李相芝 - 山东大学 - 生命科学学院

个人简介

教育背景博士 2003.4-2007.3 日本千叶（Chiba）大学免疫学硕士 2000.4-2002.3 日本熊本（Kumamoto）大学分子生物学本科 1992.9-1997.6 中国农业大学动物医学工作经历 2018.4-现在山东大学生命科学学院教授 2011.8-2018.4 山东大学医学院教授 2007.4-2011.8 美国Michigan大学医学院博士后 2002.10-2007.3 日本理化学研究所(RIKEN) JRA(Junior Research Associates) 1999.4-2002.3 日本国立水俣病研究中心(RCAI）特别研究员

研究领域

1. 干细胞分化的表观遗传学调控2. 肿瘤发生发展的表观遗传学调控 3. 哺乳动物胚胎发育的分子机制

近期论文

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1. Yang Y, Guan J, Shaikh A, Liang Y, Sun L, Wang M, Li D, Qiu C, Li X *. Histone Acetyltransferase Mof Affects the Progression of DSS-Induced Colitis. Cell Physiol Biochem. 2018; 47: xx-xx. （IF= 5.104） 2. Liang Y, Yang Y, Guo R, Gao S, Guo X, Li D, Wang M, Koseki H, Li X*. PCL2 regulates p53 stability and functions as a tumor suppressor in breast cancer. Sci Bull. 2018; 63: 629–639.（IF= 4.0） 3. Xu XF, Jing X, Ma HX, Yuan RR, Dong Q, Dong JL, Han XF, Chen ZY, Li XZ *, Wang Y *. miR-181a Participates in Contextual Fear Memory Formation Via Activating mTOR Signaling Pathway. Cereb Cortex. 2017 Aug 22. [Epub ahead of print] （IF= 6.559） 4. Zhao WB, Wang M, Gao S, Shaikh AS, Chen J, Li XZ *. The histone acetyltranseferase KAT8 regulates cell differentiation by suppression of MN1 in AML. Br J Haematol. 2017 May 17. [Epub ahead of print]（IF= 5.67） 5. Yang Y, Han X, He J, Guo X, Shaikh A, Sun L, Gao S, Liang Y, Wang M, Li X *. The histone acetyltransferase MOF is required for the cellular stress response. Sci Bull. 2017; 62: 1559–1561.（IF=4.0） 6. Hong J*, Chen Y, Wang M, Ye L, Qi C, Yuan H, Zheng T, Li X *. Intensification of municipal solid waste disposal in China. Renew Sust Energ Rev. 2017; 69：168-176. （IF=8.05） 7. Xu C, Hong J*, Chen J, Han X, Lin C, Li X*. Is biomass energy really clean? An environmental life-cycle perspective on biomass-based electricity generation in China. J Clean Prod. 2016; 133 (1): 767-776. (IF=5.715) 8. Li X*, Yang Y, Xu X, Xu C, Hong J *. Air pollution from polycyclic aromatic hydrocarbons generated by human activities and their health effects in China. J Clean Prod. 2016; 112: 1360-1367. （IF=5.715） 9. Yang Y, Han X, Guan J, Li X*. Regulation and function of histone acetyltransferase MOF. Front Med. 2014; 8(1):79-83. （IF=1.89） 10. Hong J*, Zhang Y, Xu X, Li X*. Life-cycle assessment of corn-based and cassava-based ethylene production. Biomass Bioenerg. 2014; 67: 304-311. (IF=4.186) 11. Li X, Li L, Byun J, Pandey R, Kuick R, Gardner K, Qin Z, Dou Y. The histone acetyltransferase Mof is a key regulator of the embryonic stem cell core transcription network. Cell Stem Cell. 2012; 11(2)：163-178. (Highlighted paper; Previewed by Cell Stem Cell) （IF=23.394） 12. Li X, Isono K, Yamada D, Endo TA, Endoh M, Shinga J, Mizutani-Koseki Y, Otte AP, Casanova M, Kitamura H, Kamijo T, Sharif J, Ohara O, Toyada T, Bernstein BE, Brockdorff N, Koseki H. Mammalian polycomb-like Pcl2/Mtf2 is a novel regulatory component of PRC2 that can differentially modulate polycomb activity both at the Hox gene cluster and at Cdkn2a genes. Mol Cell Biol. 2011; 31(2):351-364. （IF=4.78） 13. Li X, Corsa CA, Pan PW, Wu L, Ferguson D, Yu X, Min J, Dou Y. MOF and H4 K16 acetylation play important roles in DNA damage repair by modulating recruitment of DNA damage repair protein Mdc1. Mol Cell Biol. 2010; 30(22): 5335-5347. （IF=4.78） 14. Li X, Dou Y. New perspectives for the regulation of acetyltransferase MOF. Epigenetics. 2010; 5(3)：185-188. （IF=4.882） 15. Li X, Wu L, Corsa CA, Kunkel S, Dou Y. Two mammalian MOF complexes regulate transcription activation by distinct mechanisms. Mol Cell. 2009; 36(2): 290-301. (Highlighted paper; Previewed by Molecular Cell). （IF=14.714）