, Hailiang Liu. PncA from bacteria improves diet-induced NAFLD by enabling the transition from NAM to NA in mice. bioRxiv 2021.12.04.471202; doi: https://doi.org/10.1101/2021.12.04.471202 (Preprint) Wu Y, Wang H, Zhu J, Shen H, Liu H. Licochalcone A activation of glycolysis pathway has an anti-aging effect on human adipose stem cells. Aging. 2021 Dec 3;13(undefined). doi: 10.18632/aging.203734. Epub ahead of print. PMID: 34862330. Liu, Hailiang and Zhu, Xiaoqi and Gu, Qi and Wang, Hao and Liu, Xiaojing and Zhao, Enfeng and Liu, Xianjun and Shen, Junyan and Qin, Binglian and Zhang, Hui and Gao, Jiaming and Zhang, Kunshan and Quan, Wenqiang and Ruan, Qingwei and Fu, Lei and Lin, Quan and Li, Dong and Liu, Jie and Ge, Weihong and Shen, Haitao and Yu, Zhuowei and Sun, Yi Eve, GDF11 Rejuvenates Neural Stem Cells Via Smad2/3-PI3K-AKT-mTOR and Reverses Aged-Dependent Cognitive Decline. Available at SSRN: https://ssrn.com/abstract=3552151 (Preprint) Feng, Shengyu and Huang, Ce and Guo, Liuling and Wang, Hao and Liu, Hailiang, A Novel Epithelial-Mesenchymal Transition-Related Gene Signature for Prognosis Prediction in Patients With Lung Adenocarcinoma. Available at SSRN: https://ssrn.com/abstract=3889964 (Preprint) Ce Huang, Shengyu Feng, Fengjiao Huo, Hailiang Liu. Effects of four antibiotics on the diversity of the intestinal microbiota. bioRxiv doi: https://doi.org/10.1101/2021.07.19.453004 (Preprint). Zhu, Y., Ge, J., Huang, C., Liu, H(共同通讯)., Jiang, H. Application of mesenchymal stem cell therapy for aging frailty: From mechanisms to therapeutics. Theranostics,11(12):5675-5685 Wu, Y., Zhu, J., Liu, H., Liu, H. Licochalcone A improves the cognitive ability of mice by regulating Tand B-cell proliferation. Aging,13(6)8895-8915 Zhao, Y., Lu, H., Wang, Q., Liu, H., Shen, H., Xu, W., Ge, J., He, D. Rapid qualitative profiling and quantitative analysis of phenolics in Ribes meyeri leaves and their antioxidant and antidiabetic activities by HPLC-QTOF-MS/MS and UHPLC-MS/MS. Journal of Separation Science,44(7):1404-1420 Shen, J., Zhu, X., Liu, H. MiR-483 induces senescence of human adipose-derived mesenchymal stem cells through IGF1 inhibition. Aging, 12(15)15756-15770 Li, J., Xia, W., Zang, H., Dai, B., Zhang, Y., Feng, Y., Wang, A., Lin, Z., Liu, H(共同通讯)., Zhu, J. Expression analysis of aquaporin genes in Saussurea involucrata rosette leaves and functional analysis of upregulated SiPIP1;5A under low-temperature stress. Environmental and Experimental Botany,171,103958 Gao, J., Wu, Y., He, D., Zhu, X., Li, H., Liu, H., Liu, H. Anti-aging effects of Ribes meyeri anthocyanins on neural stem cells and aging mice. Aging, 12(17)17738-17753 Zhu, X., Shen, J., Feng, S., Huang, C., Liu, Z., Sun, Y.E., Liu, H. Metformin improves cognition of aged mice by promoting cerebral angiogenesis and neurogenesis. Aging, 12(18)17845-17862 Jiang, R., Gao, J., Shen, J., Zhu, X., Wang, H., Feng, S., Huang, C., Shen, H., Liu, H. Glycyrrhizic Acid Improves Cognitive Levels of Aging Mice by Regulating T/B Cell Proliferation. Frontiers in Aging Neuroscience,12,570116 Peng, Z., Gao, Q., Luo, C., Gong, W., Tang, S., Zhang, X., Song, W., Wang, Z., Liu, H(共同通讯)., Du, X., Liu, H. Flavonoid biosynthetic and starch and sucrose metabolic pathways are involved in the pigmentation of naturally brown-colored cotton fibers. Industrial Crops and Products,158,113045 Wang, H., Zhu, X., Shen, J., Zhao, E.-F., He, D., Shen, H., Liu, H (共同通讯)., Zhou, Y. Quantitative iTRAQ-based proteomic analysis of differentially expressed proteins in aging in human and monkey. BMC Genomics,20(1)725 Liu, H.-F., Luo, C., Song, W., Shen, H., Li, G., He, Z.-G., Chen, W.-G., Cao, Y.-Y., Huang, F., Tang, S.-W., Hong, P., Zhao, E.-F., Zhu, J., He, D., Wang, S., Huo, G.-Y., Liu, H. Flavonoid biosynthesis controls fiber color in naturally colored cotton. PeerJ,4:e4537

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