刘树深 - 同济大学 - 环境科学与工程学院

个人简介

教育经历 1998~2001, 重庆大学生物工程学院，攻读博士学位 1986~1988, 中国科学院盐湖研究所，攻读硕士学位 1985~1986, 中国科学技术大学研究生院，攻读硕士学位工作经历 2006~至今，同济大学环境科学与工程学院/教授/博士生导师 2003~2006，南京大学环境学院教授、博士生导师(2004) 2001~2003，南京大学环境学院环境科学与工程博士后 1988~2001，桂林理工大学讲师(1990)/副教授(1994)/教授(1999) 科研项目国家自然科学基金面上项目(2020.01~2023.12), 个人护理品时间依赖Hormesis及在混合物中的传递规律与机理探索(21976139)，主持国家重点研发计划项目子课题(2018.12~2021.12)，混合污染物联合作用剂量-效应评价模型研究(2018YFC1603003-02)，负责十三五水体污染控制与治理重大专项子课题(2017-2020)，标准外污染物浓度限值研究(2017ZX07201005)，负责国家自然科学基金面上项目(2017~2020)，多元混合物合理有效表征及混合毒性预测模型研究(21677113)，主持国家自然科学基金重点项目(2015~2019)，土壤结合态农药的生物可利用性与潜在毒性(21437004)，骨干国家自然科学基金面上项目(2014~2017)，低剂量离子液体及相关混合物非单调剂量-效应曲线与分子机理研究(21377097)，主持高等学校博士学科点专项科研基金(2013~2015)，部分离子液体及其混合物产生低剂量刺激的时间依赖性与分子机制研究(20120072110052),主持国家自然科学基金面上项目(2012~2015)，非等效应非单调浓度-响应关系混合物通用浓度加和模型(21177097),主持国家自然科学基金面上项目(2010~2012)，基于效应分析的混合物整合加和预测模型研究 (20977065) ,主持十一五水体污染控制与治理重大专项子课题(2008-2011)，区域饮用水源特征污染物研究与风险综合评价(2008ZX07421-001)，负责国家自然科学基金面上项目(2008~2010)，含J型剂量效应谱的低剂量混合污染物毒性相互作用研究(20777056),主持国家高技术研究发展计划专题课题(2008~2010)，基于荧光素酶的混合污染物毒性测试技术(2007AA06Z417)，主持上海市重点基础研究项目(2006~2008)，低剂量混合POPs分析毒理与预测模型研究(06JC14067),主持国家自然科学基金面上项目(2006~2008)，对称三嗪污染混合物联合毒性及方法学研究(20577023)，主持广西新世纪十百千人才基金(2005~2007)，有机污染混合物毒性评价与分析方法学研究(2003208)，主持国家973项目骨干人员基金(2004~2008)，南京市大气气溶胶中持久性有机污染物污染特征及变化规律(2003CB415002)，负责国家优秀博士学位论文作者专项基金(2004~2008)，低剂量有机混合物毒性预测基础研究(200355)，主持广西高校学科带头人基金(2003~2006)，优化试验设计在混合有机污染物毒性评价中的应用，主持国家863项目子课题(2002~2005)，环境内分泌干扰物结构-剂量-效应三维模型 (2001AA646010-4)，负责广西自然科学基金项目(2002~2005)，三维分子电性距离矢量构建与环境内分泌干扰物活性相关(0236063)，主持中国博士后基金(2001~2003)，分子结构有效表征与EDCs活性相关研究，主持

