王书宁 - 山东大学 - 微生物技术国家重点实验室

个人简介

教育背景博士起止时间：2000.9-2005.7毕业院校：山东大学专业：微生物学硕士起止时间：毕业院校：专业：学士起止时间：1996.9-2000.7毕业院校：山东大学专业：微生物学工作经历起止时间单位名称专业技术职务 2017.9至今山东大学教授 2007.9-2017.9 山东大学副教授 2005.7-2007.9 山东大学讲师 2008.7-2010.8 德国马普陆地微生物研究所（Rolf Thauer院士实验室）博士后 2011.4-2013.6 德国马普陆地微生物研究所（Rolf Thauer院士实验室）客座教授

研究领域

1. 厌氧微生物的生理代谢机制及其发酵应用 2. 环境污染物微生物降解的生化机制、资源化转化应用和环境修复 3. 高值化合物、平台化合物和生物能源的微生物发酵

近期论文

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1. Wang R.1, Yi J., Shang J.,Yu W., LiZ., Huang H., Xie H., Wang S*. (2019) 6-Hydroxypseudooxynicotine dehydrogenase delivers electrons to electron transfer flavoprotein during nicotine degradation byAgrobacterium tumefaciens S33. Appl. Environ. Microbiol. 85:e00454-19. 2. Liang J., Huang H.,Wang S*. (2019) Distribution, evolution, catalytic mechanism, and physiological functions of the flavin-based electron-bifurcating NADH-dependent reduced ferredoxin: NADP+ oxidoreductase.Front. Microbiol.10:373. 3. Yu W. 1, Wang R. 1, Li H., Liang J., Wang Y., Huang H., Xie H.,Wang S*. (2017) Green route to synthesis of valuable chemical 6-hydroxynicotine from nicotine in tobacco wastes using genetically engineeredAgrobacterium tumefaciens S33.Biotechnol. Biofuels. 10:288. 4. Yu W.1, Wang R., Huang H., Xie H.,Wang S*. (2017) Periplasmicnicotine dehydrogenase NdhAButilizespseudoazurin asitsphysiologicalelectron acceptor inAgrobacterium tumefaciens S33. Appl. Environ. Microbiol. 83(17):e01050-17. 5. Huang H.1, Yu W., Wang R., Li H., Xie H., Wang S*. (2017) Genomic and transcriptomic analyses of Agrobacterium tumefaciens S33 reveal the molecular mechanism of a novel hybrid nicotine-degrading pathway. Sci. Rep. 7(1):4813. 6. Li H.1, Xie K.1, Yu W., Hu L., Huang H., Xie, H., Wang S*. (2016) Nicotine dehydrogenase complexed with 6-hydroxypseudooxynicotine oxidase involved in the hybrid nicotine-degrading pathway in Agrobacterium tumefaciens S33. Appl. Environ. Microbiol. 82(6): 1745–1755. 7. Yu W. 1, Li H., Xie K., Huang H., Xie, H.,Wang S*. (2016) Genome sequence of the nicotine-degrading Agrobacterium tumefaciens S33. J. Biotechnol. 228:1-2. 8. Hu L.1, Huang H.1, Yuan H., Tao F., Xie H.,Wang S*. (2016) Rex inClostridium kluyveri is a global redox-sensing transcriptional regulator.J. Biotechnol.233:17-25. 9. Huang H.1, Hu L., Yu W., Li H., Tao F., Xie H.,Wang S*. (2016) Heterologous overproduction of 2[4Fe4S]- and [2Fe2S]-type clostridial ferredoxins and [2Fe2S]-type agrobacterial ferredoxin.Protein Expres. Purif. 121:1-8. 10. Demmer J. K.1, Huang H.1, Wang S., Demmer U., Thauer R. K.*, and Ermler U*. (2015) Insights intoflavin-basedelectronbifurcation via the NADH- dependentreducedferredoxin: NADP oxidoreductasestructure. J. Biol. Chem. 290(36): 21985-21995. 11. Li H.1, Xie K.1, Huang H.,Wang S*. (2014) 6-Hydroxy-3-succinoylpyridinehydroxylasecatalyzes acentralstep ofnicotinedegradation inAgrobacterium tumefaciens S33.PLoS ONE 9(7): e103324. 12. Mock J. 1,Wang S., Huang H., Kahnt J., Thauer R.K*. (2014) Evidence for ahexaheteromericmethylenetetrahydrofolatereductase inMoorella thermoacetica.J. Bacteriol. 196:3303-3314 13. Wang, S.1, Huang, H., Kahnt, J., Mueller, A., Köpke, M, Thauer, R. K*. (2013) NADP-specific electron-bifurcating[FeFe]-hydrogenase in a functional complex with formate dehydrogenase inClostridium autoethanogenum grown on CO.J. Bacterial. 195:4373-4386 14. Wang S.1, Huang, H., Kahnt, J., Thauer, R. K*. (2013)Clostridium acidurici electron-bifurcating formate dehydrogenase. Appl. Environ. Microbiol. 79: 6176-6179. 15. Wang S.1, Huang H.1, Kahnt J., Thauer R. K*. (2013) A reversible electron-bifurcating ferredoxin- and NAD-dependent [FeFe]-hydrogenase (HydABC) inMoorella thermoacetica.J. Bacteriol. 195:1267-1275.（并列第一作者） 16. Huang H.1,Wang S.1, Moll J., Thauer R. K*. (2012) Electron bifurcation involved in the energy metabolism of the acetogenic bacteriumMoorella thermoacetica growing on glucose or H2 plus CO2.J. Bacteriol. 194:3689-3699.（并列第一作者） 17. Wang S.1*, Huang H.,Xie K., Xu P*. (2012)Identification of nicotine biotransformation intermediates byAgrobacterium tumefaciens strain S33 suggests a novel nicotine degradation pathway.Appl. Microbiol. Biotechnol. 95:1567-1578. 18. Wang S.1, Huang H.1, Moll J., Thauer R. K*. (2010) NADP+ reduction with reduced ferredoxin and NADP+ reduction with NADH are coupled via an electron-bifurcating enzyme complex inClostridium kluyveri. J. Bacteriol. 192: 5115-5123.（并列第一作者） 19. Wang S. N.1, Liu Z., Xu P*. (2009) Biodegradation of nicotine by a newly isolatedAgrobacterium sp. strain S33.J. Appl. Microbiol. 107: 838-847.