李盛英 - 山东大学 - 微生物技术国家重点实验室

个人简介

教育背景博士：2004.09-2009.12，美国密西根大学药学院，药物化学系硕士：2000.09-2003.07，厦门大学生命科学学院，微生物与生物技术系学士：1996.09-2000.07，厦门大学生命科学学院，生物学基地班工作经历起止时间单位名称专业技术职务 2018.11至今，微生物技术国家重点实验室，山东大学，教授 2012.06-2018.10，中国科学院青岛生物能源与过程研究所，研究员 2010.01-2012.05，美国密西根大学生命科学学院，博士后；参与创立生物技术公司Alluvium Biosciences Inc.，并担任生化部总监 2003.09-2004.08，厦门大学生命科学学院，研究助理

研究领域

1.微生物天然产物生物合成 2. P450酶学与酶工程 3.工业微生物菌株改良

近期论文

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Ye, Y. #, Du, L. #, Zhang, X.,Newmister, S. A.,McCauley, M.,Alegre-Requena, J. V., Zhang, W., Mu, S.,Minami, A.,Fraley, A. E.,Adrover-Castellano, M. L.,Carney, N. A., Shende, V. V., Qi, F.,Oikawa, H., Kato, H.,Tsukamoto, S., Paton, R. S.,Williams, R. M.*, Sherman, D. H.*, andLi, S.* Fungal-derived Brevianamide assembly by a stereoselective semi-pinacolase.Nat. Catal.(Accepted) Li, S.*, Du, L., and Bernhardt, R.* Redox partners: Function modulators of bacterial P450 enzymes.Trends Microbiol. 2020, doi.org/10.1016/j.tim.2020.02.012. Jiang, Y., Li, Z., Zheng, S., Xu, H., Zhou, Y. J., Gao, Z., Meng, C. *, andLi, S.* Establishing an enzyme cascade for one-pot production of α-olefns from low-cost triglycerides and oils without exogenous H2O2 addition.Biotechnol. Biofuels 2020, 13, 52. Xu, H., Liang, W., Ning, L., Jiang, Y., Yang, W., Wang, C., Qi, F., Ma, L., Du, L., Fourage, L., Zhou, Y. J. andLi, S.* Directed Evolution of P450 Fatty Acid Decarboxylases via High-Throughput Screening towards Improved Catalytic Activity.ChemCatChem 2019, 11, 1-6.. Liu, K., andLi, S.* Biosynthesis of fatty acid derived hydrocarbons: perspectives on enzymology and enzyme engineering,Curr. Opin. Biotech.2019, 62, 7-14. Zhang, W., Du, L., Qu, Z., Zhang, X., Li, F., Li, Z., Qi, F., Wang, X., Jiang, Y., Men, P., Sun, J., Cao, S., Geng, C., Qi, F., Wan, X., Liu, C., andLi, S.* Compartmentalized Biosynthesis of Mycophenolic Acid.Proc. Natl. Acad. Sci. U.S.A. 2019, 116(27), 13305-13310. Jiang, Y., Li, Z., Wang, C., Zhou, Y. J., Xu, H.*, andLi, S.*Biochemical characterization of three newα-olefn-producing P450 fatty acid decarboxylases with a halophilic property.Biotechnol. Biofuels 2019, 12, 79. Zhang, W. #, Du, L. #, Li, F., Zhang, X., Qu, Z., Han, L., Li, Z., Sun, J., Qi, F., Yao, Q., Sun, Y., Geng, C.,Li, S.* Mechanistic insights into interactions between bacterial class I P450 enzymes and redox partners.ACS Catal. 2018, 8, 9992-10003. Jiang, Y.,Li, S.* The catalytic function and application of cytochrome P450 enzymes in biosynthesis and organic synthesis.Chin. J. Org. Chem. 2018,38(9), 2307-2323. Qi, F. #, Lei, C. #, Li, F., Zhang, X., Wang, J., Zhang, W., Fan, Z., Li, W., Tang, G., Xiao, Y.*, Zhao, G.,Li, S. * Deciphering the late steps of rifamycin biosynthesis.Nat. Commun.2018, 9,2342. Chen, H., Meng, X., Xu, X., Liu, W.,Li, S. *The molecular basis for lipase stereoselectivity.Appl. Microbiol. Biotechnol. 2018,102(8),3487-3495. Xu, H., Ning, L., Yang, W., Fang, B., Wang, C., Wang, Y., Xu, J., Colin, S., Laeuffer, F., Fourage, L., andLi, S. * In vitrooxidative decarboxylation of free fatty acids to terminal alkenes by two new P450 peroxygenases.Biotechnol. Biofuels2017, 10,208. Zhang, X., andLi, S.* Expansion of chemical space for natural products by uncommon P450 reactions.Nat. Prod. Rep. 2017, 34(9), 1061-1089. Du, L. #, Dong, S. #, Zhang, X., Jiang, C., Chen, J., Yao, L., Wang, X., Wan, X., Liu, X., Wang, X., Huang, S., Cui, Q., Feng, Y. *, Liu, S.*, andLi, S.*Selective oxidation of aliphatic C–H bonds in alkylphenols by a chemomimetic biocatalytic system.Proc. Natl. Acad. Sci. U.S.A. 2017,114(26), E5129-E5137. Li, Z., Du, L., Zhang, W., Zhang, X., Jiang, Y., Liu, K., Men, P., Xu, H., Fortman, J. L., Sherman, D. H., Yu, B., Gao, S.,Li, S.* Complete elucidation of the late steps of bafilomycin bios ynthesis inStreptomyces lohii.J. Biol. Chem. 2017,292(17), 7095-7104. Fang, B. #, Xu, H. #, Liu, Y., Qi, F., Zhang, W., Chen, H., Wang, C., Wang, Y., Yang, W., andLi, S.* Mutagenesis and redox partners analysis of the P450 fatty acid decarboxylase OleTJE.Sci. Rep.2017, 7, 44258. Sun, Y. #, Ma, L. #, Han, D. #, Du, L., Qi, F., Zhang, W., Sun, J., Huang, S., Kim, E.-S.,* andLi, S.* In vitro reconstitution of the cyclosporine specific P450 hydroxylases using heterologous redox partner proteins. J. Ind. Microbiol. Biotechnol.2016, 44(2),161-166. Zhang, X., Li, Z., Du, L., Chlipala, G. E., Lopez, P. C., Zhang, W., Sherman, D. H.*, andLi, S.* Identification of an unexpected shunt pathway product provides new insights into tirandamycin biosynthesis.Tetrahedron Lett. 2016, 57(52), 5919-5923. Zheng, X., Fang, B., Han, D., Yang, W., Qi,F., Chen, H., andLi, S.* Improving the Secretory Expression of an α-Galactosidase fromAspergillus niger in Pichia pastoris.PLoS ONE 2016,11(8), e0161529. Du, L., Ma, L., Qi, F., Zheng, X., Jiang, C., Li, A., Wan, X., Liu, S.-J.*, andLi, S.* Characterization of a unique pathway for 4-cresol catabolism initiated by phosphorylation inCorynebacterium glutamicum. J. Biol. Chem. 2016, 291(12), 6583-6594.