研究领域

混合物计算毒理学方法、软件设计与应用化学混合物联合毒性评估与预测方法

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

Wang, Z. J.; Liu, S. S.*; Feng, L.; Xu, Y. Q. BNNmix: a new approach for predicting the mixture toxicity of multiple components based on the back-propagation neural network. Science of the Total Environment, 2020, 738: 140317. Xu, Y. Q.; Li, K.; Wang, Z. J.; Liu, S. S.*The weak magnetic field (WMF) enhances the stimulation of polymyxin B sulfate (POL) on Vibrio qinghaiensis sp.-Q67. Environmental Sciences Europe, 2020, 32(1): 11. Lu, B. Q.; Liu, S. S.*; Wang, Z. J.; Xu, Y. Q. Conlecs: A novel procedure for deriving the concentration limits of chemicals outside the criteria of human drinking water using existing criteria and species sensitivity distribution based on quantitative structure-activity relationship prediction. Journal of Hazardous Materials, 2020, 384, 121380. 郑乔峰, 居珍, 刘树深*. 敌敌畏及其代谢产物对青海弧菌和秀丽线虫的联合毒性. 化学学报, 2019, 77(10): 1008-1016. Qu, R.; Liu, S. S.*, Li, T.; Liu, H. L. Using an interpolation-based method (IDVequ) to predict the combined toxicities of hormetic ionic liquids. Chemosphere, 2019, 217, 669-679. Xu, Y. Q.; Liu, S. S.*; Wang, Z. J.; Li, K.; Qu, R. Commercial personal care product mixtures exhibit hormetic concentration-responses to Vibrio qinghaiensis sp.-Q67. Ecotoxicology and Environmental Safety, 2018, 162: 304-311. Wang, Z. J.; Liu, S. S.*; Ru, R. JSFit: a method for the fitting and prediction of J- and S-shaped concentration-response curves. RSC Advances, 2018, 8(12), 6572-6580. Li, T.; Liu, S. S.*; Ru, R.; Liu, H. L.. Global concentration additivity and prediction of the mixture toxicities: taking nitrobenzene derivatives as an example. Ecotoxicol. Environ. Saf. 2017, 144：475-481. Feng, L.; Liu, Liu, S. S.*; Li, K.; Tang, H. X.; Liu, H. L.*. The time-dependent synergism of the six-component mixtures of substituted phenols, pesticides and ionic liquids to Caenorhabditis elegans. J. Hazard. Mater. 2017, 327: 11-17. Liu, S. S.*; Li, Kai; Li, T.; Qu, R. Comments on "The synergistic toxicity of the multi chemical mixtures: Implications for risk assessment in the terrestrial environment". Environ. Int. 2016, 94: 396-398. Tang, H. X.; Liu, S. S.*; Li, K.; Feng, L. Combining the normalization with the uniform design-based ray procedure and combination index to investigate synergistic lethal toxicities of ternary mixtures on Caenorhabditis elegans. Anal. Meth. 2016, 8(22): 4466-4472. Liu, S. S.*; Xiao, Q. F.; Zhang, J.; Yu, M. Uniform design ray in the assessment of combined toxicities of multi-component mixtures. Sci. Bull. 2016, 61(1): 52-58. Chen, F.; Liu, S. S.*; Yu, M.; Qu, R.; Wang, M. C. Blocking the entrance of AMP pocket results in hormetic stimulation of imidazolium-based ionic liquids to firefly luciferase. Chemosphere 2015, 132: 108-113. Liu, L.; Liu, S. S.*; Yu, Mo; Chen, F. Application of the combination index integrated with confidence intervals to study the toxicological interactions of antibiotics and pesticides in Vibrio qinghaiensis sp.-Q67. Environ. Toxicol. Pharmacol. 2015, 39(1): 447-456. 陈浮; 刘树深*; 段欣甜. 青海弧菌荧光素酶蛋白三维分子结构的分子模拟研究. 化学学报, 2013, 71(7), 1035-1040. Zhang, J.; Liu, S. S.*; Yu, Z. Y.; Liu, H. L.; Zhang, J. The time-dependent hormetic effects of 1-alkyl-3-methylimidazolium chloride and their mixtures on Vibrio qinghaiensis sp. -Q67. J. Hazard. Mater. 2013, 258-259, 70-76. Zhu, X. W.; Liu, S. S.*; Qin, L. T.; Chen, F.; Liu, H. L. Modeling Non-monotonic Dose-effect Relationships: Model Evaluation and Hormetic Quantities Exploration. Ecotoxicol. Environ. Safety 2013, 89, 130-136. 刘树深*; 张瑾; 张亚辉; 覃礼堂. APTox: 化学混合物毒性评估与预测.化学学报, 2012, 70(14), 1511-1517. Dou, R. N.; Liu, S. S.