个人简介

Michael Chong's research is focused on developing new methodology for organic synthesis. This involves creating new reagents to carry out transformations which are not currently possible using existing methodology or to improve upon known reagents. Synthetic organic chemistry Development of new methods for stereoselective synthesis Carbon–carbon bond forming reactions New chiral ligands Organometallic reagents Insect pheromones Executive Committee member, 2013-present Chem 13 News Editorial Board Member, 2005-16 Science Open House Chemistry Magic Show Coordinator, 1996-2015 Science Faculty Council – chemistry representative, 2009-11 Associate Graduate Officer/Chemistry 794 coordinator, 2005-11 Canadian Society for Chemistry Accreditation Board member, 2007-10 Director, (GWC)2, 2006-09 Ontario Council on Graduate Studies external consultant, 2009 1983 PhD Synthetic Organic Chemistry, University of British Columbia 1979 BSc Honours Chemistry and Biochemistry, University of British Columbia

研究领域

Much of what Michael Chong's research team does is related to the preparation of compounds with defined stereochemistry. This can involve asymmetric synthesis, the use of enantiomerically-pure starting materials or resolutions. Stereochemistry is particularly important when dealing with biologically active materials such as pharmaceuticals and agrochemicals where apparently small changes can have major effects. Organometallic reagents play a major role in their research. Organometallic reagents are particularly useful in organic synthesis since they can be used to make new carbon-carbon bonds, often with stereochemical consequences. They have used organic derivatives of aluminum, boron, copper, lithium, magnesium, tin, and zinc to effect asymmetric transformations. While a wide range of metals is used, the underlying theme is the same: to make new carbon-carbon bonds with control of stereochemistry.

We are primarily interested in developing new methodology for organic synthesis. The focus of our work is on creating new reagents to carry out transformations which are not currently possible using existing methodology or to improve upon known reagents. Much of what we do is related to the preparation of compounds with defined stereochemistry. This can involve asymmetric synthesis, the use of enantiomerically-pure starting materials or resolutions. Stereochemistry is particularly important when dealing with biologically active materials such as pharmaceuticals and agrochemicals where apparently small changes can have major effects. Organometallic reagents play a major role in our research. Organometallic reagents are particularly useful in organic synthesis since they can be used to make new carbon-carbon bonds, often with stereochemical consequences. We have used organic derivatives of aluminum, boron, copper, lithium, magnesium, tin, and zinc to effect asymmetric transformations. While a wide range of metals is used, the underlying theme is the same: to make new carbon-carbon bonds with control of stereochemistry. Some specific examples are noted below.

近期论文

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Chemical Modification of Polyisobutylene Succinimide Dispersants and Characterization of Their Associative Properties. S. Pirouz, Y. Wang, J. M. Chong, and J. Duhamel, J. Phys. Chem B, 119, 12202-12211 (2015) Synthesis of E-Vinyl Iodides via Hydrostannation of Terminal Alkynes. A. Darwish and J. M. Chong, Tetrahedron, 68, 654-658 (2012) Binaphthol-Catalyzed Asymmetric Conjugate Arylboration of Enones.H. M. Turner, J. Patel, N. Niljianskul and J. M. Chong, Org. Lett, 13, 5796-5799 (2011) Selective Adsorption and Thermal Evolution of Bifunctional Carboxylic Acids: Competition of O-H Dissociation and other Reaction Products in Acrylic Acid and Propanoic Acid on Si(100)2×1., M. Ebrahimi; M. Chong, K. T. Leung, J. Phys. Chem. C, 114, 2947-2957 (2010). The Use of Phosphine Ligands to Control the Regiochemistry of Pd-Catalyzed Hydrostannations of 1-Alkynes: Synthesis of E-1-Tributylstannyl-1-alkenes.A. Darwish, A. Lang, T. Kim and J. M. Chong, Org. Lett, 10, 861-864 (2008)