汤亚杰 - 山东大学 - 微生物技术国家重点实验室

个人简介

汤亚杰，山东大学“微生物技术国家重点实验室”特聘教授、博士生导师。2003年于华东理工大学生物反应器工程国家重点实验室获生物化工博士学位，2005年从美国麻省理工学院(MIT)学成回国。

研究领域

1：天然药物生物智造 2：天然抗肿瘤新药创制

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

1.Wei Zhao1, Long He1, Tian-Le Xiang, and Ya-Jie Tang*. Discover 4β-NH-(6-aminoindole)-4-desoxy-podophyllotoxin with nanomolar-potency antitumor activity by improving the tubulin binding affinity on the basis of a potential binding site nearby colchicine domain. European Journal of Medicinal Chemistry 2019 (accepted) (1 with equal contribution to this work) 2.Qing-Yun Zhang1, Wei Zhao1, Ya-Jie Tang*. Discover the leading compound of 4β-S-(5-fluorobenzoxazole)-4-deoxy-4'-demethylepipodophyllotoxin with millimolar-potency toxicity by modifying the molecule structure of podophyllotoxin. European Journal of Medicinal Chemistry 2018, 158:951-964. (1 with equal contribution to this work) 3.Yang-Hua Xu1, Kai-Zhi Jia1, Ya-Jie Tang*. Regulatory networks governing methionine catabolism into volatile organic sulfur-containing compounds in Clonostachys rosea. Applied and Environmental Microbiology 2018, 84(22): e01840-18 (1 with equal contribution to this work) 4.Li-Wen Zhu, Ya-Jie Tang*. Current advances of succinate biosynthesis in metabolically engineered Escherichia coli. Biotechnology Advances 2017, 35:1040-1048. 5.Wei Zhao1, Chen Zhou1, Ze-Yuan Guan, Fu-Sheng Chen*, Ping Yin*, Ya-Jie Tang*. Structural insights into the inhibition of tubulin by the antitumor agent 4β-S-(1, 2, 4-triazole-3-yl)-podophyllotoxin. ACS Chemical Biology 2017, 12:746-752 (1 with equal contribution to this work) 6.Li-Na Wei1, Li-Wen Zhu1, Ya-Jie Tang*. Succinate production positively correlates with the affinity of the global transcription factor Cra for its effector FBP in Escherichia coli. Biotechnology for Biofuels 2016, 9:624. (1 with equal contribution to this work) 7.Jun-Han Yu1, Li-Wen Zhu1, Shi-Tao Xia1, Hong-Mei Li, Ya-Ling Tang, Xin-Hua Liang, Tao Chen, Ya-Jie Tang*. Combinatorial optimization of CO2 transport and fixation to improve succinate production by promoter engineering. Biotechnology and Bioengineering 2016, 113:1531-1541. (1 with equal contribution to this work) 8.Li Xiao1, Wei Zhao1, Hong-Mei Li, Duan-Ji Wan, Dong-Sheng Li, Tao Chen, Ya-Jie Tang*. Design and synthesis of the novel DNA topoisomerase II inhibitors: esterification and amination substituted 4′-demethylepipodophyllotoxin derivates with anti-tumor activity by activating ATM/ATR signaling pathways. European Journal of Medicinal Chemistry 2014, 80:267-277. (1 with equal contribution to this work) 9.Li-Wen Zhu1, Xiao-Hong Li1, Lei Zhang, Hong-Mei Li, Jian-Hua Liu, Zhan-Peng Yuan, Tao Chen, Ya-Jie Tang*. Activation of glyoxylate pathway without the activation of its related gene in succinate-producing engineered Escherichia coli. Metabolic Engineering 2013, 20:9-19. (1 with equal contribution to this work) 10.Ya-Jie Tang*, Wei Zhao, Hong-Mei Li. Novel tandem biotransformation process for the biosynthesis of a novel compound 4-(2, 3, 5, 6-tetramethylpyrazine-1)-4′-demethylepipodophyllotoxin. Applied and Environmental Microbiology 2011, 77:3023-3034.