艾德铭 - 山东大学 - 微生物技术国家重点实验室

个人简介

教育背景博士起止时间：1991-1994 毕业院校：巴黎第七大学专业：微生物学硕士起止时间：1988-1991 毕业院校：图宾根大学专业：生物学学士起止时间：1986-1988 毕业院校：图宾根大学专业：生物学工作经历起止时间单位名称专业技术职务 2015.01-至今山东大学特聘教授山东大学-亥姆霍兹生物技术研究所执行所长 2010.02-2015.06 中科科院上海巴斯德研究所所长/教授 2007.03-至今格里菲斯大学客座教授 2006.07-2009.06 CombinatoRx–Singapore 公司总裁 2003.06-2006.07 香港大学巴斯德研究中心首席执行官/科学主管/客座教授

研究领域

抗病毒感染研究、药物作用机理研究 1.重要病毒病（手足口病、人呼吸道合胞病毒感染等）的抗病毒药物的筛选和治疗策略开发； 2.重要病毒病病原的流行病学分析和毒株耐药性分析； 3.病毒感染的分子机制分析及药物新靶点的发现。

近期论文

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(1)P.Ren; Y.Zheng; W.Wang; L.Hong; F.Delpeyroux; F. Arenzana-Seisd;R.Altmeyer*. Suramin interacts with the positively charged region surrounding the 5-fold axis of the EV-A71 capsid and inhibits multiple enterovirus A, Scientific Reports, 2017.2.20, 2017(7): 1~11 (2)B. Bailly; C.-A. Richard; G. Sharma; L. Wang; L. Johansen; J. Cao; V. Pendharkar; D.-C. Sharma; M. Galloux; Y. Wang; R. Cui; G. Zou; P. Guillon; M. von Itzstein; J.-F. Eléouët*;R. Altmeyer*. Targeting human respiratory syncytial virus transcription antitermination factor M2-1 to inhibit in vivo viral replication, Scientific Reports, 2016.5.19, 2016(6): 1~11 (3)R.Cui ; Y.Wang ; L.Wang; G.Li ; Lan K;R.Altmeyer*; G.Zou *. Cyclopiazonic acid, an inhibitor of calcium-dependent ATPases with antiviral activity against human respiratory syncytial virus, Antiviral Research, 2016, 132: 38~45 (4)B.Bailly; L.Dirr ; IM.El-Deeb ;R.Altmeyer*;P.Guillon* ;M.von Itzstein*. A dual drug regimen synergistically blocks human parainfluenza virus infection, Scientific Reports, 2016, 6 (5)Y.Wang ; G.Li ; S.Yuan ;Q .Gao ; K.Lan ;R.Altmeyer *; G.Zou *. In Vitro Assessment of Combinations of Enterovirus Inhibitors against Enterovirus 71, Antimicrobial Agents and Chemotherapy, 2016, 60(9): 5357~5367 (6)Y.Wang; G.Zou ;A.Xia ;X.Wang ; J.Cai ; Q.Gao ; S.Yuan ; G.He ; S.Zhang ; M.Zeng*;R.Altmeyer *.Enterovirus 71 infection in children with hand, foot, and mouth disease in Shanghai, China: epidemiology, clinical feature and diagnosis,Virology Journal, 2015.6.3, 12(1): 83~89 (7)S.Yuan ; G.Li ; Y.Wang ; Q.Gao ; Y.Wang ; R.Cui ;R.Altmeyer *; G.Zou *. Identification of Positively Charged Residues in Enterovirus 71 Capsid Protein VP1 Essential for Production of Infectious Particles, Journal of Virology, 2015.10.28,90(2): 741~752 (8)Q.Gao; S.Yuan ; C.Zhang ; Y.Wang ; Y.Wang ; G.He ; S.Zhang ;R.Altmeyer *; G.Zou *. Discovery of Itraconazole with Broad-Spectrum In Vitro Antienterovirus Activity That Targets Nonstructural Protein 3A, Antimicrobial Agents and Chemotherapy, 2015, 59(5): 2654~2665 (9)P.Ren; G.Zou ; B.Bailly ;S.Xu ; M.Zeng; X.Chen ; L.Shen ; Y.Zhang ; P.Guillon;F.Arenzana-Seisdedos;P.Buchy;J.Li;M.vonItzstein ;Q .Li ;R.Altmeyer *. The approved prdiatric drug seramin identified as a clinicalcandidate for the tratment of EV71 infection-suramin inhibits EV71 infection in vitro and in vivo, Emerging Microbes and infections, 2014, 3(e62) (10)Y.Wang; Q.Zhu ; M.Zeng ;R.Altmeyer *; G.Zou *. Complete Genome Sequence of a Human Enterovirus 71 Strain Isolated from a Fatal Case in Shanghai, China, in 2012, Genome Announcements, 2014, 2(3): e0045714