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个人简介

教育背景 博士 起止时间:1983-1986毕业院校:山东大学 专业:微生物学 硕士 起止时间:1978-1981毕业院校:山东大学 专业:微生物学 学士 起止时间:1972-1974毕业院校:山东大学 专业:工业微生物学 工作经历 起止时间 单位名称 专业技术职务 1974.8-1978.8 山东济宁酿酒厂 技术员,技术科长 1981.10-1988.8 山东大学微生物研究所 助教、讲师 1988.8-1993.9 山东大学微生物研究所 副教授 1993.9-今 山东大学微生物研究所 教授、博导 1981.10-1982.9 日本大阪大学、 研修生 东京大学“国际微生物学研究班” 1993.12-1994.4 瑞典隆德大学化学中心应用微生物学系 访问学者 1998.10-1999.9 日本京都大学大学院应用生命科学专业 访问学者

研究领域

木质纤维素微生物降解转化技术

近期论文

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1. Purification and characterization of a novel cellobiohydrolase (PdCel6A) fromPenicillium decumbensJU-A10 for bioethanol production,Bioresource Technology, 2011, 102: 8339-8342. 2. N-Glycoform Diversity of Cellobiohydrolase I fromPenicillium decumbensand Synergism of Nonhydrolytic Glycoform in Cellulose Degradation, 2012,J Biol Chem, 287(19);15906–15915. 3. Ras GTPases Modulate Morphogenesis, Sporulation and Cellulase Gene Expression in the Cellulolytic FungusTrichoderma reesei, 2012,PLoS ONE, 7(11), e48786, 4. Improved cellulase production via disruption of PDE01641 in cellulolytic fungusPenicillium decumbens,Bioresource Technology123 (2012) 733–737. 5.Genomic and Secretomic Analyses Reveal Unique Features of the Lignocellulolytic Enzyme System ofPenicillium decumbens. 2013,PLoS ONE8(2): e55185. 6. Long-term strain improvements accumulate mutations in regulatory elements responsible for hyper-production of cellulolytic enzymes.Scientific Reports, 2013,3: 1569 | DOI: 10.1038/srep01569. 7. Development of highly efficient, low-cost lignocellulolytic enzyme systems in thepost-genomic era,Biotechnology Advances, 2013, 31 (6)962-975. 8. Promotion of extracellular lignocellulolytic enzymes production by restraining the intracellularβ-glucosidase in Penicillium decumbens,Bioresource Technology, 2013,137 (2013) 33-40 9.Penicillium deumbensBrlA extensively regulates secondary metabolism and functionally associates with the expression of cellulase genes.Appl Microbiol Biotechnol2013 Dec; 97(24):10453-67. 10. Cellodextrin transporters play important roles in cellulase induction in the cellulolytic fungusPenicillium oxalicum.Appl Microbiol Biotechnol. 2013 Dec; 97(24):10479-88. 11. Functional characterization of protein kinase CK2 regulatory subunit regulating Penicillium oxalicum asexual development and hydrolyticenzyme production,Fungal Genetics and Biology, 2014, 66: 44-53. 12.Redesigning the regulatory pathway to enhance cellulase production inPenicillium oxalicum.Biotechnol Biofuels,2015,8:71 doi:10.1186/s13068-015-0253-8. 13.Linker length and flexibility induces new cellobiohydrolase activity of PoCel6A from Penicillium oxalicum,Biotechnol. J. 2015, 10:899–904, DOI 10.1002/biot.201400734 14.Synergistic and Dose-controlled Regulation of Cellulase Gene Expression in Penicillium oxalicum.PLoS Genet,2015. DOI: 10.1371/journal.pgen.1005509. 15.Penicillium oxalicumPoFlbC regulates fungal asexual development and is important for cellulase gene expression.Fungal Genet Biol. 2015 Dec 23; 86: 91-102. 16. Proteomic analysis of the biomass hydrolytic potentials ofPenicillium oxalicumlignocellulolytic enzyme system.Biotechnol Biofuels, 2016, 9: 68. DOI 10.1186/s13068-016-0477-2. 17. Expression and chromatin structures of cellulolytic enzyme gene regulated by heterochromatin protein 1,Biotechnol Biofuels(2016) 9:206. 18. Production of a high-efficiency cellulase complex via β-glucosidase engineering inPenicillium oxalicum.Biotechnol Biofuels,2016,9:78, DOI 10.1186/s13068-016-0491-4.

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