个人简介

John Honek's research seeks to understand the fundamental interactions of small molecules (such as substrates and drugs) with enzymes as well as the mechanisms by which enzymes catalyze reactions. His research in this area includes mechanistic enzymology, recombinant DNA and biophysical methods as well as organic synthesis, medicinal chemistry and molecular modeling. An additional focus is in the area of bionanotechnology and the application of biological chemistry to the synthesis of new nanomaterials and nanostructures. Bionanomaterials Medicinal chemistry Enzymology Bioorganic chemistry Protein structure and function Associate Member, Synthesis Sub-committee IUPAC Organic and Biomolecular Division III, 2013-present Consulting for 4th year nanoengineering and Velocity Science research project students that included input on their potential research projects, as well as potential student spinoff companies, 2013-present Board of Directors, Centre for Bioengineering & Biotechnology, UW, 2013-2016 Scientific Advisory Board, Stem Cell & Cancer Research Institute (SCC-RI), McMaster University, 2012-2016 Scientific Advisory Committee, Ontario Consortium for Regeneration Inducing Therapeutics (OCRiT), 2011-2016 (GWC)2 Coordinating Committee, 1998-2014 Chair, Department of Chemistry, University of Waterloo, 2007-14 Nanotechnology Engineering Program Executive Board, 2007-14 Chemistry Department and Nano Executive Committees, 2007-14 Senate Honorary Degree Committee, 2009-10 Executive Committee, Board of Governors, University of Waterloo, 2009-10 1984 Ph.D. Organic Medicinal Chemistry, McGill University, QC 1977 B.Sc. Honours Chemistry, McGill University, QC

研究领域

John Honek's group works at the interface of chemistry and biochemistry. They apply chemical and biochemical principles and techniques to the problems of protein structure/function as well as to elucidate the chemical mechanisms of several key enzymes, some of which have medical importance. Organic chemistry (organic synthesis of novel biophysical probes and enzyme inhibitors and protein chemical modification techniques), physical chemistry and molecular modeling are being applied to complex protein structures. His group makes use of biochemical techniques such as recombinant DNA methodologies (PCR, site-directed mutagenesis, protein engineering, etc), microbiology (for protein expression) and protein purification.

Our interest is to understand the fundamental interactions of small molecules (such as substrates and drugs) with enzymes as well as the mechanisms by which enzymes catalyze reactions. Research in this area includes mechanistic enzymology, recombinant DNA and biophysical methods as well as organic synthesis, medicinal chemistry and molecular modeling. An additional focus is in the area of bionanotechnology and the application of biological chemistry to the synthesis of new nanomaterials and nanostructures.

近期论文

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J. F. Honek (2015) Glyoxalase Biochemistry. Biomolecular Concepts, 6, 401-414 (INVITED) C. L. Myers, E. G. Kuiper, P. C. Grant, J. Hernandez, G. L. Conn, and J. F. Honek (2015) Functional Roles in S-Adenosyl-L-Methionine Binding and Catalysis for Active Site Residues of the Thiostrepton Resistance Methyltransferase. FEBS Letters, 589, 3263-3270 J. F. Honek (2015) Biological Chemistry of the Carbon-Sulfur Bond. Canadian Journal of Chemistry, 93, 1051-1060 (INVITED) Suttisansanee, U., Ran, Y., Mullings, K. Y., Sukdeo, N., and John F. Honek (2015) Modulating Glyoxalase I Metal Selectivity by Deletional Mutagenesis: Underlying Structural Factors Contributing to Nickel Activation Profiles, Metallomics, 7, 605-612 (INVITED) Bythell-Douglas, R., Suttisansanee, U., Flematti, G. R., Challenor, M., Lee, M., Panjikar, S., Honek J. F. and Bond C. S. (2015) The Crystal Structure of a Homodimeric Pseudomonas Glyoxalase I Enzyme Reveals Asymmetric Metallation Commensurate with Half-of-Sites Activity. Chemistry - A European Journal, 21, 541-544