个人简介

Graham Murphy carries out research in organic chemistry. His research is based on the development of hypervalent iodine reagents. Whether it's developing new methods for carbene formation, C-C bond formation or α-carbonyl functionalization, hypervalent iodine is the key. He is using this chemistry to develop designer electrolytes for battery technologies and to target natural products. Organic synthesis Medicinal chemistry Synthetic methodology Hypervalent iodine Halogenation Faculty Association, University of Waterloo, Chemistry representative, 2011–present Chemistry Awards Committee, 2014–15 Science Faculty Council, Chemistry representative, 2012–14 Chemistry/Science Strategic Planning Initiative, Co-operative Education, 2012 Co-op strategic research panel, 2012 2001 BSc Chemistry, University of Victoria, BC 2006 PhD Organic Synthesis, University of Alberta, AB

研究领域

Given the prevalence of fluorine in pharmaceuticals (~20%), agrochemicals (~30%) and industrial chemicals (eg. Teflon®), new methods of incorporating fluorine into organic scaffolds is of utmost importance. Graham Murphy has recently discovered a new approach to incorporating fluorine and chlorine into organic materials, using hypervalent iodine reagents as halogen transfer agents. This chemistry holds broad appeal to a wide community, and is continuously being expanded to include structural scaffolds of industrial, medicinal and societal importance. Although lithium-ion batteries are the state-of-the-art rechargeable power source for portable electronics, achieving the same level of efficacy in large-scale systems (eg. hybrid electric vehicles) requires fundamental innovation in materials. Graham Murphy’s experience in target-oriented synthesis and in fluorination methodologies is being applied to devising new, oxidatively stable organic electrolytes for use in large-scale rechargeable batteries.

We like to play around with hypervalent iodine reagents. Whether it's developing new methods for carbene formation, or for a-carbonyl functionalization, hypervalent iodine is the key. We are using this chemistry in the development of designer electrolytes for battery technologies. And, should our newly-developed methods lend themselves to the synthesis of a natural product, we will gladly accept the challenge.

近期论文

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Kaivalya G. Kulkarni, Boris Miokovic, Matthew Sauder and Graham K. Murphy*, "Denitrogenative hydrofluorination of Aromatic Aldehyde Hydrazones Using (Difluoroiodo)toluene", Org. Biomol. Chem. 2016, accepted. DOI: 10.1039/C6OB02074G Geoffrey S. Sinclair, Richard Tran, Jason Tao, W. Scott Hopkins* and Graham K. Murphy*, “Borosilicate Activation of (Difluoroiodo)toluene in the gem-Difluorination of Phenyldiazoacetate Derivatives” Eur. J. Org. Chem. 2016, 27, 4603. (EurJOC Cover Art) Keith E. Coffey, Ryan Moreira, Farhana Z. Abbas and Graham K. Murphy, "Synthesis of 3,3-dichloroindolin-2-ones from Isatin-3-hydrazones and (Dichloroiodo)benzene” Org. Biomol. Chem. 2015, 3, 682. Graham K. Murphy*, Farhana Z. Abbas and Amy V. Poulton “α,α-Dichlorination of Oxindole Derivatives Using (Dichloroiodo)benzene” Adv. Synth. Cat., 2014, 356, 2919 Jason Tao, Richard Tran and Graham K. Murphy,* "Dihaloiodoarenes: a,a-Dihalogenation of Phenylacetate Derivatives," J. Am. Chem. Soc. 2013, 135 (44), pp 16312–16315. (Synfacts highlight in 2014)