*; Mo, L. Y.; Liu, H. L.; Deng, F. C. A novel direct equipartition ray design (EquRay) procedure for toxicity interaction between ionic liquid and dichlorvos. Environ. Sci. Pollut. Res. 2011, 18(5), 734-742. Ge, H. L.; Liu, S. S.*; Zhu, X. W.; Liu, H. L.; Wang, L. J. Predicting Hormetic Effects of Ionic Liquid Mixtures on Luciferase Activity Using the Concentration Addition Model. Environ. Sci. Technol. 2011, 45(4), 1623-1629. Qin, L. T.; Liu, S. S.*; Zhang, J.; Xiao, Q. F. A novel model integrated concentration addition with independent action for the prediction of toxicity of multi-component mixture. Toxicology 2011, 280(3), 164-172. Zhang, Jin; Liu, S. S.*; Dou, R. N.; Liu, H. L.; Zhang, J. Evaluation on the toxicity of ionic liquid mixture with antagonism and synergism to Vibrio qinghaiensis sp.-Q67. Chemosphere 2011, 82(7), 1024-1029. Zhang, Y. H.; Liu, S. S.*; Liu, H. L.; Liu, Z. T. Evaluation of the combined toxicity of 15 pesticides by uniform design. Pest Manag. Sci. 2010, 66(8), 879-887. Qin, L. T.; Liu, S. S.*; Liu, H. L.; Zhang, Y. H. Support vector regression and least squares support vector regression for hormetic dose-response curves fitting. Chemosphere 2010, 78(3), 327-334. Liu, S. S.*, Song, X. Q.; Liu, H. L.; Zhang, Y. H.; Zhang, J. Combined photobacterium toxicity of herbicide mixtures containing one insecticide. Chemosphere 2009, 75(3), 381-388. Zhu, X. W.; Liu, S. S.*, Ge, H. L.; Liu, Yan. Comparison between the Short-Term and the Long-Term Toxicity of Six Triazine Herbicides on Photobacteria Q67. Water Res. 2009, 43(6), 1731-1739. 朱祥伟, 刘树深*, 葛会林, 刘堰. 剂量-效应关系两种置信区间的比较. 中国环境科学, 2009, 29(2), 113-117. Zhang, Y. H.; Liu, S. S.*; Song, X. Q.; Ge, H. L. Prediction for the mixture toxicity of six organophosphorus pesticides to the luminescent bacterium Q67. Ecotoxicol. Environ. Safety 2008, 71(3), 880-888. Qin, L. T.; Liu, S. S.*; Liu, H. L.; Ge, H. L. A new predictive model for the bioconcentration factors of polychlorinated biphenyls (PCBs) based on the molecular electronegativity distance vector (MEDV). Chemosphere 2008, 70(9), 1577-1587. Liu, S. S.; Liu, H. L.; Yin, C. S.; Wang, L. S. VSMP: A Novel Variable Selection and Modeling Method based on the Prediction. J. Chem. Inf. Comput. Sci. 2003, 43(3), 964-969. Liu, S. S.; Yin, C. S.; Cai, S. X.; Li, Z. L. Molecular structural vector description and retention index of polycyclic aromatic hydrocarbons. Chemom. Intell. Lab. Syst. 2002, 61, 3-15. Liu, S. S.; Yin, C. S.; Wang, L. S. Combined MEDV-GA-MLR Method for QSAR of Three Panels of Steroids, Dipeptides, and COX-2 Inhibitors. J. Chem. Inf. Comput. Sci. 2002, 42(3), 749-756. Liu, S. S.; Yin, C. S.; Cai, S. X.; Li, Z. L. QSAR Study of Steroid Benchmark and Dipeptides Based on MEDV-13. J. Chem. Inf. Comput. Sci. 2001, 41(2), 321-329. Liu, S. S.; Liu, H. L.; Yu, B. M.; Cao, C. Z.; Li, Z. L. Investigation on Quantitative Relationship between Chemical Shift of Carbon-13 Nuclear Magnetic Resonance Spectra and Molecular Topological Structure Based on a Novel Atomic Distance-Edge Vector (ADEV). J. Chemom. 2001, 15(5), 427-438. Liu, S. S.; Cai, S. X.; Cao, C. Z.; Li, Z. L. Molecular Electronegative Distance Vector (MEDV) Relating to 15 Properties of Alkanes. J. Chem. Inf. Comput. Sci. 2000, 40(6), 1337-1348. 刘树深, 刘堰, 李志良, 蔡绍皙. 一个新的分子电性距离矢量(MEDV). 化学学报 2000, 58(11), 1353-1357. Liu, S. S.; Liu, H. L.; Xia, Z. N.; Cao, C. Z.; Li, Z. L. Molecular Distance-Edge Vector (μ): An Extension from Alkanes to Alcohols. J. Chem. Inf. Comput. Sci., 1999, 39(6), 951-957. Liu, S. S.; Cao, C. Z.; Li, Z. L. Approach to Estimation and Prediction for Normal Boiling Point (NBP) of Alkanes Based on a Novel Molecular Distance-Edge (MDE) Vector, l. J. Chem. Inf. Comput. Sci., 1998, 38(3), 387-394.