刘怀伟 - 山东大学 - 微生物技术国家重点实验室

个人简介

教育背景 2005-2010 毕业院校：山东大学专业：微生物 1996-2003毕业院校：山东师范大学专业：生物科学工作经历 1. 2020/9-至今，山东大学，微生物技术研究院，教授 2. 2015/6-2020/9，山东大学，生命科学学院，副研究员 3. 2014/1-2015/6，美国伊利诺伊大学香槟分校，生物工程学院，博士后 4. 2011/4-2013/12，韩国明知大学，能源与环境融合技术中心，博士后

研究领域

微生物生理生化、微生物合成生物学 1. 微生物硫代谢及生理功能：硫化氢（H2S）被称为继CO和NO之后的第三个气体信号分子，参与抗氧化、蛋白翻译后修饰、调节细胞周期等多种生理功能，但其作用机制尚不清晰。通过构建胞内探针、研究基于HPLC和光谱学的检测方法等开发了一系列硫化物的追踪、定量技术，并对硫化物参与的蛋白修饰介导的信号传递及基因调控过程进行了研究 2. 合成生物学：首次将群体感应型基因线路用于代谢途径的调控，构建了基于菌体生长自动调控的二阶段发酵大肠杆菌细胞工厂

近期论文

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Fan, K; Chen, Z;Liu, H*. Evidence that the ProPerDP method is inadequate for protein persulfidation detection due to lack of specificity.Science Advances, 2020, DOI：10.1126/sciadv.abb6477. Hou N, Yan Z, Fan K, Li H, Zhao R, Xia Y, Xun L*,Liu H*. OxyR senses sulfane sulfur and activates the genes for its removal inEscherichia coli.Redox Biol. 2019, 26:101293. Liu H, Fan K, Li H, Wang Q, Yang Y, Li K, Xia Y*, Xun L*. Synthetic Gene Circuits Enable Escherichia coli To Use Endogenous H2S as a Signaling Molecule for Quorum Sensing.ACS Synth Biol. 2019. doi: 10.1021/acssynbio.9b00210. Liu H, Wang Q, Li H, Xun L*. Response on "commentary on "using resonance synchronous spectroscopy to characterize the reactivity and electrophilicity of biologically relevant sulfane sulfur". Evidence that the methodology is inadequate because it only measures unspecific light scattering". The evidence is incorrect.Redox Biol. 2019. doi: 10.1016/j.redox.2019.101312. Li H,Liu H*, Chen Z, Zhao R, Wang Q, Ran M, Xia Y, Hu X, Liu J, Xian M, Xun L*. Using resonance synchronous spectroscopy to characterize the reactivity and electrophilicity of biologically relevant sulfane sulfur.Redox Biol. 2019, 24:101179. doi: 10.1016/j.redox.2019 Hu X, Li H, Zhang X, Chen Z, Zhao R, Hou N, Liu J, Xun L,Liu H*. Developing Polysulfide-Sensitive GFPs for Real-Time Analysis of Polysulfides in Live Cells and Subcellular Organelles.Anal Chem. 2019 91(6):3893-3901. Li H, Li J, Lü C, Xia Y, Xin Y, Liu H, Xun L*,Liu H* (2017) FisR activates σ54 -dependent transcription of sulfide-oxidizing genes in Cupriavidus pinatubonensis JMP134.Mol Microbiol. doi: 10.1111/mmi.13725 Xin Y, Liu H, Cui F,Liu H, Xun L* (2016) RecombinantEscherichia coliwith sulfide:quinone oxidoreductase and persulfide dioxygenase rapidly oxidises sulfide to sulfite and thiosulfate via a new pathway.Environ Microbiol. 18(12):5123-5136. Liao C, Seo S, Celik V,Liu H, Kong W, Wang Y, Blaschek H, Jin Y, and Lu T* (2015) An integrated, systems metabolic picture of the acetone-butanol-ethanol fermentation byClostridium acetobutylicum.Proc. Natl. Acad. Sci. 112: 8505–8510. Liu H, Lu T* (2015) Autonomous production of 1,4-butanediol via a de novo biosynthesis pathway in engineeredEscherichia coli.Metab Eng. 29:135-41. Liu H, Wang Y, Tang Q, Kong W, Chung WJ, Lu T* (2014) MEP pathway-mediated isopentenol production in metabolically engineeredEscherichia coli.Microb Cell Fact. 13: 135.