佘群新 - 山东大学 - 微生物技术国家重点实验室

个人简介

教育背景博士 1988.10.－1992.10. 丹麦奥胡斯大学分子生物学硕士 1982.9.－1985.10. 中国南京农业大学农业微生物学本科 1978.9.－1982.7. 中国华中农业大学农业微生物学工作经历 2018.11.– 现在山东大学特聘教授 2011–现在丹麦哥本哈根大学古菌研究中心主任 2005–现在丹麦哥本哈根大学生物系终身副教授 2000–2004丹麦哥本哈根大学分子生物学研究院生物化学系科研副教授 1996–1999 丹麦哥本哈根大学分子生物学研究院生物化学系科研助理教授 1992–1995丹麦科技大学微生物研究中心博士后 1985–1988 中国农业科学院油料作物研究所（武汉）研究助理

研究领域

1. CRISPR/Cas防御体系的多样性和作用机理 2. 新型CRISPR技术的开发和利用：包括病毒和病原菌的检测，基因组编辑以及开发靶向CRIPSR基因治疗 3. 古菌病毒及其与宿主相互作用的分子机制 4. 古菌DNA复制机制和细胞周期的调控机理 5. 古菌DNA损伤应答及其介导的细胞程序性死亡分子机制

近期论文

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W. Han, S. Stella, Y. Zhang, T. Guo, K. Sulek, L. Lundgren, G. Montoya and Q. She*. 2018. A Type III-B Cmr effector complex catalyzes the synthesis of cyclic oligoadenylate second messengers by cooperative substrate binding. Nucleic Acids Res. 46, 10319-10330. M. Sun, X. Feng, Z. Liu, W. Han, Y. X. Liang*, and Q. She*. 2018. An Orc1/Cdc6 ortholog functions as a key regulator in the regulatory network of DNA damage response in an archaeon. Nucleic Acids Res. 46, 6697-6711. T. Guo, W. Han* and Q. She*. 2018. Tolerance of Sulfolobus SMV1 virus to the immunity of I-A and III-B CRISPR-Cas systems in Sulfolobus islandicus. RNA Biol. 2018 Jul 9:1-8. doi: 10.1080/15476286.2018.1460993. [Epub ahead of print] X. Feng, M. Sun, W. Han, Y. X. Liang, and Q. She*. 2018. A transcriptional factor B paralog functions as an activator to DNA damage-responsive expression in archaea. Nucleic Acids Res. 46, 7085-7096. T. Liu, S. Pan, Y. Li, N. Peng, Q. She. 2018. Type III CRISPR-Cas System: Introduction And Its Application for Genetic Manipulations. Curr Issues Mol Biol. 26, 1-14. doi: 10.21775/cimb.026.001. W. Han, S. Pan, B. López-Méndez, G. Montoya and Q. She*. 2017. Allosteric regulation of Csx1, a type IIIB-associated CARF domain ribonuclease by RNAs carrying a tetraadenylate tail. Nucleic Acids Res. 45, 10740-10750. Y. Li, Y. Zhang, J. Lin, S. Pan, W. Han, N. Peng, Y. X. Liang and Q. She*. 2017. Cmr1 enables efficient RNA and DNA interference of a III-B CRISPR-Cas system by binding to target RNA and crRNA. Nucleic Acids Res. 45, 11305-11314. T. Liu, Z. Liu, Q. Ye, S. Pan, X. Wang, W. Peng, Y. Li, X. Y. Liang, Q. She and N. Peng. 2017. Coupling transcriptional activation of CRISPR-Cas system and DNA repair genes by Csa3a in Sulfolobus islandicus. Nucleic Acids Res. 45, 8978-8992. D. Stiefler-Jensen, T. Schwarz-Linnet, C. de Lichtenberg, T. N. Nguyen, K. D. Rand, L. Huang, Q. She and K. Teilum. 2017. The extraordinary thermal stability of EstA from S. islandicus is independent of post translational modifications. Protein Sci. 26, 1819-1827. W. Han, Y. Xu, X. Feng, Y. X. Liang, L. Huang, Y. Shen. Q. She*. 2017. NQO-induced DNA-less cell formation is associated with chromatin protein degradation and dependent on A0A1-ATPase in Sulfolobus. Front Microbiol. doi:10.3389/fmicb.2017.01480 W. Han*, X. Feng, Q. She*. 