王浩鑫 - 山东大学 - 微生物技术国家重点实验室

个人简介

工作经历起止时间单位名称专业技术职务 2016/9 -至今山东大学副教授 2010/6 –2016.8 山东大学讲师 2008/3 - 2010/3 厦门大学博士后

研究领域

1.放线菌与“不可培养”微生物中新天然产物的理性挖掘与生物合成研究2.基于生物合成/合成生物学的天然产物结构改造3.天然产物活性与功能研究

近期论文

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1.Y. Li,H. Wang, Y. Liu, Y. Jiao, S. Li, Y. Shen*, L. Du*(2018). "Biosynthesis of the Polycyclic System in the Antifungal HSAF and Analogues from Lysobacter enzymogenes" Angew Chem Int Ed Engl. accepted, DOI: 10.1002/anie.201802488. 2. G. Shi#; N. Shi#; Y. Li; W. Chen; J. Deng; C. Liu; J. Zhu;H. Wang*; Y. Shen*, d-Alanylation in the Assembly of Ansatrienin Side Chain is Catalyzed by a Modular NRPS. ACS chemical biology 2016, 11(4), 876-881. 3.S. Li; Y. Li; C. Lu; J. Zhang; J. Zhu;H. Wang*; Y. Shen*, Activating a Cryptic Ansamycin Biosynthetic Gene Cluster To Produce Three New Naphthalenic Octaketide Ansamycins with n-Pentyl and n-Butyl Side Chains. Org Lett 2015, 17, 3706-9. 4.C. Liu; J. Zhu; Y. Li; J. Zhang; C. Lu;H. Wang*; Y. Shen*, In Vitro Reconstitution of a PKS Pathway for the Biosynthesis of Galbonolides in Streptomyces sp. LZ35. Chembiochem 2015, 16, 998-1007. 5.C. Xie; J. Deng;H. Wang*, Identification of AstG1, A LAL family regulator that positively controls ansatrienins production in Streptomyces sp. XZQH13. Curr Microbiol 2015, 70, 859-64. 6.J. Zhu; W. Chen; Y. Li; J. Deng; D. Zhu; J. Duan; Y. Liu; G. Shi; C. Xie;H. Wang*; Y. Shen*, Identification and catalytic characterization of a nonribosomal peptide synthetase-like (NRPS-like) enzyme involved in the biosynthesis of echosides from Streptomyces sp. LZ35. Gene 2014, 546, 352-8. 7.S. Li#;H. Wang#; Y. Li; J. Deng; C. Lu; Y. Shen*, Biosynthesis of hygrocins, antitumor naphthoquinone ansamycins produced by Streptomyces sp. LZ35. Chembiochem 2014, 15, 94-102. 8.H. Wang; Y. Chen; L. Ge; T. Fang; J. Meng; Z. Liu; X. Fang; S. Ni; C. Lin; Y. Wu; M. Wang; N. Shi; H. He; K. Hong; Y. Shen, PCR screening reveals considerable unexploited biosynthetic potential of ansamycins and a mysterious family of AHBA-containing natural products in actinomycetes. J Appl Microbiol 2013, 115, 77-85. 9.C. Lu#; Y. Li#; J. Deng#; S. Li;H. Wang*; Y. Shen*, Hygrocins C-G, cytotoxic naphthoquinone ansamycins from gdmAI-disrupted Streptomyces sp. LZ35. J Nat Prod 2013, 76, 2175-2179. 10.Y. Jiang#;H. Wang#; C. Lu; Y. Ding; Y. Li; Y. Shen, Identification and characterization of the cuevaene A biosynthetic gene cluster in Streptomyces sp. LZ35. Chembiochem 2013, 14, 1468-1475. 11.H. Wang; Z. Geng; Y. Zeng; Y. Shen, Enriching plant microbiota for a metagenomic library construction. Environ Microbiol 2008, 10, 2684-2691