个人简介

Susan Mikkelsen's experimental research has involved the selectivity aspect of bioanalytical assays and sensors to overcome interferences that exist in biological or environmental samples. Her research program has investigated both natural and biomimetic recognition methods in an effort to distinguish and quantitate the analyte species in the presence of closely-related, potentially interfering species. Since closing her experimental laboratory in 2014, she now focuses on the preparation and writing of scholarly review articles, book chapters and entire books in the areas of bioanalytical and electroanalytical chemistry. Molecular and Biomolecular Recognition for Selective Analytical Sensors and Assays Electroanalytical Methods for the Sensitive Detection of Biomolecular Analytes Novel Recognition Mechanisms and Agents for Chemical Sensors, Biosensors and Bioassays Associate Graduate Officer (Main duty is Chem 794), 2012-present Member, USRA Evaluation/Recommendation Committee, 2012-present Faculty of Science Task Force “Communication for Scientists Training Initiative”, 2015 Chair, Strategic Planning Subcommittee (Entrepreneurship), 2012 Oral presentation judge at SOUSCC, Biological and Medicinal Chem. Session, 2011 Executive Committee, 2009-10 NCMDD Proposal Committee (Nat. Ctr. for Med. Device Development), 2008-09 1988 Ph.D. Analytical Chemistry, McGill University, QC 1982 B.Sc., University of British Columbia, BC

研究领域

Modern analytical instrumentation allows the analysis of solutions so dilute that single molecules can be detected, provided that no interfering species are present. Susan Mikkelsen's research has involved the selectivity aspect of analytical assays and sensors to overcome interferences that exist in such matrices as biological or environmental samples. Her research program has investigated both natural and biomimetic recognition methods in an effort to distinguish the analyte species from closely-related potential interferents. Analytes range in size from small molecules, like glucose or cysteine, to intact, viable microorganisms. Natural recognition has exploited enzymes, antibodies, lectins or chemoreceptors either as bioassay reagents or, once immobilized on a transducer surface, as the biorecognition components of biosensors. Biomimetic recognition has included the use of computational pattern recognition methods to selectively recognize the analyte. Her research has led to global collaborations, in Europe, South America and Asia. She currently collaborates with an experimental colleague in Argentina, who has also coauthored a recent textbook. Her new focus involves summarizing and condensing the scholarly literature, through the publication of focused review articles, book chapters and textbooks.

Our research involves the selectivity aspect of analytical assays and sensors to overcome interference that exist in such matrices as biological or environmental samples. Our research program investigates both natural and artificial recognition methods in an effort to distinguish the analyte species from closely-related potential interferants.

近期论文

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E. Corton and S. R. Mikkelsen, “Electrochemical Arrays for Bioassay Applications,” in Bioanalytical Reviews: Trends in Bioelectroanalysis, F.-M. Matysik, Ed., Springer, New York, 2016. Chapter 4. S. R. Mikkelsen and E. Corton, “Bioanalytical Chemistry,” Second Edition, 19 Chapters, 463 pp. including references, problems and answers. ISBN 9781118302545 (cloth) and 9781119057635 (epub). John Wiley & Sons Inc., New Jersey, 2016. M. Rahimi and S. R. Mikkelsen, “Cyclic Biamperometry at Micro-Interdigitated Electrodes,” Anal. Chem. 83, 2011, 7555-7559. Z. Qian, M. Khan, S. Mikkelsen and P. Chen, “Improved Enzyme Immobilization on an Ionic-Complementary-Peptide-Modified Electrode for Biomolecular Sensing,” Langmuir 26, 2010, 2176-2180. M. Rahimi and S. R. Mikkelsen, “Cyclic Biamperometry,” Anal. Chem. 82, 2010, 1779-1785. T. S. Mann, L. O’Hagan, P. Ertl, D. I. Sparkes and S. R. Mikkelsen, “Microplate-Compatible Biamperometry Array for Parallel 48-Channel Amperometric or Coulometric Measurements,” Anal. Chem. 80, 2008, 2988-2992.