2017. Reverse Gyrase Functions in Genome Integrity Maintenance by Protecting DNA Breaks In Vivo. Int J Mol Sci. 2017 Jun 22;18(7). pii: E1340. doi: 10.3390/ijms18071340. N. Peng, W. Han, Y. Li, Y. X. Liang and Q. She*. 2017. Genetic technologies for extremely thermophilic microorganisms of Sulfolobus, the only genetically tractable genus of crenarchaea. Sci China Life Sci. 60, 370-385. W. Han, L. Deng, M. Feng, W. Peng, S. Hallstrøm, Y. X. Liang, M. F. White, Q. She*. 2017. A type III-B CRISPR–Cas effector complex mediating massive target DNA destruction by modulating the cognate RNA cleavage. Nucleic Acids Res. 28, 1983-1993. V. Visone, W. Han, G. Perugino, G. del Monaco, Q. She, M. Rossi, A. Valenti, M. Ciaramella. 2017. In vivo and in vitro protein imaging in thermophilic archaea by exploiting a novel protein tag. PLoS One, 2017 Oct 3;12(10):e0185791. doi: 10.1371/journal.pone.0185791. Q. She*, X. Feng and W. Han. 2017. Archaeal DNA damage repair. In Communication of Archaea, (G. Witzany, ed. 2017) pp305-318. Springer Publisher C. Zhang C, Q. She, H. Bi, R. J. Whitaker. 2016. The apt/6-methylpurine counterselection system and its applications in genetic studies in the hyperthermophilic archaeon Sulfolobus islandicus. Appl Environ Microbiol. 82, 3070-81. J. Lin, Y. Zou, C. Ma, Y. X. Liang, X. Ge, Z. Chen, Q. She. 2016 Construction and characterization of three protein-targeting expression system in Lactobacillus casei. FEMS Microbiol. Lett. 2016 Apr;363(7). pii: fnw041. Y. Li, S. Pan, Y. Zhang, M. Ren, M. Feng, N. Peng, L. Chen, Y. X. Liang*, Q. She*. 2016. Harnessing Type I and Type III CRISPR-Cas systems for genome editing. Nucleic Acids Res. 44(4):e34. J. Lin, Y, Zou, C. Ma, Q. She, Y. X. Liang, Z. Chen, X. Ge. 2015. Heterologous Expression of Mannanase and Developing a New Reporter Gene System in Lactobacillus casei and Escherichia coli. PLoS One. 2015 Nov 12;10(11):e0142886. H. Wang, N. Peng, S. A. Shah, L. Huang*, Q. She*. 2015. Archaeal Extrachromosomal Genetic Elements. Microbiol. Mol. Biol. Rev. 79, 117-152. doi: 10.1128/MMBR.00042-14. W. Peng, M. Feng, X. Feng, X. Y. Liang, Q. She*. 2015. An archaeal CRISPR type III-B system exhibiting distinctive RNA targeting features and mediating dual RNA and DNA interference. Nucleic Acids Res. 43, 406-417. T. Liu, Y. Li, X. Wang, Q. Ye, H. Li, Y. X. Liang, Q. She, N. Peng. 2015. Transcriptional regulator-mediated activation of adaptation genes triggers CRISPR de novo spacer acquisition. Nucleic Acids Res. 43(2):1044-1055. S. Fusco S, Q. She, G. Fiorentino, S. Bartolucci, P. Contursi. 2015. Unravelling the role of the F55 regulator in the transition from lysogeny to UV induction of Sulfolobus spindle-shaped virus 1. J. Virol. 89, 6453-6461. S. Fusco, R. Liguori, D. Limauro, S. Bartolucci, Q. She*, P. Contursi*. 2015. Transcriptome analysis of Sulfolobus solfataricus infected with two related fuselloviruses reveals novel insights into the regulation of CRISPR-Cas system, Biochimie 118, 322-332.