赵小凡 - 山东大学 - 生命科学学院

个人简介

教育背景博士： 1996-1997 南京农业大学昆虫生理硕士： 1982-1984 山东大学动物学本科： 1978-1981 西南师范大学生物学工作经历 1984-1987 山东大学讲师 1987-1994 山东大学副教授 1994-1999 山东大学教授 2000-至今山东大学博导

研究领域

以棉铃虫为材料，用分子生物学方法研究昆虫蜕皮与变态的分子机理，包括：蜕皮激素信号转导途径、蜕皮与变态功能基因的表达与调控、变态发育中组织重建的分子机理、血细胞在变态发育中的功能等。

近期论文

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90.Cai-Hua Chen, Jing Pan, Yu-Qin Di, Wen Liu, Li Hou, Jin-Xing Wang, and Xiao-Fan Zhao*. 2017, Protein kinase C delta phosphorylates ecdysone receptor B1 to promote gene expression and apoptosis under 20-hydroxyecdysone regulation.Proc Natl Acad Sci U S A., Aug 22;114(34):E7121-E7130. doi: 10.1073/pnas.1704999114. Epub 2017 Aug 8. 89. Di Wang, Xiang-Ru Li, Du-Juan Dong, Hua Huang, Jin-Xing Wang, Xiao-Fan Zhao*. 2016, Oct 7. The steroid hormone 20-hydroxyecdysone promotes the cytoplasmic localization of Yorkie to suppress cell proliferation and induce apoptosis. The journal of Biological Chemistry. 291(41):21761-21770. 88. Yong-Bo Li, Xiang-Ru Li, Ting Yang, Jin-Xing Wang, Xiao-Fan Zhao*. 2016, Oct. 21. The steroid hormone 20-hydroxyecdysone promotes switching from autophagy to apoptosis by increasing intracellular calcium levels. Insect Biochemistry and Molecular Biology 79 :73-86. 87. Wen-Li Zhao, Di Wang, Chun-Yan Liu & Xiao-Fan Zhao*. 2016, Jul 14. G-protein-coupled receptor kinase2 terminates G-protein-coupled receptor function in steroid hormone 20-hydroxyecdysone signaling. Scientific Reports,| 6:29205. 86. Di Wang, Xu-Yang Pei, Wen-Li Zhao, Xiao-Fan Zhao*. 2016, May 7. Steroid hormone 20-hydroxyecdysone promotes higher calciummobilization to induce apoptosis. Cell Calcium, 60:1-12. 85. Yu-Pu Jing, Di Wang, Xiao-Lin Han, Du-Juan Dong, Jin-Xing Wang, and Xiao-Fan Zhao*. 2016, June 10. The steroid hormone 20-hydroxyecdysone enhances gene transcription through the cAMP response element-binding protein (CREB) signaling pathway. The journal of Biological Chemistry. 291: 12771–12785. 84. Cai MJ, Zhao WL, Jing YP, Song Q, Zhang XQ, Wang JX, Zhao XF*. 2016, 20-hydroxyecdysone activates Forkhead box O to promote proteolysis during Helicoverpa armigera molting. Development. Feb 18. 143: 1005-1015. doi:10.1242/dev.128694. 83. Chun-Yan Liu, Wen-Li Zhao, Jin-Xing Wang &Xiao-Fan Zhao*. 2015, Cyclin-dependent kinase regulatory subunit 1 promotes cell proliferation by insulin regulation. Cell Cycle, 14:19, 3045—3057. 82.Zhang XQ, Li XR, Ren J, Li YB1, Cai MJ, Wang JX, Zhao XF*. 2015, β-Arrestin1 interacts with G protein-coupled receptor to desensitize signaling ofthe steroid hormone 20-hydroxyecdysone in the lepidopteran insect Helicoverpa armigera. Cell Signal. Apr; 27(4):878-86. doi: 10.1016/j.cellsig.2015.01.016. Epub Feb 4. 81.Wang D, Zhao WL, Cai MJ, Wang JX, Zhao XF*. 2015, G-protein-coupled receptor controls steroid hormone signaling in cell membrane. Sci Rep. Mar 2;5:8675. doi: 10.1038/srep08675. 80. Dong DJ, Jing YP, Liu W, Wang JX, Zhao XF*. 2015, The steroid hormone 20-hydroxyecdysone up-regulates Ste-20 family serine/threonine kinase Hippo to induce programmed cell death. J Biol Chem. Oct 9; 290(41):24738-46. doi: 10.1074/jbc.M115.643783. Epub 2015 Aug 13. 79. Lu Li, Liping Shen, Xiaoqian Zhang, Lingling Shui, Benhui Sui, Xiaoli Zhang,Xiaofan Zhao*, Wenrui Jin*, 2015 Multiplexed optical coding nanobeads and their application in single-molecule counting analysis for multiple gene expression analysis. Anal Chim Acta 886, 123-132; published online EpubJul 30 (10.1016/j.aca.2015.05.042). 78. Yu-Pu Jing, Wen Liu, Jin-Xing Wang, andXiao-Fan Zhao* 2015, The steroid hormone 20-hydroxyecdysone via nongenomic pathway activates Ca2+/calmodulin-dependent protein kinase II to regulate gene expression. J Biol Chem 290, 8469-8481. 77. Cai Mei-Juan, Li Xiang-Rr, Pei Xu-Yang, Liu Wen, Wang Jing-Xing andZhao Xiao-Fan*. 2014, Heat shock protein 90 maintains the stability and function of transcription factor Broad Z7 by interacting with its Broad-Complex-Tramtrack-Bric-a-brac domain. Insect Molecular Biology, July, 23(6), 720–732. 76. Cai Mei-Juan, Liu Wen, Pei Xu-Yang, Li Xiang-Ru, He Hong-Juan, Wang Jin-Xing, andZhao Xiao-Fan*. 2014, Juvenile hormone prevents 20-hydroxyecdysone-induced metamorphosis by regulating the phosphorylation of a newly identified Broad Protein. The journal of Biological Chemistry. Sep 19; 289(38):26630–26641. 75. Ren Jing, Li Xiang-Ru, Liu Peng-Cheng, Cai Mei-Juan, Liu Wen, Wang Jin-Xing,Zhao Xiao-Fan*, 2014, G-protein aq participates in the steroid hormone 20-hydroxyecdysone nongenomic signal transduction. Journal of Steroid Biochemistry & Molecular Biology. Aug 12; 144:313–323.